Jerry D. Clark

The thermal stability of ethyl diazoacetate

Ethyl diazoacetate (EDA) is an important organic chemistry synthon, but its use as an industrial intermediate is limited due in part to the safety concerns associated with its instability and high reactivity. In a continuing effort to understand the risk of employing EDA as an industrial reagent, the thermal stability of EDA was studied. Reported are the results of accelerating rate and differential scanning calorimetry (DSC) experiments.

Detonation properties of ethyl diazoacetate

Ethyl diazoacetate is an important organic chemistry synthon, but its use as an industrial intermediate is limited due in part to the safety concerns associated with its instability and high reactivity. In a continuing effort to understand the risk of employing ethyl diazoacetate as an industrial reagent, detonation tests were completed. The results of these studies indicate that ethyl diazoacetate does not show detonation properties.

Understanding the large-scale chemistry of ethyl diazoacetate via reaction calorimetry

Ethyl diazoacetate is an important organic chemistry synthon, but its use as an industrial intermediate is limited due in part to the safety concerns associated with its instability and high reactivity. Reported are the reaction calorimetry results obtained from a new ethyl diazoacetate preparative method, the results from its use in a novel, exothermic reaction and the application of this data toward process development, a successful pilot plant campaign and full-scale reactor design. The results indicate that, given the proper engineering design, in situ preparation and use of ethyl diazoacetate solutions can be used at production scale without significant risk.

Application of reaction calorimetry toward understanding the large scale chemistry of ethyl diazoacetate

Ethyl diazoacetate is an important organic chemistry synthon, but its use as an industrial intermediate is limited due in part to the safety concerns associated with its instability and high reactivity. Reported are the reaction calorimetry results obtained from a new ethyl diazoacetate preparative method, the results from its use in a novel, exothermic reaction and the application of this data toward process development, a successful pilot plant campaign and full-scale reactor design. The results indicate that, given the proper engineering design, in situ preparation and use of ethyl diazoacetate solutions can be used at production scale without significant risk.