Jerzy Palus

Synthesis, spectroscopy and magnetic properties of cis-(9,10-dihydro-9-oxo-10-acridineacetato-μ-O)copper(II). An unusual carboxylate-bridged chain with very weak magnetic exchange

Abstract The synthesis, crystal structure, spectroscopic and magnetic properties are reported for Cu(CMA) 2 (H 2 O) 2 , where CMA − is the 9,10-dihydro-9-oxo-10-acridineacetate ion. The complex C 30 H 24 N 2 O 8 Cu crystallizes in the monoclinic space group C 2/ c , with cell dimensions a =17.700(7), b =19.266(8), c =7.424(4) A, β=91.88(4)°, Z =4. The structure was solved by direct methods and refined to a final R value of 0.035. The structure of Cu(CMA 2 )(H 2 O) 2 consists of unusual one-dimensional polymers which contain zigzag (CuO 2 CuO 2 ) chains and stacks of acridone moieties. The 9,10-dihydro-9-oxo-10-acridineacetate ion coordinates in the monodentate manner. Each copper ion shows distorted (4+2) octahedral coordination. The four short bonds come from two acetate oxygen and two water oxygen atoms. The long apical bonds are to the basal acetate oxygen atoms from neighboring copper centers. The angle at the oxygen, in the planar Cu 2 O 2 unit is 109.4(1)°, the CuCu distance is 3.967(3) A. The hydrogen atoms of each water molecule bind with the non-coordinated acetate oxygen atoms and 9-oxo oxygen atoms of the neighboring polymer. The acridone rings overlap with a 3.35 A interlayer separation. The magnetic susceptibility of the compound has been examined between 4.2 and 300 K. The compound behaves as an S =1/ 2 paramagnet. The absence of coupling arises from the unfavorable relative orientation of the magnetic orbitals. The EPR and LF spectra are typical of the distorted octahedral environment of copper(II) ion.

(N,N-diethylamino)alkoxy derivatives of phenanthrolines asDNA binding agents

The interaction of the tricyclic angular azaaromatic system having positive charged side chains withDNA, influence of molecular structure of the ligand on the mode of noncovalent binding, and stability of the complex formed were established. Several (N,N-diethylamino)alkoxy derivatives of 1,7-, 1,8-, 1,10- and 4,7-phenanthroline in the protonated form were used as ligand. The electronic and steric factors were shown as responsible for the electrostatic and intercalative interactions of the ligand withDNA. The syntheses of (N,N-diethylamino)alkoxy derivatives from parent phenanthrolines were elaborated.ZusammenfassungDie Wechselwirkung von trizyklischen, azaaromatischen Systemen mit positiver Ladung an Seitenketten mitDNA, der Einfluß der molekularen Struktur des Liganden bei nonkovalenter Bindung und die Stabilität des gebildeten Komplexes wurde bestimmt. Als Liganden wurden mehrere (N,N-diethylamino)alkoxy-Verbindungen von 1,7-, 1,8-, 1,10- und 4,7-Phenanthrolin in protonierter Form benutzt. Es wurde gezeigt, daß die elektronischen und sterischen Faktoren für elektrostatische und intercalative Wechselwirkungen des Ligand undDNA verantwortlich sind. Es wurden Synthesen von (N,N-diethylamino)alkoxy-phenanthrolinen aus entsprechenden Chlorverbindungen ausgearbeitet.

Hydrolysis driven surface activity of esterquat surfactants

HYPOTHESIS Surface activity of selected cleavable esterquat cationic surfactants is determined by the synergistic effect of surface active products of their hydrolysis. EXPERIMENTS Interfacial behavior of two classes of esterquat surfactants, quaternary alkylammmoniumesters and amino acid betaine (trimethylglycine) esters of fatty acids were examined both experimentally and theoretically. The surface tension measurements at air/water interface were performed by the pendant drop shape analysis method, then the obtained isotherms were theoretically described by the model of adsorption of ionic/non-ionic surfactants mixtures taking into account the presence of surface active products of surfactant hydrolysis. FINDINGS We found that surface activity of the mixture of surface active compounds resulting from the esterquat basic hydrolysis increases with time and it is higher when the ester carbonyl group is connected with the quaternary amine by bridging oxygen than in the inverted (betaine ester type) arrangement. That is, in the first case, the consequence of strong synergistic effect between the cationic esterquat surfactant and the anionic product of its hydrolysis - dodecanoate ion, while in the second case, the non-ionic hydrolysis product - dodecanol exhibits much weaker synergy. The addition of side CH3 group into the esterquat head-group slows down the hydrolysis that leads to the lower surface activity of the resulting mixture.

Bis(2-aminophenyl) Diselenide Derivatives with Amino Acids Moieties as Potential Antivirals and Antimicrobials

The seleno-organic compounds based on bis(2-aminophenyl) diselenide- 1 are potential antiviral, antibacterial and antifungal agents. 1 In this work, we reported synthesis of bis(2-aminophenyl) diselenide derivatives 2 , 3 having amino acid and dipeptide moieties. This process was realized by acylation of amine groups in 1 with N-blocked amino acids, using the active esters method (with DCC and HOBT). After removing protective groups successive N-blocked amino acids were added the same way as previously. All compounds have been tested against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (HSV-1, EMCV, VSV), in vitro. Most of them exhibited high activity against EMCV. Some of tested compounds were active against gram-positive bacteria species (Staphylococcus aureus, Staphylococcus simulans) and yeast Candida albicans.