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Dive into the research topics where Jerzy Żabiński is active.

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Featured researches published by Jerzy Żabiński.


Bioorganic & Medicinal Chemistry | 2015

Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors

Michael L. Berger; Dorota Maciejewska; Jean Jacques Vanden Eynde; Madhusoodanan Mottamal; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Ivana Jarak; Ivo Piantanida; Grace Karminski-Zamola; Annie Mayence; Patrick Rebernik; Arvind Kumar; Mohamed A. Ismail; David W. Boykin; Tien L. Huang

The anti-protozoal drug pentamidine is active against opportunistic Pneumocystis pneumonia, but in addition has several other biological targets, including the NMDA receptor (NR). Here we describe the inhibitory potencies of 76 pentamidine analogs at 2 binding sites of the NR, the channel binding site labeled with [(3)H]MK-801 and the [(3)H]ifenprodil binding site. Most analogs acted weaker at the ifenprodil than at the channel site. The spermine-sensitivity of NR inhibition by the majority of the compounds was reminiscent of other long-chain dicationic NR blockers. The potency of the parent compound as NR blocker was increased by modifying the heteroatoms in the bridge connecting the 2 benzamidine moieties and also by integrating the bridge into a seven-membered ring. Docking of the 45 most spermine-sensitive bisbenzamidines to a recently described acidic interface between the N-terminal domains of GluN1 and GluN2B mediating polyamine stimulation of the NR revealed the domain contributed by GluN1 as the most relevant target.


Monatshefte Fur Chemie | 2006

Pentamidine Analogs: Syntheses, Structures in Solid State by 13C CP/MAS NMR Spectroscopy, and X-Ray Crystallography and their Preliminary Biological Screening Against Human Cancer

Dorota Maciejewska; Paweł Kaźmierczak; Jerzy Żabiński; Irena Wolska; Sylwia Popis


European Journal of Medicinal Chemistry | 2012

Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics

Dorota Maciejewska; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Barbara Krassowska-Świebocka; Margaret S. Collins; Melanie T. Cushion


Journal of Molecular Structure | 2007

Comparison of structure in solid state of new 1,5-bis(4-cyano-2,6-dimethoxyphenoxy)alkanes by means of 13C CP/MAS NMR and X-ray diffraction

Jerzy Żabiński; Irena Wolska; Dorota Maciejewska


Journal of Molecular Structure | 2010

Solid state structural analysis of new pentamidine analogs designed as chemotherapeutics that target DNA by X-ray diffraction and 13C, 15N CP/MAS NMR methods

Jerzy Żabiński; Dorota Maciejewska; Irena Wolska


Journal of Molecular Structure | 2009

Structural analysis of bis-amidines and bis-nitriles in solid-state by combining NMR spectroscopy and molecular modeling

Jerzy Żabiński; Dorota Maciejewska; Paweł Kaźmierczak


Journal of Molecular Structure | 2008

Examination of the structure in solid state of amino analogs of 4,4′-[1,5-pentanediylbis(oxy)]bisbenzonitrile by means of X-ray diffraction, 13C CP/MAS NMR, and theoretical calculations

Dorota Maciejewska; Irena Wolska; Jerzy Żabiński


Bioorganic & Medicinal Chemistry Letters | 2014

In vitro screening of pentamidine analogs against bacterial and fungal strains

Dorota Maciejewska; Jerzy Żabiński; Paweł Kaźmierczak; Karolina Wójciuk; Marcin Kruszewski; Hanna Kruszewska


Molecules | 2015

Probing the Relationship between Anti-Pneumocystis carinii Activity and DNA Binding of Bisamidines by Molecular Dynamics Simulations

Teresa Żołek; Dorota Maciejewska; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler


MedChemComm | 2017

Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity

Dorota Maciejewska; Jerzy Żabiński; Mateusz Rezler; Paweł Kaźmierczak; Margaret S. Collins; L. Ficker; Melanie T. Cushion

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Dorota Maciejewska

Medical University of Warsaw

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Paweł Kaźmierczak

Medical University of Warsaw

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Irena Wolska

Adam Mickiewicz University in Poznań

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Mateusz Rezler

Medical University of Warsaw

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Margaret S. Collins

University of Cincinnati Academic Health Center

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Melanie T. Cushion

University of Cincinnati Academic Health Center

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Sylwia Popis

Medical University of Warsaw

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Teresa Żołek

Medical University of Warsaw

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Annie Mayence

Xavier University of Louisiana

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