Jerry Cohen
Wayne State University
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Publication
Featured researches published by Jerry Cohen.
Clinica Chimica Acta | 1961
B. Zak; Jerry Cohen
Abstract A procedure for the determination of large volumes of micro quantities of protein (6.5–65 μg of N per ml) by automation has been described. The investigation covers the areas of specificity, precision, accuracy, stability and application. It is believed that this technic should be very useful for investigation of growth characteristics by tissue culture quantitation as well as for the several other areas previously mentioned.
Bioorganic & Medicinal Chemistry Letters | 1999
David J. Augeri; Dave Janowick; Douglas M. Kalvin; Gerry Sullivan; John J. Larsen; Daniel A. Dickman; H. Ding; Jerry Cohen; Jang Lee; Robert Warner; Peter Kovar; Sajeev Cherian; Badr Saeed; Haichao Zhang; Steve Tahir; Shi-Chung Ng; Hing L. Sham; Saul H. Rosenberg
Potent and orally bioavailable nonthiol-containing inhibitors of protein farnesyltransferase are described. Oral bioavailability was achieved by replacement of the pyridyl ether moiety of 1 with a 2-substituted furan ether to give 4. Potency was regained with 2,5-disubstituted furan ethers while maintaining the bioavailability inherent in 4. p-Chlorophenylfuran ether 24 is 0.7 nM in vitro (FTase) and is 32% bioavailable in the mouse, 30% bioavailable in rats, and 21% bioavailable in dogs.
Bioorganic & Medicinal Chemistry Letters | 2003
Yunsong Tong; Nan-Horng Lin; Le Wang; Lisa A. Hasvold; Weibo Wang; Nicholas M. Leonard; Tongmei Li; Qun Li; Jerry Cohen; Wen-Zhen Gu; Haiying Zhang; Vincent S. Stoll; Joy Bauch; Kennan C. Marsh; Saul H. Rosenberg; Hing L. Sham
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.
Bioorganic & Medicinal Chemistry Letters | 1999
Wang Shen; Stephen A. Fakhoury; Greg Donner; Kenneth J. Henry; Jang Lee; Haichao Zhang; Jerry Cohen; Robert Warner; Badr Saeed; Sajeev Cherian; Stephen K. Tahir; Peter Kovar; Joy Bauch; Shi-Chung Ng; Kennan C. Marsh; Hing L. Sham; Saul H. Rosenberg
Synthesis and biological evaluation of heteroarenes as reduced cysteine replacements are described. Of the heteroaryl groups examined with respect to FT inhibitor FTI-276 (1), pyridyl was the replacement found to be most effective. Substitutions at C4 of the pyridyl moiety did not affect the in vitro activity. Compound 9a was found to have moderate in vivo bioavailability.
Bioorganic & Medicinal Chemistry Letters | 2003
Nan-Horng Lin; Le Wang; Jerry Cohen; Wen-Zhen Gu; David J. Frost; Haiying Zhang; Saul H. Rosenberg; Hing L. Sham
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented.
Bioorganic & Medicinal Chemistry Letters | 1998
Wang Shen; David S. Garvey; Jerry Cohen; Herman H. Stein; Saul H. Rosenberg
Based on earlier lead squalene synthase inhibitor A-87049 (3) and zaragozic acids, a series of cyclopentanedi- and tricarboxylic acids were synthesized and evaluated against the enzyme. Some exhibited good potency and SAR revealed the importance of conformation and substitution pattern of these synthetic inhibitors.
Bioorganic & Medicinal Chemistry Letters | 2005
Qun Li; Tongmei Li; Keith W. Woods; Wen-Zhen Gu; Jerry Cohen; Vincent S. Stoll; Tomas Galicia; Charles W. Hutchins; David J. Frost; Saul H. Rosenberg; Hing L. Sham
Journal of Medicinal Chemistry | 1998
David J. Augeri; Stephen J. O'Connor; Dave Janowick; Bruce G. Szczepankiewicz; Gerry Sullivan; John J. Larsen; Douglas M. Kalvin; Jerry Cohen; Edward Devine; Haichao Zhang; Sajeev Cherian; Badr Saeed; Shi-Chung Ng; Saul H. Rosenberg
Bioorganic & Medicinal Chemistry Letters | 2005
Qun Li; Keith W. Woods; Weibo Wang; Nan-Horng Lin; Akiyo Claiborne; Wen-Zhen Gu; Jerry Cohen; Vincent S. Stoll; Charles W. Hutchins; David J. Frost; Saul H. Rosenberg; Hing L. Sham
Bioorganic & Medicinal Chemistry Letters | 2004
Qun Li; Akiyo Claiborne; Tongmei Li; Lisa A. Hasvold; Vincent S. Stoll; Steven W. Muchmore; Clarissa G. Jakob; Wendy Gu; Jerry Cohen; Charles W. Hutchins; David J. Frost; Saul H. Rosenberg; Hing L. Sham