Jesmine Khan

Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

© 2012 Khan and Nasimul Islam , licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

Leave Methamphetamine to be alive – Part II

Series of experiments have been completed with Methamphetamine (MA). Some were with the higher, medium or lower duration of MA administration and some were with acute or chronic doses. Whatever may be the dose or duration the ultimate result came out with the further establishment of cardio-toxic effect of this drug. Cardiovascular symptoms related to MA toxicity include chest pain, palpitations, dyspnoea, hypertension, tachycardia, atrial and ventricular arrhythmias, and myocardial ischemia. MA abusers often go through a repeated pattern of frequent drug administrations followed by a period of abstinence. Previous studies have focused largely upon the chronic effect of MA intake to major organs, such as the brains and the heart, by using animal experiments. However, there is a lack of research into the effects of acute dose of MA, especially pertaining to the heart. To clarify the effect of MA on myocardium, 22 male Wister rats aged six weeks were divided into MA, Placebo (P) and Control (C) group were examined following single intraperitoneal administration of MA at a dose of 50 mg/kg body weight. Normal saline was similarly injected in P group. Light microscopic changes was seen in the myocardium of MA treated group including cellular infiltration, with clusters of macrophage-like cells having large nuclei and little cytoplasm evident in the sub-endocardium region. There were presence of few macrophages, leucocytes, and spindle-like fibroblasts. Bringing in to account of cardiac changes by a single dose of MA, slogan should be voiced out to leave methamphetamine.

Digital Autopsy: Popular Tools for an Unpopular Procedure

Digital autopsy is the future of postmortem examination of the human body through digital visualization. Imaging modalities such as CT scanners and MRI scanners use X rays and magnetic fields to visualize the structures within the human body. The outputs from these modalities are obtained in a DICOM (Digital Imaging and Communications of Medicine) format. They are in gray-scale consisting of information in every slice taken during the scan. This is rendered and visualized as the full body in a digital format during the digital autopsy procedure. The visualization rendering produces a three-dimensional body, further presented in colour format based on each structure of the human organ system. Digital autopsy is a technology which allows pathologists to navigate and explore deeper into the human body. It allows analysis to be done in both two-dimensional and three dimensional perspectives. Digital autopsy involves analysis of human pathology and anatomical findings for diagnostic purposes. It can also be used for education and research purposes. Another advantage of digital autopsy is the availability of information and data that can be easily and securely transferred to a different digital autopsy facility at a different location. Thus, digital autopsy provides an efficient, fast, cheaper and accurate post-mortem data enabling a forensic pathologists to play a more effective role in the criminal justice system.