Jerome C. Hurley
United States Department of Agriculture
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Jerome C. Hurley.
Journal of Controlled Release | 2002
Jerome C. Hurley; John J. Johnston
Sixty-three mallards were fed one of ten poly(methyl methacrylate) based synthetic grit formulations containing varying concentrations of a proposed wildlife contraceptive (nicarbazin), plasticizer (acetyl tributylcitrate) and/or cross-linking agent (1,4-butanediol diacrylate). Release characteristics of the contraceptive agent were monitored for the purpose of developing a contraceptive formulation for control of pest waterfowl in urban settings. The addition of plasticizer increased the erosion rate (t(1/2)=0.97-2.85 days), cross-linking the polymer matrix slightly decreased the erosion rate (t(1/2)=4.45-5.05 days) and increasing the concentration of the contraceptive agent increased the erosion rate (t(1/2)=3.3 and 9.9 days at 60% and 7.5% active ingredient, respectively). The larger and smaller grit pieces had longer half lives at 11.0 and 11.6 days, respectively while the mid sized grit had a half life of 4.95 days. Control grit had a half life of 12.7 days based on weight loss. Analysis of blood and feces for monitoring release from the grit and approximate indirect plasma levels of the active ingredient proved feasible.
Journal of Wildlife Diseases | 2012
Tricia L. Fry; Kaci Van Dalen; Jerome C. Hurley; Paul Nash
RABORAL V-RG®a is a recombi-nant vaccine used in oral rabies vaccination (ORV) programs for wildlife in the United States. Vaccination rates for raccoons are substantially lower than vaccination rates for gray foxes and coyotes. Research suggests that the low viscosity of the oral vaccine may preclude animals from receiving an effective dose when biting into the vaccine bait delivery system. We evaluated the possibility of using two benign compounds, chitosan and N,N,N-trimethylated chitosan (TMC), to increase the viscosity of the vaccine and potentially act as adjuvants to improve the immune response in raccoons (Procyon lotor). Forty mildly sedated raccoons were orally vaccinated via needleless syringe with either RABORAL V-RG (n=12), chitosan+RABORAL V-RG (n=12), TMC+ RABORAL V-RG (n=12), or no vaccine (n=4), on day 0 and again on day 90. We collected sera every 2–4 wk for 4 mo and evaluated rabies virus-neutralizing antibodies (rVNA). Raccoons were considered responders if rVNA titers were ≥0.1 IU/mL. Eleven of 12 raccoons vaccinated with TMC+RABORAL V-RG responded after one dose of vaccine, as did eight of 12 vaccinated with RABORAL V-RG, and three of 12 vaccinated with chitosan+ RABORAL V-RG. Our results suggest that the inclusion of an adjuvant, such as TMC, could increase vaccine efficacy to aid in controlling rabies virus spread in wildlife reservoirs.
Journal of Wildlife Diseases | 2010
Brandon S. Schmit; Thomas M. Primus; Jerome C. Hurley; Dennis J. Kohler; Shawna F. Graves
A captive striped skunk (Mephitis mephitis) study was conducted between February and June 2004 at the United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services National Wildlife Research Center, Fort Collins, Colorado, USA. The main objective was to determine the percentage of adult striped skunks that were marked after consuming placebo oral rabies vaccine (ORV) baits containing 100 mg of an experimental microencapsulated (coated microparticle) tetracycline hydrochloride biomarker. Biomarkers were identified in the canine teeth and mandibles of five of five skunks that consumed an ORV bait. A second objective was to determine if the microencapsulated tetracycline was resistant to photochemical conversion from tetracycline to epitetracycline. After 15 days of exposure, conversion from tetracycline to epitetracycline concentration in the microencapsulated product (mean 1.9% conversion, SD=1.24) was significantly less (P=0.006) than the pure-grade tetracycline powder (mean 7.5% conversion, SD=1.37). Results support the use of microencapsulated tetracycline hydrochloride as a biomarker in circumstances where the use of conventional powdered tetracycline hydrochloride is not feasible due to ORV bait design constraints.
Journal of Wildlife Management | 2001
Peter J. Savarie; John A. Shivik; Gary C. White; Jerome C. Hurley; Larry Clark
Crop Protection | 2005
John J. Johnston; Dale L. Nolte; Bruce A. Kimball; Kelly R. Perry; Jerome C. Hurley
Journal of AOAC International | 2001
John J. Johnston; Margaret J. Goodall; Jerome C. Hurley; Christi A. Yoder; Lowell A. Miller
Journal of Agricultural and Food Chemistry | 1999
Jerome C. Hurley; Stephanie A. Volz; John J. Johnston
Archive | 2003
Richard E. Mauldin; Bruce A. Kimball; John J. Johnston; Jerome C. Hurley; Michael L. Avery
Archive | 2001
David A. Goldade; Peter J. Savarie; Jerome C. Hurley; Stanley A. Gaddis; John J. Johnston
Archive | 2012
Joanne L. Maki; Tricia L. Fry; Jerome C. Hurley; Lowell A. Miller