Jemma Gilchrist

Fear of cancer recurrence: a theoretical review and novel cognitive processing formulation

PurposeFear of cancer recurrence (FCR) is prevalent among survivors. However, a comprehensive and universally accepted theoretical framework of FCR to guide intervention is lacking. This paper reviews theoretical frameworks previously used to explain FCR and describes the formulation of a novel theoretical framework for FCR.MethodsA systematic review of the literature was undertaken to identify conceptual frameworks or theories applied to FCR. MEDLINE, PubMED, CINAHL, AMED, PsycINFO and Web of Science were searched. Identified conceptual frameworks were reviewed for strength of evidence supporting their validity.ResultsOf 558 papers initially identified, 16 made reference to six different conceptual frameworks relating to FCR. The most comprehensive and evidence-based theoretical approach is the Common Sense Model (CSM). Other approaches have limited evidence supporting their application to FCR. Two theoretical approaches developed in the context of emotional disorders that appear to be highly relevant to FCR: the Self-Regulatory Executive Function (S-REF) model and Relational Frame Theory were combined with the CSM to produce a novel cognitive processing account of FCR.ConclusionsFew conceptual frameworks have been used consistently to guide FCR research, and not all frameworks are empirically well supported, suggesting that further discussion regarding the conceptualisation of FCR is needed. The novel theoretical framework for FCR presented highlights the multidimensional nature of FCR and the importance of cognitive processing and metacognitions in the development and maintenance of FCR.Implications for Cancer SurvivorsThe novel theoretical formulation of FCR outlined here provides a much-needed comprehensive framework to further investigate and address FCR in cancer survivors.

Pilot of a theoretically grounded psychologist-delivered intervention for fear of cancer recurrence (Conquer Fear)

Dear Editor,IntroductionFear of cancer recurrence (FCR), defined as the fear orworry that cancer could return or progress in the sameplace or another part of the body [1], is a commonand debilitating problem among cancer survivors. A re-cent systematic review found that across different cancersites and assessment strategies, the following on aver-age: 73% of cancer survivors report some degree ofFCR (range=39–97%); 49% report moderate to highFCR (range=22–87%); and 7% report high FCR(range=0–15%) [2]. FCR is stable over time and hasbeen shown to impact negatively on quality of life(QOL), psychological adjustment, emotional distressand anxiety, ability to establish future plans and carerQOL [2]. High FCR has also been associated withgreater medical service usage and costs [2]. Despitethe high prevalence, morbidity and potential cost ofFCR, survivors commonly report strong unmet needsfor help managing FCR [2]. This suggests many cancerservices are currently providing inadequate care in thisarea. Indeed, clinicians in psycho-oncology report diffi-culties dealing with high FCR [3]. There is a clear needfor interventions specifically targeting FCR, but veryfew have been developed and evaluated to date [4–6].This paper reports on the pilot testing of a novel, theo-retically based intervention for FCR.MethodsInterventionThe manualised intervention (Conquer Fear) aims to re-duce the impact of FCR and is based on the common-sense model (CSM) of illness [7], self-regulatory execu-tive function (S-REF) model [8] and Relational FrameTheory (RFT) [9]. Key intervention objectives includethe following: (a) teaching strategies for controllingworry and excessive threat monitoring (S-REF), (b)modifying unhelpful beliefs about worry (S-REF), (c)developing appropriate monitoring and screeningbehaviours (CSM), (d) providing information aboutfollow-up care and empirically supported behaviouralchange (e.g. weight loss and exercise) to reduce riskof recurrence (CSM), (e) addressing cancer-related exis-tential changes (RFT), and (f) promoting values-basedgoal-setting (RFT). The intervention comprises five60–90 min, individual face-to-face sessions with atrained psychologist/psychiatrist (therapist). Home-basedpractice and reading (≈2 h/week) is encouraged to con-solidate skills. See Table 1 for an overview of sessioncontent. More details are provided in Butow et al. [10].Study designThe feasibility, acceptability and likely efficacy ofConquer Fear were evaluated in a small longitudinalsingle-arm pilot study approved by relevant local ethicscommittees.

