Jeffrey S. Mandel

Results of a model AIDS prevention program for high school students in the Philippines

The objectives were to describe the sexual practices of high school students; to describe the process of development of a school-based AIDS prevention program; and to evaluate the effect of this program on students AIDS-related knowledge attitudes and AIDS-preventive behaviors by means of self-administered questionnaires. A cluster-randomized controlled trial with pretest/post-test evaluation was conducted in 4 demographically similar public high schools in a semi-urban district of Metro Manila the Philippines. Of 845 high school students who participated in the baseline survey 804 (95%) completed a postintervention questionnaire. An AIDS prevention program was developed by public high school teachers together with local AIDS experts social scientists and health educators to provide students with accurate information about AIDS dispel misconceptions about casual contagion to foster positive attitudes towards people with AIDS and to develop skills aimed at assessing intended behavior. At baseline 80 (11%) of 804 students reported ever having had sexual intercourse (mean age 14 years). 66 were male and 14 were female (p < 0.001). Among these condom use was low (24%). Reasons for failure to use condoms were: use of other method (26%) and loss of sensitivity (25%). After implementation of the AIDS prevention program the intervention group was more likely to answer correctly that HIV cannot be transmitted by mosquito bites (p < 0.01) through a cough or sneeze (p < 0.01) or by shaking hands with an infected person (p < 0.01). Students who had attended the AIDS education program were less likely to avoid people with AIDS and were more compassionate toward them (p = 0.01). Changes in knowledge about modes of HIV transmission were associated with improvements in preventive knowledge (p < 0.001). While there was no statistically significant overall effect on intended preventive behavior the program appeared to delay the students intended onset of sexual activity. The program was successful in increasing AIDS-related knowledge and improving attitudes toward people with AIDS.

Emerging HIV-1 epidemic in China in men who have sex with men

China is currently undergoing a serious HIV-1 epidemic in intravenous drug users, sex workers, and former plasma donors. Little is known, however, about HIV-1 risk in Chinese men who have sex with men. In this study of seroprevalence in such men in Beijing, we recorded 15 (3.1%, 95% CI 1.8-5.1) of 481 men infected with HIV-1. Overall, 238 (49%) of participants reported unprotected anal intercourse during the previous 6 months. HIV-1 seropositivity was independently associated with being older than 39 years and having had more than 20 male sexual partners. Most men older than 39 years had been married. Our findings suggest the potential for spread of HIV-1 between men who have sex with men and to their heterosexual partners.

Risk of prevalent HIV infection associated with incarceration among injecting drug users in Bangkok, Thailand: case-control study

Abstract Objectives: To identify risks for HIV infection related to incarceration among injecting drug users in Bangkok, Thailand. Design: Case-control study of sexual and parenteral exposures occurring before, during, and after the most recent incarceration. Setting: Metropolitan Bangkok. Participants: Non-prison based injecting drug users formerly incarcerated for at least six months in the previous five years, with documented HIV serostatus since their most recent release; 175 HIV positive cases and 172 HIV negative controls from methadone clinics. Main outcome measure: Injection of heroin and methamphetamine, sharing of needles, sexual behaviour, and tattooing before, during, and after incarceration. Results: In the month before incarceration cases were more likely than controls to have injected methamphetamine and to have borrowed needles. More cases than controls reported using drugs (60% v 45%; P=0.005) and sharing needles (50% v 31%; P<0.01) in the holding cell before incarceration. Independent risk factors for prevalent HIV infection included injection of methamphetamine before detention (adjusted odds ratio 3.3, 95% confidence interval 1.01 to 10.7), sharing needles in the holding cell (1.9, 1.2 to 3.0), being tattooed while in prison (2.1, 1.3 to 3.4), and borrowing needles after release (2.5, 1.3 to 4.4). Conclusions: Injecting drug users in Bangkok are at significantly increased risk of HIV infection through sharing needles with multiple partners while in holding cells before incarceration. The time spent in holding cells is an important opportunity to provide risk reduction counselling and intervention to reduce the incidence of HIV. What is already known on this topic The incidence of HIV in Thailand is highest among injecting drug users in Bangkok Incarceration is a risk factor for incident HIV infection among Thai injecting drug users What this study adds Injecting drug users are at increased risk of HIV infection from sharing needles with multiple partners while in police holding cells before incarceration Other risk factors include injecting methamphetamine before imprisonment, being tattooed while imprisoned, and sharing needles after release

