Jenny Hall
University of Nottingham
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Publication
Featured researches published by Jenny Hall.
British Journal of Obstetrics and Gynaecology | 1997
Jason Gardosi; Theo Mul; Andy Francis; Jenny Hall; Simon Fishel
The objective of this study was to investigate the size of singleton vs twin pregnancies at the time of a second trimester dating scan. The analysis included 86 infants from 63 pregnancies achieved with assisted reproductive techniques, comprising 40 singletons and 46 twins. Measurements of second trimester biparietal diameter (n= 85) and femur length (n= 74) were plotted against the precisely known gestational age. A common regression line was calculated for each parameter and the residuals for singletons and twins were compared. Gestational age and weight at birth were also analysed for each group. There was no significant difference between singletons and twins in biparietal diameter or femur length in second trimester. In contrast, twins had a lower mean birthweight, gestational age at birth, and weight‐for‐gestational age centile compared with singletons. Singleton babies from these pregnancies had an average birthweight centile of 49.8% (i.e. close to the median for spontaneously conceived pregnancies in our population). We concluded that the same pregnancy dating charts can be used for singletons and twins. At corresponding gestational age, twins are smaller than singletons at birth because of slower growth in the third trimester.
Human Reproduction | 1995
Steven Green; Simon Fishel; Jenny Hall; Alison Hunter; Steven Fleming; Geoffrey Hobson; Heather Roe; Ken Dowell; Simon Thornton; Lucas D. Klentzeris
Utilizing real-time computer image analysis, individual spermatozoa were selected using microaspiration. Selection criteria were based on potential hyperactivation motility characteristics; the amplitude of lateral head displacement > 7.5 microns, curvilinear velocity > 70 microns/s and linearity of < 30%. For this pilot study, 16 patients (eight in each group) were recruited. Using subzonal insemination (SUZI), up to five (mean = 4.4 +/- 0.3) spermatozoa selected using computer-image sperm selection (CISS) were micro-injected, or up to 15 (mean = 12.8 +/- 1.3 SD) unselected spermatozoa. In the group which utilized CISS, 28 out of 49 (57%) oocytes were fertilized compared with 13 out of 52 (25%) utilizing conventional SUZI (P < 0.04); polyspermy was 20% (n = 10) and 2% (n = 1) respectively. CISS with SUZI showed increased efficiency in achieving fertilization and is a novel approach to studying individual sperm function in a sperm egg bioassay where gamete ratios are close to unity.
Best Practice & Research in Clinical Obstetrics & Gynaecology | 1994
Steven Fleming; Steve Green; Jenny Hall; Simon Fishel
Comprehension of the intricate complexities of sperm function is clearly crucial to the success of attempts to manipulate it for the purposes of assisted conception. This is particularly important when considering various procedures for microassisted fertilization since these bypass critical physiological events that are mandatory for normal fertilization, to varying degrees. Methylxanthine derivatives such as pentoxifylline are useful agents for the management of oligoasthenozoospermic patients. This is particularly so for procedures such as SUZI where adequate motility of spermatozoa injected into the perivitelline space is crucial for fusion with the vitelline membrane to achieve fertilization. The generation of minute concentrations of reactive oxygen species in vitro may prove to be a valuable technique in this respect, in the light of recent evidence for their involvement in capacitation and hyperactivation. Induction of the acrosome reaction by non-invasive, non-toxic agents should markedly improve success rates for microassisted fertilization. Acrosin appears to play a central role in this and, therefore, it would seem prudent to monitor levels of acrosin activity in samples of spermatozoa used in assisted conception procedures. With respect to microassisted fertilization, the potential to select recently acrosome-reacted spermatozoa coated by activated acrosin promises to be a major improvement. Current methods employed for determination of the fertilization potential of spermatozoa are clearly inadequate (Polansky and Lamb, 1988; Aitken, 1990). In fact, the prevailing evidence suggests that no single parameter of sperm function reflects this potential (Zaneveld and Jeyendran, 1988). Therefore, we have both a scientific and a moral responsibility to investigate these processes further. Subsequently, we should be in a position to identify individual gametes with the potential for fertilization and so utilize procedures that result in maximal fertilization rates with minimal risk of polyploidy or abnormality.
Molecular Human Reproduction | 1996
Aldo E. Calogero; Jenny Hall; Simon Fishel; Steven Green; Alison Hunter; Rosario D'Agata
Human Reproduction | 1998
Aldo E. Calogero; Simon Fishel; Jenny Hall; E Ferrara; E Vicari; Steven Green; Alison Hunter; Nunziatina Burrello; S Thornton; Rosario D'Agata
Human Reproduction | 1995
Jenny Hall; Simon Fishel; Steven Green; Steven Fleming; Alison Hunter; Neil R. Stoddart; Ken Dowell; Simon Thornton
Human Reproduction | 1995
Lucas D. Klentzeris; Simon Fishel; H. McDermott; Ken Dowell; Jenny Hall; Steven Green
Molecular Human Reproduction | 2002
Nicole D. Hussey; Tenielle Davis; Jenny Hall; Michael Barry; Rogan Draper; Robert J. Norman; Zbigniew Rudzki
Human Reproduction | 1993
Simon Fishel; Ken Dowell; Judy Timson; Steven Green; Jenny Hall; Lucas D. Klentzeris
Molecular Human Reproduction | 1995
Lucas D. Klentzeris; Simon Fishel; H. McDermott; Ken Dowell; Jenny Hall; Steven Green