Jerzy Żabiński
Medical University of Warsaw
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Featured researches published by Jerzy Żabiński.
Bioorganic & Medicinal Chemistry | 2015
Michael L. Berger; Dorota Maciejewska; Jean Jacques Vanden Eynde; Madhusoodanan Mottamal; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Ivana Jarak; Ivo Piantanida; Grace Karminski-Zamola; Annie Mayence; Patrick Rebernik; Arvind Kumar; Mohamed A. Ismail; David W. Boykin; Tien L. Huang
The anti-protozoal drug pentamidine is active against opportunistic Pneumocystis pneumonia, but in addition has several other biological targets, including the NMDA receptor (NR). Here we describe the inhibitory potencies of 76 pentamidine analogs at 2 binding sites of the NR, the channel binding site labeled with [(3)H]MK-801 and the [(3)H]ifenprodil binding site. Most analogs acted weaker at the ifenprodil than at the channel site. The spermine-sensitivity of NR inhibition by the majority of the compounds was reminiscent of other long-chain dicationic NR blockers. The potency of the parent compound as NR blocker was increased by modifying the heteroatoms in the bridge connecting the 2 benzamidine moieties and also by integrating the bridge into a seven-membered ring. Docking of the 45 most spermine-sensitive bisbenzamidines to a recently described acidic interface between the N-terminal domains of GluN1 and GluN2B mediating polyamine stimulation of the NR revealed the domain contributed by GluN1 as the most relevant target.
Monatshefte Fur Chemie | 2006
Dorota Maciejewska; Paweł Kaźmierczak; Jerzy Żabiński; Irena Wolska; Sylwia Popis
European Journal of Medicinal Chemistry | 2012
Dorota Maciejewska; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Barbara Krassowska-Świebocka; Margaret S. Collins; Melanie T. Cushion
Journal of Molecular Structure | 2007
Jerzy Żabiński; Irena Wolska; Dorota Maciejewska
Journal of Molecular Structure | 2010
Jerzy Żabiński; Dorota Maciejewska; Irena Wolska
Journal of Molecular Structure | 2009
Jerzy Żabiński; Dorota Maciejewska; Paweł Kaźmierczak
Journal of Molecular Structure | 2008
Dorota Maciejewska; Irena Wolska; Jerzy Żabiński
Bioorganic & Medicinal Chemistry Letters | 2014
Dorota Maciejewska; Jerzy Żabiński; Paweł Kaźmierczak; Karolina Wójciuk; Marcin Kruszewski; Hanna Kruszewska
Molecules | 2015
Teresa Żołek; Dorota Maciejewska; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler
MedChemComm | 2017
Dorota Maciejewska; Jerzy Żabiński; Mateusz Rezler; Paweł Kaźmierczak; Margaret S. Collins; L. Ficker; Melanie T. Cushion