Jerry W. Skiles

Spiro indolinone beta-lactams, inhibitors of poliovirus and rhinovlrus 3C-proteinases

Preparation of the spiro beta-lactam 7 and its evaluation as a poliovirus and human rhinovirus 3C-proteinase inhibitor is described.

elastase inhibitors containing conformationally restricted lactams as P3-P2 dipeptide replacements

The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.

Imidazo[1,2-a]piperazines as mechanistic inhibitors of serine proteinases

Abstract The synthesis of imidazo[1,2-a]piperazines bearing a trifluoromethyl substituent, potential inhibitors of serine proteinases, is illustrated.