Jeffrey Epp
Dow AgroSciences
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Publication
Featured researches published by Jeffrey Epp.
Bioorganic & Medicinal Chemistry | 2016
Jeffrey Epp; Anita Lenora Alexander; Terry William Balko; Ann M. Buysse; William Kirkland Brewster; Kristy Bryan; John F. Daeuble; Stephen Craig Fields; Roger E. Gast; Renard Antonio Green; Nicholas Martin Irvine; William C. Lo; Christian T. Lowe; James M. Renga; John Sanders Richburg; James Ruiz; Norbert M. Satchivi; Paul R. Schmitzer; Thomas L. Siddall; Jeffery Webster; Monte R. Weimer; Gregory T. Whiteker; Carla N. Yerkes
Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex™ active (2005) and Rinskor™ active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops.
Pest Management Science | 2018
Jeffrey Epp; Paul R. Schmitzer; Gary D. Crouse
Fifty years separate the commercialization of the herbicides trifluralin and halauxifen-methyl. Despite the vast degree of technological change that occurred over that time frame, some aspects of their discovery stories are remarkably similar. For example, both herbicides were prepared very early in the iterative discovery process and both were developed from known lead compound structures by hypothesis-driven research efforts without the use of in vitro assays or computer-aided molecular design. However, there are aspects of the halauxifen-methyl and trifluralin discovery stories that are substantially different. For example, the chemical technology required for the cost-effective production of halauxifen-methyl simply did not exist just two decades prior to its commercial launch. By contrast, the chemical technology required for the cost-effective production of trifluralin was reported in the chemical literature more than two decades prior to its commercial launch. In addition, changes in regulatory environment since the early 1960s ensured that their respective discovery to commercial launch stories would also differ in substantial ways. Ultimately, the time and cost required to develop and register halauxifen-methyl demanded a global initial business case while the lower registration hurdles that trifluralin cleared enabled a narrow initial business case mainly focused on the USA.
Archive | 2002
Terry William Balko; Ann M. Buysse; Jeffrey Epp; Stephen Craig Fields; Christian T. Lowe; Renee Joan Keese; John Sanders Richburg; James Ruiz; Monte R. Weimer; Renard Antonio Green; Roger E. Gast; Kristy Bryan; Nicholas Martin Irvine; William C. Lo; William Kirkland Brewster; Jeffrey Dale Webster
Archive | 2007
Jeffrey Epp; Paul R. Schmitzer; James Ruiz; Terry William Balko; Thomas L. Siddall; Carla N. Yerkes
Archive | 2008
Jeffrey Epp; Paul R. Schmitzer; Terry William Balko; James Ruiz; Carla N. Yerkes; Thomas L. Siddall; William C. Lo
Archive | 2012
Carla N. Yerkes; Christian T. Lowe; Joseph D. Eckelbarger; Jeffrey Epp; Katherine A. Guenthenspberger; Thomas L. Siddall; Paul R. Schmitzer
Archive | 2008
Jeffrey Epp; Paul R. Schmitzer; Katherine A. Guenthenspberger; William C. Lo; Thomas L. Siddall
Archive | 2009
Zoltan Benko; Kristy Bryan; George Davis; Jeffrey Epp; Beth Lorsbach; Kevin G. Meyer; W. Owen; Michael Sullenberger; Jeffery Webster; David Young; Chenglin Yao
Archive | 2008
Jeffrey Epp; William C. Lo; Paul R. Schmitzer; Carla N. Yerkes
Archive | 2014
Joseph D. Eckelbarger; Jeffrey Epp; Lindsey G. Fischer; Christian T. Lowe; Jeff Petkus; Joshua Roth; Norbert M. Satchivi; Paul R. Schmitzer; Thomas L. Siddall