Jeseung Oh

A carbon nanotube metal semiconductor field effect transistor-based biosensor for detection of amyloid-beta in human serum.

We have developed a carbon nanotube (CNT) film-based biosensor with a metal semiconductor field effect transistor structure (MESFET). A gold top gate was deposited on the middle of the CNT channel and probe antibodies were immobilized on the gold top gate with an antibody-binding protein, protein G or Escherichia coli outer membrane (OM) with autodisplayed Z-domains of protein A. These CNT-MESFET biosensors exhibited a higher sensitivity than the CNT-FET biosensor with probe antibodies immobilized using a chemical linker, since the orientation of immobilized antibodies was controlled by the antibody-binding proteins. In addition, nonspecific binding was effectively inhibited by E. coli OM. Using the CNT-MESFET biosensors with E. coli OM containing Z domain, we detected amyloid-β (Aβ) in human serum, one of the biomarkers for early diagnosis of Alzheimers disease. Aβ at the level of 1 pg/mL in human serum could be measured in real-time and without labeling, which was lower than a limit of detection for plasma Aβ using an enzyme-linked immune sorbent assay. These results suggested that our CNT-MESFET biosensors might be applicable for an early diagnosis of Alzheimers disease.

Carbon Nanotube-Based Dual-Mode Biosensor for Electrical and Surface Plasmon Resonance Measurements

We have developed carbon nanotube-based dual-mode biosensors with a metal semiconductor field effect transistor structure on a quartz substrate. DNA hybridization occurring on the Au top gate can be detected by simultaneously measuring the change in the electrical conductance and the surface plasmon resonance (SPR). Since electrical and SPR measurements offer high sensitivity and reliability, respectively, this dual-mode biosensor is expected to provide both of these features.

Development of Rotary-Type Voice Coil Motor Actuator for Small-Form-Factor Optical Disk Drive

We propose the miniaturized rotary-type voice coil motor (VCM) actuator that has an effective focusing mechanism and a sufficient bandwidth for a small-form-factor (SFF) optical disk drive (ODD) based on Blu-ray disk (BD) 1× specifications.

Near-infrared photodetectors utilizing MoS2-based heterojunctions

Near-infrared photodetectors are developed using graphene/MoS2 and WSe2/MoS2 vertical heterojunctions. These heterojunctions exhibit diode-rectifying behavior in the dark and enhanced photocurrent upon near-infrared irradiation. The photocurrent increases with increasing near-infrared power, leading to the photoresponsibility of 0.14 and 0.3 A W−1 for the graphene/MoS2 and WSe2/MoS2 heterojunctions, respectively, which are much higher than the photoresponsibility reported for a multilayer MoS2 phototransistor.

Aptamer-functionalized capacitance sensors for real-time monitoring of bacterial growth and antibiotic susceptibility

To prevent spread of infection and antibiotic resistance, fast and accurate diagnosis of bacterial infection and subsequent administration of antimicrobial agents are important. However, conventional methods for bacterial detection and antibiotic susceptibility testing (AST) require more than two days, leading to delays that have contributed to an increase in antibiotic-resistant bacteria. Here, we report an aptamer-functionalized capacitance sensor array that can monitor bacterial growth and antibiotic susceptibility in real-time. While E. coli and S. aureus were cultured, the capacitance increased over time, and apparent bacterial growth curves were observed even when 10 CFU/mL bacteria was inoculated. Furthermore, because of the selectivity of aptamers, bacteria could be identified within 1h using the capacitance sensor array functionalized with aptamers. In addition to bacterial growth, antibiotic susceptibility could be monitored in real-time. When bacteria were treated with antibiotics above the minimum inhibitory concentration (MIC), the capacitance decreased because the bacterial growth was inhibited. These results demonstrate that the aptamer-functionalized capacitance sensor array might be applied for rapid ASTs.

Magnetic nanoparticle-based separation of metallic and semiconducting carbon nanotubes

We report a simple and scalable method for the separation of semiconducting single-walled carbon nanotubes (SWNTs) from metallic SWNTs using magnetic nanoparticles (MNPs) functionalized with polycationic tri-aminated polysorbate 80 (TP80). MNPs-TP80 are selectively adsorbed on acid-treated semiconducting SWNTs, which makes the semiconducting SWNTs be highly concentrated to over 95% under a magnetic field. Almost all the field effect transistor network devices, which were fabricated using separated semiconducting SWNTs, exhibited a p-type semiconducting behavior with an on/off ratio of higher than 10(4).

Design of Rotary Type VCM Actuator for SFF ODD

We proposed the miniaturized rotary type VCM actuator that had an effective focusing mechanism and secured sufficient bandwidth for small form factor optical disk drive.

Numerical Simulation of a DNA Sensor Based on the CNT-Gold Island Structure

A numerical simulation has been performed for the DNA sensors based on the field-effect-transistor (FET) structure of a CNT with the gold island- attached on the CNT tube. The model uses the Poisson-drift-diffusion theory for the CNT transistor and considers the charge exchange between the interfaces between the CNT and gold island, gold and the linker molecules. In order to compare with experiments, an example device is simulated to predict the response of the sensor to the target DNAs in both the air and aqueous solution.

Design of Swing Arm Type`s Actuator for Small-sized ODD

Recently, the need for subminiature storage systems has increased with the diversification of portable devices. An actuator for small optical disk drives has to satisfy performance requirements such as higher access speed, lower power consumption, and smaller size. In this paper, we proposed the miniaturized rotary type VCM actuator that had an effective focusing mechanism and secured sufficient bandwidth for small form factor (SFF) optical disk drive (ODD). Initial model was designed by electromagnetic (EM) and structural analyses. Such a model was improved using design of experiments (DOE) procedure based on a Blu-ray disk (BD) 1x specifications.