Jeffrey P. Northrop
Stanford University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Jeffrey P. Northrop.
Endocrinology | 1997
Hong Xing; Jeffrey P. Northrop; J. Russell Grove; Katherine E. Kilpatrick; Jui-Lan Su; Gordon M. Ringold
Tumor necrosis factor α (TNFα) is a polypeptide hormone with pleiotropic effects on cellular proliferation and differentiation. To investigate how TNFα inhibits and reverses adipocyte differentiation, we studied the expression of two factors involved in the adipocyte differentiation process. Peroxisome proliferator-activated receptor γ (PPARγ) is a positive regulator of adipogenesis, whereas preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. The expression patterns of both PPARγ and Pref-1 change during early stages of adipocyte differentiation. Decreased expression of Pref-1 and increased expression of PPARγ occur 1 day and 2 days, respectively, after 3T3-L1 cells reach confluence. During TNFα-mediated inhibition of adipocyte differentiation, PPARγ messenger RNA (mRNA) expression stays at low levels. In contrast, TNFα treatment has no effect on the normal decrease in Pref-1 gene expression that occurs during adipogenesis. We observed that certain cytokine and growth factors[ such as TNFα,...
Advances in Experimental Medicine and Biology | 1994
Steffan N. Ho; Luika A. Timmerman; Jeffrey P. Northrop; Gerald R. Crabtree
Present evidence indicates a pathway of signal transmission in T cells that is outlined in figure 1. The elevation in intracellular calcium that is induced by interactions at the antigen receptor leads to the activation of the calcium-dependent phosphatase calcineurin. This in turn leads to the nuclear association of the cytosolic component of NF-ATc. The activation of calcineurin and the nuclear import of NF-ATc can both be blocked by cyclosporin A or FK506 in complex with their respective immunophilins. Once in the nucleus, NF-ATc interacts with NF-ATn to form an active transcriptional complex. NF-ATn is a ubiquitous protein, can be synthesized in response to PMA, and has many similarities to AP-1. The mechanism by which NF-ATc enters the nucleus is unknown, and although it appears to require calcineurin, NF-ATc has not yet been shown to be an in vivo substrate of calcineurin. Alternative mechanisms include the possibility that NF-ATc operates on some cytoplasmic anchor or that other proteins that are controlled by calcineurin carry out the nuclear import of NF-ATc. Although NF-ATp copurifies with NF-ATc, there is as yet no understanding of how NF-ATp is functioning in vivo. Now that these proteins are purified and cloned, the major goals will be to understand their role and the roles of other family members in thymic development.
Clinical Immunology and Immunopathology | 1996
Steffan N. Ho; Neil A. Clipstone; Luika Timmermann; Jeffrey P. Northrop; Isabella A. Graef; David Fiorentino; Jamie Nourse; Gerald R. Crabtree
Nature | 1994
Jeffrey P. Northrop; Steffan N. Ho; Lei Chen; Daryl J. Thomas; Luika A. Timmerman; Garry P. Nolan; Arie Admon; Gerald R. Crabtree
Nature | 1996
Luika A. Timmerman; Neil A. Clipstone; Steffan N. Ho; Jeffrey P. Northrop; Gerald R. Crabtree
Annual Review of Immunology | 1990
Katharine S. Ullman; Jeffrey P. Northrop; Cornelis L. Verweij; Gerald R. Crabtree
Journal of Biological Chemistry | 1993
Jeffrey P. Northrop; Katharine S. Ullman; Gerald R. Crabtree
Genes & Development | 1990
Steven Fiering; Jeffrey P. Northrop; Garry P. Nolan; Petri S. Mattila; Gerald R. Crabtree; Leonard A. Herzenberg
Molecular Endocrinology | 1987
Mark Danielsen; Jeffrey P. Northrop; Jacqueline Jonklaas; Gordon M. Ringold
Journal of Experimental Medicine | 1992
Jeffrey P. Northrop; Gerald R. Crabtree; Petri S. Mattila