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Dive into the research topics where Jenny Rattfelt Nyholm is active.

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Featured researches published by Jenny Rattfelt Nyholm.


Science of The Total Environment | 2013

Environmental occurrence of emerging and legacy brominated flame retardants near suspected sources in Norway

Jenny Rattfelt Nyholm; Roman Grabic; Hans Peter H. Arp; Thomas Moskeland; Patrik L. Andersson

The environmental occurrence of potentially emerging brominated flame retardants (BFRs) was investigated near suspected source zones in Norway, within seepage water, sewage waste water, sewage sludges, and sediments. Analyzed emerging BFRs included 1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), decabromodiphenylethane (DBDPE), ethylene bis(tetrabromophthalimide) (EBTPI), tetrabromobisphenol A diallyl ether (TBBPA AE), and tetrabromobisphenol A bis(2,3-dipropyl ether) (TBBPA DBPE). In addition selected polybrominated diphenylethers (PBDEs) were analyzed, so that findings could be compared to legacy BFRs. An analytical method based on liquid chromatography atmospheric pressure photoionization tandem mass spectrometry was developed for analysis of EBTPI, TBBPA AE, and TBBPA DBPE. The legacy BFRs were in general found in higher levels and abundances than the studied emerging BFRs. However, BTBPE was detected in most of the studied matrices (sewage sludge, seepage water and sediment). DBDPE was detected in sewage sludge, waste water, seepage water and in sediment taken close to a combined metal recycling and car dismantling site. TBECH was found in seepage water, waste water and sewage sludge. EBTPI was identified in one seepage water sample; TBBPA AE was detected both in seepage water and sediment, and TBPPA DBPE in waste water and seepage water. Of the emerging BFRs, the highest levels in water samples were quantified for TBBPA DBPE (81 ng/L, seepage water from a combined metal recycling and car dismantling site) and in sediment for BTBPE (6.5 ng/g, taken close to landfill). The findings of current-use BFRs in seepage water, sediment and in sewage suggest that further investigations are needed of the environmental fate and effects of these flame retardants.


Aquatic Toxicology | 2010

Oral exposure of adult zebrafish (Danio rerio) to 2,4,6-tribromophenol affects reproduction

Anna Norman Haldén; Jenny Rattfelt Nyholm; Patrik L. Andersson; Henrik Holbech; Leif Norrgren

The bromophenol 2,4,6-tribromophenol (TBP) is widely used as an industrial chemical, formed by degradation of tetrabromobisphenol-A, and it occurs naturally in marine organisms. Concentrations of TBP in fish have been related to intake via feed, but little is known about effects on fish health after oral exposure. In this study, we exposed adult male and female zebrafish (Danio rerio) to TBP via feed in nominal concentrations of 33, 330, and 3300 μg/g feed (or control feed) for 6 weeks to assess the effects of TBP on reproductive output, gonad morphology, circulatory vitellogenin levels, and early embryo development. The aim was also to investigate the extent to which TBP was metabolised to 2,4,6-tribromoanisole (TBA) in dietary exposed zebrafish, and the amounts of TBP and TBA found in offspring. After 6 weeks of exposure, we found about 3% of the daily dose of TBP in adult fish and the mean concentration of TBA was 25-30% of the TBP concentration. TBP and TBA were detected in offspring with wet weight-based egg/fish concentration ratios well below one. Exposure to TBP significantly reduced the fertilization success and disturbed the gonad morphology, i.e. fewer spermatid cysts in males and increased presence of atretic follicles and oocytes with decreased vitellogenesis in females. In females, the disturbed gonad morphology was accompanied by increased levels of circulating vitellogenin. Significant effects were observed at 3300 μg/g feed. Offspring early development was not significantly affected, but yolk-sac oedema tended to increase in frequency in exposed groups with time. Our results show that dietary exposure to TBP, at concentrations found in marine organisms that are part of the natural diet of wild fish, can interfere with reproduction in zebrafish. We also observed low accumulation from feed of TBP in zebrafish and biotransformation of TBP to TBA. This is the first paper showing gonadal histopathological changes and effects on fertility in TBP exposed fish.


Environmental Science & Technology | 2010

Accumulation of Polybrominated Diphenyl Ethers, Hexabromobenzene, and 1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane in Earthworm (Eisenia fetida). Effects of Soil Type and Aging

Jenny Rattfelt Nyholm; Robert Kumah Asamoah; Leon van der Wal; Conny Danielsson; Patrik L. Andersson

In the present study the accumulation potentials in earthworms (Eisenia fetida) of selected brominated flame retardants (BFRs) were investigated. The tested BFRs, including polybrominated diphenyl ethers (PBDEs), hexabromobenzene (HBB), and 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (TBECH), were found to be bioavailable to Eisenia fetida, and they accumulated in the earthworms. To our knowledge, this is the first published study to address the bioaccumulation potential of TBECH in terrestrial biota. Aging the soil resulted in decreased accumulation of TBECH, HBB, and PBDEs with six or less bromine atoms. However, no effect of soil aging was seen for BDEs 183 or 209, possibly due to their low mobility in soil. The use of different soils (artificial OECD soil and two natural Swedish soils) also affected the degree of accumulation in the worms. The results indicate that use of the generally accepted standard OECD soil may overestimate accumulation of organic contaminants by earthworms, due to high bioavailability of the contaminants and/or weight loss of the worms in it. Further, the accumulation of selected PBDEs and HBB was compared to the accumulation of their chlorinated analogues. Brominated compounds accumulated to the same or a lesser extent than their chlorinated counterparts.