Potential Bridges for HIV Infection to Men Who Have Sex With Men in Guangzhou, China

To assess the potential for HIV acquisition among men who have sex with men (MSM) in Guangzhou, China, we conducted a cross-sectional, anonymous, face-to-face survey of MSM in the metropolitan area of Guangzhou, China. As a pilot recruitment for a cohort study, participants were recruited by convenience sampling through newspaper and television advertising, website information, and respondent referral. Blood samples were tested for HIV, hepatitis B (HBV), hepatitis C (HCV), and syphilis. Client-centered HIV and STD counseling was provided.A total of 201 MSM were interviewed and 200 blood samples were tested. The prevalence of HIV antibody was 0% (97.5% CI 0–1.8%); 17.5% of MSM were HBV surface antigen positive; 1.0% had HCV antibodies; 10.5% had antibodies to syphilis. Syphilis seropositivity was associated with sex with a foreign MSM in the last six months and 10.4% reported sex with a foreign MSM overall. The majority (54.7%) reported unprotected anal sex with other men. Nearly one-third (31.8%) had regular female partners; 25.9% were currently married to a woman; 6% had casual female partners; 4.5% had sex with a female sex worker; 4.5% had sex with a male sex worker; and 12.9% had unprotected vaginal sex and unprotected anal sex with a man in the past six months. Only one MSM reported injection drug use (0.5%). The currently low prevalence of HIV but high level of unprotected anal sex, high prevalence of syphilis infection, and sexual networks that include foreign MSM point to a transient window for HIV prevention among MSM in Guangzhou. We recognize challenges to recruiting a representative sample of MSM and retaining them in longitudinal cohort studies.

A Qualitative Study of Stigma and Discrimination against People Living with HIV in Ho Chi Minh City, Vietnam

Stigma and discrimination against people living with HIV/AIDS (PLHIV) are a pressing problem in Vietnam, in particular because of propaganda associating HIV with the “social evils” of sex work and drug use. There is little understanding of the causes and sequelae of stigma and discrimination against PLHIV in Vietnam. Fifty-three PLHIV participated in focus group discussions in Ho Chi Minh City. Nearly all participants experienced some form of stigma and discrimination. Causes included exaggerated fears of HIV infection, misperceptions about HIV transmission, and negative representations of PLHIV in the media. Participants faced problems getting a job, perceived unfair treatment in the workplace and experienced discrimination in the healthcare setting. Both discrimination and support were reported in the family environment. There is a need to enforce laws against discrimination and provide education to decrease stigma against PLHIV in Vietnam. Recent public campaigns encouraging compassion toward PLHIV and less discrimination from healthcare providers who work with PLHIV have been encouraging.

The Potential for Rapid Sexual Transmission of HIV in China: Sexually Transmitted Diseases and Condom Failure Highly Prevalent Among Female Sex Workers

Commercial sex is believed to play a role in the steadily increasing heterosexual transmission of HIV in China, but little attention has been paid to female sex workers working in the entertainment industry. From October to December 2000, we conducted a cross-sectional survey of 482 women in Baise City, Guangxi Autonomous Region, bordering Yunnan Province. Although no participants had antibodies to HIV infection, 4% of study participants tested positive for markers for syphilis and 21% reported being diagnosed with sexually transmitted diseases in the past year. Women reported low rates of consistent condom use with customers (17%), a spouse or fiancé (9%), and casual partners (13%). A substantial proportion experienced condom failure (20% slippage and 13% breakage). Multivariate analyses found that consistent condom use with customers was related to multiple sexual partnerships, higher condom knowledge, and higher condom-use negotiation skills. Multiple sexual partnerships and higher condom-use negotiation skills predicted consistent condom use with casual partners, whereas higher condom-use negotiation skills did so for consistent condom use with a spouse or fiancé. Our data suggest the need for condom education, condom skills training, and the distribution of reliable condoms among female sex workers. HIV prevention efforts must target these women as well as their clients and sex partners to prevent the further spread of HIV to the general population in China.

