Ji-In Kim Almstead

Synthesis and biological testing of non-Fluorinated analogues of levofloxacin

Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the antibacterial quinolone Levofloxacin were synthesized and tested.

An investigation into the total synthesis of clerocidin: stereoselective synthesis of a clerodane intermediate

Abstract A key clerodane intermediate was prepared during the investigation of the total synthesis of clerocidin. The diterpene backbone was synthesized by an enantioselective Robinson annulation followed by trapping of the enolate using allyl bromide. Selective hydrogenation conditions were developed to introduce the axial methyl group at the C8 position. A palladium-mediated carbonylation reaction was employed to generate the key α,β-unsaturated dialdehyde.