Chemosphere | 2008

Are individual NOEC levels safe for mixtures? A study on mixture toxicity of brominated flame-retardants in the copepod Nitocra spinipes.

Magnus Breitholtz; Jenny Rattfelt Nyholm; Jenny Karlsson; Patrik L. Andersson

In aquatic ecosystems organisms are exposed to mixtures of pollutants. Still, risk assessment focuses almost exclusively on effect characterization of individual substances. The main objective of the current study was therefore to study mixture toxicity of a common group of industrial substances, i.e., brominated flame-retardants (BFRs), in the harpacticoid copepod Nitocra spinipes. Initially, 10 BFRs with high hydrophobicity but otherwise varying chemical characteristics were selected based on multivariate chemical characterization and tested individually for effects on mortality and development using a partial life cycle test (six days) where silica gel is used as a carrier of the hydrophobic substances. Based on these findings, six of the 10 BFRs were mixed in a series of NOEC proportions (which were set to 0.008, 0.04, 0.2, 1, and five times the NOEC concentrations for each individual BFR), loaded on silica gel and tested in a full life cycle test (26 days). Significantly increased mortality was observed in N. spinipes after six and 26 days exposure at a NOEC proportion that equals the NOEC LDR value (x1) for each BFR in the mixture (p=0.0015 and p=0.0105, respectively). At the NOECx5 proportion all animals were dead. None of the other NOEC proportions caused significant negative responses related to development and reproduction. This shows that low concentrations of individual substances can cause toxicity if exposed in mixtures, which highlights the need to consider mixture toxicity to a greater extent in regulatory work.


Chemosphere | 2008

Maternal transfer of brominated flame retardants in zebrafish (Danio rerio)

Jenny Rattfelt Nyholm; Anna Norman; Leif Norrgren; Peter Haglund; Patrik L. Andersson


Environmental Pollution | 2010

Biodegradation kinetics of selected brominated flame retardants in aerobic and anaerobic soil

Jenny Rattfelt Nyholm; Charlott Lundberg; Patrik L. Andersson


Environmental Toxicology and Chemistry | 2009

Uptake and biotransformation of structurally diverse brominated flame retardants in zebrafish (Danio rerio) after dietary exposure

Jenny Rattfelt Nyholm; Anna Norman; Leif Norrgren; Peter Haglund; Patrik L. Andersson


Journal of Environmental Monitoring | 2011

Presence and partitioning properties of the flame retardants pentabromotoluene, pentabromoethylbenzene and hexabromobenzene near suspected source zones in Norway

Hans Peter H. Arp; Thomas Moskeland; Patrik L. Andersson; Jenny Rattfelt Nyholm


Deep-sea Research Part Ii-topical Studies in Oceanography | 2016

Chemical Munitions Search & Assessment - an evaluation of the dumped munitions problem in the Baltic Sea

Jacek Bełdowski; Zygmunt Klusek; Marta Szubska; Raisa Turja; Anna I. Bulczak; Daniel Rak; Matthias Brenner; Thomas Lang; Lech Kotwicki; Katarzyna Grzelak; Jaromir Jakacki; Nicolai Fricke; Anders Östin; Ulf Olsson; Jacek Fabisiak; Galina Garnaga; Jenny Rattfelt Nyholm; Piotr Majewski; Katja Broeg; Martin Söderström; Paula Vanninen; Stanisław Popiel; Jakub Nawała; Kari K. Lehtonen; Rune Berglind; Beata Schmidt


EPIC3International Symposium for sea-dumped munition and UXO, Schleswig-Holstein's Representation to the German Federal Government, In den Ministergärten 8, 10117 Berlin, 2018-05-03 | 2018

Biological effects of dumped warfare agents on the Baltic mussel Mytilus spp.; first results from field and lab exposure studies

Matthias Brenner; Nicole Höher; Romina Schuster; Raisa Turja; Anu Lastumäki; Jenny Rattfelt Nyholm; Anders Östin; Per Leffler; Laura Butrimavičienė; Mia Halme; Maaret Karjalainen; Hanna Niemikoski; Jennifer S. Strehse; Katja Broeg; Janina Barsiene; Paula Vanninen; Edmund Maser; Ulf Bickmeyer; Kari K. Lehtonen; Rune Berglind

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Kari K. Lehtonen

Finnish Environment Institute

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Raisa Turja

Finnish Environment Institute

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Matthias Brenner

Alfred Wegener Institute for Polar and Marine Research

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Katja Broeg

Alfred Wegener Institute for Polar and Marine Research

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Anders Östin

Swedish Defence Research Agency

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Leif Norrgren

Swedish University of Agricultural Sciences

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