Internalized homonegativity/homophobia is associated with HIV-risk behaviours among Ugandan gay and bisexual men

Summary We investigated the relationship of internalized homonegativity/homophobia (IH) to sexual risk behaviours among 216 Ugandan gay and bisexual men, using the 7-item IH scale previously developed on this population. IH was significantly associated with unprotected anal intercourse, and more so with unprotected receptive anal intercourse. Higher IH was also associated with more sex while intoxicated. There was a strong association between anal intercourse of any type and IH, suggesting a complex relationship between anal sex and identification with, or internalization of, homonegativity/homophobia. Specifically, it may be the anal component of sex rather than the sex with another man that is seen as labeling one as homosexual or stigmatizing. Those men who stated that they engaged in sex with other men for love, rather than for the physical feeling or for money, had higher IH scores. These data suggest that there may be an interactive relationship between IH and sexual behaviour, with greater internalization being associated with more stereotypically gay activities, which in turn may lead to more self-identification as gay and thus greater susceptibility to internalization.

High HIV Risk but Inadequate Prevention Services for Men in China Who Have Sex with Men: An Ethnographic Study

China is facing an emerging HIV epidemic among men who have sex with men (MSM). However, the HIV risk and prevention needs of these men are not well understood. We conducted in-depth qualitative interviews between August and October 2000 with 38 persons who identified as being MSM or knowledgeable about the MSM population in Beijing. Our ethnographic study identified 20 different segments of the population of MSM in Beijing and 14 distinct types of venues where these men congregate. Despite high levels of sexual risk taking, few men perceived themselves to be at risk for HIV. The main reasons cited for engaging in unsafe sex were economic survival, misconceptions about HIV, inaccurate assessment of a partners risk, trusting a partner or needing to prove a partner trustworthy, meeting an attractive partner, and cruising in public sex environments. The HIV prevention services currently available in Beijing include mass media education, hotline information and counseling services, venue-based outreach, hospital-based services, and Internet sites, but few of these programs specifically targeted the MSM population. The major barriers to utilizing exiting services were lack of perceived risk, lack of privacy and anonymity, uninteresting program content, and distrust and questionable credibility of providers. Programs need to address issues broader than AIDS, be peer-designed and peer-led, be entertaining, and receive more government support. Our data suggest that many MSM are at high risk for HIV, but receive inadequate services. More effective and sustainable programs must be developed and implemented to prevent the further spread of HIV in this population.

Integrating HIV Prevention Education into Existing Family Planning Services: Results of a Controlled Trial of a Community-Level Intervention for Young Adults in Rural China

Young adults in China are at increasing risk for HIV infection, yet there have been few prevention programs to address this growing public health problem. In 1996–1997, we conducted a community-based AIDS prevention intervention in semirural Kunshan county near Shanghai, which was integrated into an existing family planning network. We recruited 748 study participants aged 18–30 years from two townships similar in their socioeconomic characteristics. The experimental township received a multifaceted 12-month intervention that included written materials, videos, radio programs, small group discussions, home visits, individual counseling, and a free supply of condoms. Data from both townships were collected at baseline and at 12-month follow-up. Among intervention participants, AIDS-related knowledge and attitudes improved significantly. Intervention participants also reported an increase in condom use during the last episode of sexual intercourse from 9% at baseline to 14% at follow-up, while those using condoms as their main contraceptive method increased from 4% to 10% (both p < .05); no such increases occurred among control subjects. This study demonstrates the feasibility of integrating an HIV prevention intervention into an existing family planning services network. Integrating services in this manner may be an approach to a sustainable AIDS intervention in similar settings where reproductive health services are already established.

Community, Family, and Partner-Related Stigma Experienced by Pregnant and Postpartum Women with HIV in Ho Chi Minh City, Vietnam

Pregnant and postpartum women with HIV often face stigma and discrimination at home and in the community. In Vietnam, associations between HIV and the “social evils” of drug use and sex work contribute to stigmatization of people with HIV. We conducted a qualitative study to explore discrimination experienced by HIV-positive pregnant and postpartum women in Ho Chi Minh City at home and in the community. We conducted 20 in-depth interviews and two focus group discussions. Participants described managing disclosure of their HIV infection because of fear of stigma and discrimination, particularly to the wider community. In cases where their HIV status was disclosed, women experienced both discrimination and support. The findings highlight the need for targeted interventions to support pregnant and postpartum women with HIV, particularly during this period when they are connected to the healthcare system and more readily available for counseling.