Randomized Trial of ConquerFear: A Novel, Theoretically Based Psychosocial Intervention for Fear of Cancer Recurrence

Purpose Fear of cancer recurrence (FCR) is prevalent, distressing, and long lasting. This study evaluated the impact of a theoretically/empirically based intervention (ConquerFear) on FCR. Methods Eligible survivors had curable breast or colorectal cancer or melanoma, had completed treatment (not including endocrine therapy) 2 months to 5 years previously, were age > 18 years, and had scores above the clinical cutoff on the FCR Inventory (FCRI) severity subscale at screening. Participants were randomly assigned at a one-to-one ratio to either five face-to-face sessions of ConquerFear (attention training, metacognitions, acceptance/mindfulness, screening behavior, and values-based goal setting) or an attention control (Taking-it-Easy relaxation therapy). Participants completed questionnaires at baseline (T0), immediately post-therapy (T1), and 3 (T2) and 6 months (T3) later. The primary outcome was FCRI total score. Results Of 704 potentially eligible survivors from 17 sites and two online databases, 533 were contactable, of whom 222 (42%) consented; 121 were randomly assigned to intervention and 101 to control. Study arms were equivalent at baseline on all measured characteristics. ConquerFear participants had clinically and statistically greater improvements than control participants from T0 to T1 on FCRI total ( P < .001) and severity subscale scores ( P = .001), which were maintained at T2 ( P = .017 and P = .023, respectively) and, for FCRI total only, at T3 ( P = .018), and from T0 to T1 on three FCRI subscales (coping, psychological distress, and triggers) as well as in general anxiety, cancer-specific distress (total), and mental quality of life and metacognitions (total). Differences in FCRI psychological distress and cancer-specific distress (total) remained significantly different at T3. Conclusion This randomized trial demonstrated efficacy of ConquerFear compared with attention control (Taking-it-Easy) in reduction of FCRI total scores immediately post-therapy and 3 and 6 months later and in many secondary outcomes immediately post-therapy. Cancer-specific distress (total) remained more improved at 3- and 6-month follow-up.

A systematic review of women’s satisfaction and regret following risk-reducing mastectomy

OBJECTIVE A systematic review of quantitative and qualitative studies, to describe patient satisfaction and regret associated with risk-reducing mastectomies (RRM), and the patient-reported factors associated with these among women at high risk of developing breast cancer. METHODS Studies were identified using Medline, CINAHL, Embase and PsycInfo databases (1995-2016). Data were extracted and crosschecked for accuracy. Article quality was assessed using standardised criteria. RESULTS Of the 1657 unique articles identified, 30 studies met the inclusion criteria (n=23 quantitative studies, n=3 qualitative studies, n=4 mixed-method studies). Studies included were cross-sectional (n=23) or retrospective (n=7). General satisfaction with RRM, decision satisfaction and aesthetic satisfaction were generally high, although some women expressed regret around their decision and dissatisfaction with their appearance. Factors associated with both patient satisfaction and regret included: post-operative complications, body image changes, psychological distress and perceived inadequacy of information. CONCLUSION While satisfaction with RRM was generally high, some women had regrets and expressed dissatisfaction. Future research is needed to further explore RRM, and to investigate current satisfaction trends given the ongoing improvements to surgical and clinical practice. PRACTICE IMPLICATIONS Offering pre-operative preparation, decisional support and continuous psychological input may help to facilitate satisfaction with this complex procedure.

The development of a template for psychological assessment of women considering risk‐reducing or contralateral prophylactic mastectomy: A national Delphi consensus study

Risk‐reducing mastectomies (RRM) and contralateral prophylactic mastectomies (CPM) are increasingly prevalent strategies to reduce breast cancer risk. Given the associated physical and emotional challenges, presurgical psychological assessment is frequently recommended for this population, yet limited research exists to guide this. This study aimed to reach a consensus on the most relevant content and format of a psychological consultation prior to RRM/CPM.

Pilot of a theoretically grounded psychologist-delivered intervention for fear of cancer recurrence

