Jelena M. Vujić

Biological activity and chemical profile of Lavatera thuringiaca L. extracts obtained by different extraction approaches

BACKGROUND Lavatera thuringiaca L. is herbaceous perennial plant from Malvaceae family, which is known for its biological activity and richness in polyphenolic compounds. Despite this, the information regarding the biological activity and chemical profile is still insufficient. PURPOSE Aim of this study was to investigate biological potential and chemical profile of Lavatera thuringiaca L., as well as influence of applied extraction technique on them. STUDY DESIGN AND METHODS Two conventional and four non-conventional extraction techniques were applied in order to obtain extracts rich in bioactive compound. Extracts were further tested for total phenolics, flavonoids, condensed tannins, gallotannins and anthocyanins contents using spectrophotometric assays. Polyphenolic profile was established using HPLC-DAD analysis. Biological activity was investigated regarding antioxidant, cytotoxic and antibacterial activities. Four antioxidant assays were applied as well as three different cell lines for cytotoxic and fifteen bacterial strain for antibacterial activity. RESULTS AND CONCLUSION Results showed that subcritical water extraction (SCW) dominated over the other extraction techniques, where SCW extract exhibited the highest biological activity. Study indicates that plant Lavatera thuringiaca L. may be used as a potential source of biologically compounds.

From Synthesis to Antibacterial Activity of Some New Palladium(II) and Platinum(IV) Complexes

Simultaneously with the rapid development of a wide range of antibacterial agents since the 1940s, bacteria have proved extremely adept at developing resistance to each new employed agent. The rapidly increasing incidence of bacterial resistance to antimicrobial agents has become a serious problem worldwide. Resistance mechanisms have been identified and described for all known antibiotics currently available for clinical use (Fluit et al., 2000).

Stereospecific ligands and their complexes. Part XIV. Crystal structure of the O,O′-dipropyl ester of N,N′-1,2-ethanediylbis- -L-leucine, dihydrochloride

The authors are grateful for the financial support to the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project No. 172016).