Jeffrey T. Wei

Reported use of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors was not associated with reduced recurrence of colorectal adenomas

We did a secondary analysis of data from three large colorectal adenoma chemoprevention trials to assess the association between 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor use and reduced risk of recurrent colorectal adenomas. Reported use of HMG-CoA reductase inhibitors was not associated with a reduced recurrence of colorectal adenomas, multiple adenomas, or advanced adenomas. Lack of statistical power from limited exposure to HMG-CoA reductase inhibitors might be responsible for the lack of association.

Quality of colon carcinoma pathology reporting: a process of care study.

In 1996, the Association of Directors of Anatomic and Surgical Pathology (ADASP) published recommendations for colon carcinoma reporting. Since this publication, no study has evaluated physician practice in relation to these recommendations. The objectives of the current study were to describe pathology reporting for colon carcinoma, evaluate potential variations in reporting, and identify areas for improvement.

Endoscopic ablation therapies for Barrett's esophagus: a meta-analysis of stricture complications

Endoscopic ablation therapies for Barretts esophagus: a meta-analysis of stricture complications

HMG-CoA reductase inhibitor use and recurrence of colorectal adenomas

Any Adseoma 0.70 (0.28, 1.75) 1,07 (0,74, 1.04 (0.86, 1.27) 1,03 (0.87, 1.55) 1.23) Any Advanced 2.15(0.55,8.40) 0.98 (0.38, 1.15 (0.63, 2.10) 1.13(0,70, Ad jo in , 2,54) 1,81) 125 (0.66, 1,25 (0.95, hltiple/~lseo. 0.64(0.10, 3.96) 1.31 (1.00, 1,90) ms 2,37) 1.65) 1Adjusted for age, sex, center, lime to followup exam, lifetime number of adenomas, treatment assignment, and BMI; zPPS=polyp prevenlion study

Eating frequency and colon cancer risk

Increased exposure of the colon to bile acids, as a result of increased eating frequency, might promote the development of colon cancer. Our aim was to evaluate the association between eating frequency and colon cancer. We used data from a population-based case-control study of colon cancer in North Carolina. Eating frequency (a combination of meals and snacks) was categorized as fewer than three, three or four, or more than four eating episodes per day. Multivariate logistic regression was used to calculate odds ratios (ORs) for the association between eating frequency and colon cancer, adjusting for confounders. We also performed stratified analyses to evaluate for differences by sex, coffee intake, or tumor site. Six hundred thirty-six participants with colon cancer and 1,048 control participants were included. The effect of eating frequency on colon cancer differed by sex. Among men, participants in the lowest group of eating frequency had approximately half the risk of colon cancer compared with the middle group (adjusted OR = 0.53; 95% confidence interval, CI = 0.30-0.92). Compared with the middle group, men in the highest group had no greater risk of cancer (adjusted OR = 1.03; 95% CI = 0.74-1.44). No significant associations were detected among women. Decreased eating frequency was associated with a lower risk of colon cancer among men but not women.