Dear Editor,IntroductionFear of cancer recurrence (FCR), defined as the fear orworry that cancer could return or progress in the sameplace or another part of the body [1], is a commonand debilitating problem among cancer survivors. A re-cent systematic review found that across different cancersites and assessment strategies, the following on aver-age: 73% of cancer survivors report some degree ofFCR (range=39–97%); 49% report moderate to highFCR (range=22–87%); and 7% report high FCR(range=0–15%) [2]. FCR is stable over time and hasbeen shown to impact negatively on quality of life(QOL), psychological adjustment, emotional distressand anxiety, ability to establish future plans and carerQOL [2]. High FCR has also been associated withgreater medical service usage and costs [2]. Despitethe high prevalence, morbidity and potential cost ofFCR, survivors commonly report strong unmet needsfor help managing FCR [2]. This suggests many cancerservices are currently providing inadequate care in thisarea. Indeed, clinicians in psycho-oncology report diffi-culties dealing with high FCR [3]. There is a clear needfor interventions specifically targeting FCR, but veryfew have been developed and evaluated to date [4–6].This paper reports on the pilot testing of a novel, theo-retically based intervention for FCR.MethodsInterventionThe manualised intervention (Conquer Fear) aims to re-duce the impact of FCR and is based on the common-sense model (CSM) of illness [7], self-regulatory execu-tive function (S-REF) model [8] and Relational FrameTheory (RFT) [9]. Key intervention objectives includethe following: (a) teaching strategies for controllingworry and excessive threat monitoring (S-REF), (b)modifying unhelpful beliefs about worry (S-REF), (c)developing appropriate monitoring and screeningbehaviours (CSM), (d) providing information aboutfollow-up care and empirically supported behaviouralchange (e.g. weight loss and exercise) to reduce riskof recurrence (CSM), (e) addressing cancer-related exis-tential changes (RFT), and (f) promoting values-basedgoal-setting (RFT). The intervention comprises five60–90 min, individual face-to-face sessions with atrained psychologist/psychiatrist (therapist). Home-basedpractice and reading (≈2 h/week) is encouraged to con-solidate skills. See Table 1 for an overview of sessioncontent. More details are provided in Butow et al. [10].Study designThe feasibility, acceptability and likely efficacy ofConquer Fear were evaluated in a small longitudinalsingle-arm pilot study approved by relevant local ethicscommittees.

Pilot of a theoretically grounded psychologist-delivered intervention for fear of cancer recurrence (Conquer Fear): Conquer Fear: a promising new treatment for fear of cancer recurrence

Dear Editor,IntroductionFear of cancer recurrence (FCR), defined as the fear orworry that cancer could return or progress in the sameplace or another part of the body [1], is a commonand debilitating problem among cancer survivors. A re-cent systematic review found that across different cancersites and assessment strategies, the following on aver-age: 73% of cancer survivors report some degree ofFCR (range=39–97%); 49% report moderate to highFCR (range=22–87%); and 7% report high FCR(range=0–15%) [2]. FCR is stable over time and hasbeen shown to impact negatively on quality of life(QOL), psychological adjustment, emotional distressand anxiety, ability to establish future plans and carerQOL [2]. High FCR has also been associated withgreater medical service usage and costs [2]. Despitethe high prevalence, morbidity and potential cost ofFCR, survivors commonly report strong unmet needsfor help managing FCR [2]. This suggests many cancerservices are currently providing inadequate care in thisarea. Indeed, clinicians in psycho-oncology report diffi-culties dealing with high FCR [3]. There is a clear needfor interventions specifically targeting FCR, but veryfew have been developed and evaluated to date [4–6].This paper reports on the pilot testing of a novel, theo-retically based intervention for FCR.MethodsInterventionThe manualised intervention (Conquer Fear) aims to re-duce the impact of FCR and is based on the common-sense model (CSM) of illness [7], self-regulatory execu-tive function (S-REF) model [8] and Relational FrameTheory (RFT) [9]. Key intervention objectives includethe following: (a) teaching strategies for controllingworry and excessive threat monitoring (S-REF), (b)modifying unhelpful beliefs about worry (S-REF), (c)developing appropriate monitoring and screeningbehaviours (CSM), (d) providing information aboutfollow-up care and empirically supported behaviouralchange (e.g. weight loss and exercise) to reduce riskof recurrence (CSM), (e) addressing cancer-related exis-tential changes (RFT), and (f) promoting values-basedgoal-setting (RFT). The intervention comprises five60–90 min, individual face-to-face sessions with atrained psychologist/psychiatrist (therapist). Home-basedpractice and reading (≈2 h/week) is encouraged to con-solidate skills. See Table 1 for an overview of sessioncontent. More details are provided in Butow et al. [10].Study designThe feasibility, acceptability and likely efficacy ofConquer Fear were evaluated in a small longitudinalsingle-arm pilot study approved by relevant local ethicscommittees.