Jens Soentgen

Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations

The pathophysiological pathways linking particulate air pollution to cardiovascular disease are still not fully understood. We examined the association between ambient air pollutants and blood markers of inflammation and coagulation/fibrinolysis in three potentially susceptible populations. Three panels of non-smoking individuals were examined between 3/2007 and 12/2008: 1) with type 2 diabetes mellitus (T2D, n=83), 2) with impaired glucose tolerance (IGT, n=104), and 3) with a potential genetic predisposition which could affect detoxifying and inflammatory pathways (n=87) defined by the null polymorphism for glutathione S-transferase M1 (GSTM1) in combination with a certain single nucleotide polymorphism on the C-reactive protein (CRP) or the fibrinogen gene. Study participants had blood drawn up to seven times every four to six weeks. In total, 1765 blood samples were analysed for CRP, interleukin (IL)-6, soluble CD40 ligand (sCD40L), fibrinogen, myeloperoxidase (MPO), and plasminogen activator inhibitor-1 (PAI-1). Hourly mean values of particulate air pollutants, particle number concentrations in different size ranges and gaseous pollutants were collected at fixed monitoring sites and individual 24hour averages calculated. Associations between air pollutants and blood markers were analysed for each panel separately and taking the T2D panel and the IGT panel together, using additive mixed models adjusted for long-term time trend and meteorology. For the panel with potential genetic susceptibility, CRP and MPO increased for most lags, especially with the 5-day average exposure (% change of geometric mean and 95% confidence interval: 22.9% [12.0;34.7] for CRP and 5.0% [0.3;9.9] for MPO per interquartile range of PM2.5). Small positive associations were seen for fibrinogen while sCD40L, PAI-1 and IL-6 mostly decreased in association with air pollution concentrations. Except for positive associations for fibrinogen we did not see significant results with the two other panels. Participants with potential genetic susceptibility showed a clear association between inflammatory blood biomarkers and ambient air pollutants. Our results support the hypothesis that air pollution increases systemic inflammation especially in susceptible populations which may aggravate atherosclerotic diseases and induce multi-organ damage.

Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations -results from a panel study.

BACKGROUND AND AIMS Epidemiological studies have shown adverse effects of ambient air pollutants on health with inflammation and oxidative stress playing an important role. We examine the association between blood biomarkers of inflammation and coagulation and physical attributes of particulate matter which are not routinely measured such as particle length or surface area concentration and apparent density of PM. METHODS Between 3/2007 and 12/2008 187 non-smoking individuals with type 2 diabetes mellitus (T2D) or impaired glucose tolerance (IGT) were examined within the framework of the KORA Study in Augsburg, Germany. In addition, we selected 87 participants with a potential genetic predisposition on detoxifying and inflammatory pathways. This was defined by the null polymorphism for glutathione S-transferase M1 in combination with a certain single nucleotide polymorphism on the C-reactive protein (CRP) gene (rs1205) or the fibrinogen gene (rs1800790). Participants had blood drawn up to seven different times, resulting in 1765 blood samples. Air pollutants were collected at a central measurement station and individual 24-h averages calculated. Associations between air pollutants and high sensitivity CRP, myeloperoxidase (MPO), interleukin (IL)-6 and fibrinogen were analysed using additive mixed models. RESULTS For the panel with genetic susceptibility, increases were seen for CRP and MPO with most attributes, specifically particle length and active surface concentration. The %change of geometric mean and 95% confidence intervals for the 5-day average exposure for CRP and MPO were 34.6% [21.8;48.8] and 8.3% [3.2;13.6] per interquartile range increase of particle length concentration and 29.8% [15.9;45.3] and 10.4 [4.4;16.7] for active surface area. Results for the panel of T2D and IGT and the other blood biomarkers were less conclusive. CONCLUSIONS Particle length concentration and active surface concentration showed strong positive associations with blood biomarkers reflecting inflammation. These air pollution metrics might reflect harmful aerosol properties better than particulate mass or number concentration. They might therefore be important for epidemiological studies.

Effects of Goal Framing and Emotions on Perceived Threat and Willingness to Sacrifice for Climate Change

This study explores discrete emotions (guilt, fear, hope) as mediators for effects of goal framing on perceived threat of climate change and willingness to sacrifice. To reconcile conflicting evidence, the study introduces and tests the distinction between gain-positive frames (positive consequences of engaging in climate protection), gain-negative frames (avoiding negative consequences when engaging in climate protection), and loss frames (negative consequences of not engaging in climate protection). Results show that gain-negative frames increase perceived threat and willingness to sacrifice, while loss frames increase them through guilt and fear. Hope is increased by a gain-positive frame but subsequently lowers both outcomes.

Die Politisierung des Konsums

Polyvinylchlorid (PVC) läutete in den 1950er Jahren die massenhafte Ankunft von Plastik in Westdeutsch land ein – und gilt als Sinnbild dafür, dass sich die Nachkriegsgesell schaft in hohem Maß auf technische Innova tion verließ, um soziale Ordnung zu etablieren. Ab den 1960er Jahren wurde diese Ordnung erschüt tert: PVC geriet wiederholt als gesundheitsund umweltschädlich in die Kritik. Westermann, A. 2007. Plastik und politische Kultur in Westdeutschland. Reihe Interferenzen – Studien zur Kulturgeschichte der Technik, Band 13. Zürich: Chronos. 392 S., 38,– EUR, 58,– CHF, ISBN 978-3-0340-0849-5 Jens Soentgen BÜCHER