Ji-Wook Yang
Catholic University of Korea
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Publication
Featured researches published by Ji-Wook Yang.
Journal of Cataract and Refractive Surgery | 2008
Su-Young Kim; Ji-Wook Yang; Young-Chun Lee; Young-Hoon Park
PURPOSE: To assess the effect of a single intraoperative sub‐Tenon injection of triamcinolone acetonide on the progression of diabetic retinopathy (DR), visual outcomes, and cystoid macular edema (CME) after cataract surgery. SETTING: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea. METHODS: This prospective controlled study comprised 46 eyes of 23 diabetic patients. The control group comprised eyes not treated with a triamcinolone acetonide injection, and the triamcinolone group comprised contralateral eyes treated with a single posterior sub‐Tenon injection of triamcinolone acetonide at the end of cataract surgery. The visual acuity, central macular thickness (CMT) by optical coherence tomography, and progression of DR were compared between the 2 groups. RESULTS: One month postoperatively, the mean change in lines of best corrected visual acuity was significantly greater in the triamcinolone group (P = .045) and the mean change in CMT was significantly greater in the control group (P = .015). The incidence of CME was higher in the control group (P = 0.04). Scores for progression of DR at 6 months were not statistically significantly different between the 2 groups (P = 0.08). CONCLUSIONS: A posterior sub‐Tenon injection of triamcinolone acetonide lowered the incidence of CME after cataract surgery in diabetic patients, improved visual recovery, and reduced the amount of CMT increase in the short term (≤1 month postoperatively). However, triamcinolone acetonide did not affect DR progression over the 6‐month follow‐up.
Current Eye Research | 2011
Su-Young Kim; Ji-Wook Yang; Young-Chun Lee
Purpose: We wanted to investigate the effect of nicergoline on corneal nerve regeneration in rat corneas after photorefractive keratectomy (PRK). Methods: Twenty Sprague–Dawley male rats were divided into two groups, the control group and the group that had been treated with nicergoline for 4 weeks. Corneal wound healing was evaluated by fluorescein staining after PRK. Immunofluorescent staining was performed in the rat corneas at 1 month after PRK with monoclonal antibodies for class III β-tubulin, calcitonin gene-related peptide (CGRP), and substance P (SP). The stained nerve areas were calculated using an image-analysis program. Results: The corneal wound healing rate was not significantly different between the nicergoline-treated rats and the control rats after PRK. At 1 month after PRK, the tubulin-positive, substance P-positive, and CGRP-positive nerve areas were significantly greater in the treatment group than those in the control group. Conclusion: Nicergoline treatment increased the corneal nerve area in the rats after they had undergone PRK. Nicergoline may help patients who have a decreased corneal sense, such as those with neurotrophic keratopathy and those patients after they undergo refractive surgery.
Journal of Ocular Pharmacology and Therapeutics | 2010
Su-Young Kim; Ji-Wook Yang; Young-Chun Lee
PURPOSE The aim of this study was to evaluate the safety of moxifloxacin and voriconazole as a supplement in corneal storage media for porcine corneal endothelial cells. METHODS Twenty-eight eyes were divided into 4 groups. In the control group (the C group), corneal buttons were stored for 3 days in Optisol-GS. In the treatment group, the corneal buttons were preserved for 3 days in Optisol-GS mixed with 250 microg/mL moxifloxacin (M group), 100 microg/mL voriconazole (V group), and 250 microg/mL moxifloxacin plus 100 microg/mL voriconazole (MV group). We evaluated the samples via specular microscopy before and after 3 days of preservation. The mean changes of endothelial cell counts were compared among the 4 groups. Scanning electron microscopy was conducted after 3 days of preservation. RESULTS Before the preservation, the endothelial cell counts did not differ among the 4 groups (P > 0.05). After 3 days of preservation, the endothelial cell count in the MV group was the lowest among the 4 groups (P < 0.05). After 3 days of preservation, the rate of corneal endothelial cell loss in the M and V groups did not differ significantly from the control group (P > 0.05). The rate of endothelial cell loss in the MV group was significantly higher than that of the control group (P < 0.05). Scanning electron microscopy revealed a normal mosaic pattern for the C, V, and F groups, but hexagonality was not preserved in the MV group. CONCLUSION Preservation in Optisol-GS mixed with moxifloxacin (250 microg/mL) plus voriconazole (100 microg/mL) induced significant toxicity on the endothelial cells in porcine corneas, when compared with the control group.
Retina-the Journal of Retinal and Vitreous Diseases | 2015
Soyoon Kim; Jeong Ah Shin; Hae-Ri Yum; Jae Hyung Han; Ji-Wook Yang; Young-Hoon Park
Purpose: To evaluate the long-term effect of vitrectomy by itself and combined vitrectomy with sub-Tenon injection of triamcinolone acetonide (TA) on intraocular pressure (IOP). Methods: In a retrospective cohort study, the medical records of 56 eyes of 56 patients who underwent nonemergent vitrectomy and were followed up for at least 24 months were reviewed. Thirty-two eyes of 32 patients underwent combined vitrectomy with sub-Tenon injection of TA. Twenty-four eyes of 24 patients underwent vitrectomy only. Increased IOP of >4 mmHg from the baseline, change in IOP from the baseline, and preoperative and postoperative measured IOPs were recorded and compared between the two groups, and with fellow eyes. Results: Minimum follow-up period was 24 months. Except the IOP at postoperative 1 day, there were no significant differences between vitrectomized eyes and nonvitrectomized fellow eyes. There were also no differences between vitrectomized eyes and eyes that underwent combined vitrectomy with sub-Tenon injection of TA. And in the comparison of the vitrectomy-only eye group and the vitrectomy with sub-Tenon TA eye group, there was also no significant difference during the whole follow-up period. Conclusion: Vitrectomy by itself or combined vitrectomy with sub-Tenon injection of TA does not seem to increase IOP in the long term.
Journal of The Korean Ophthalmological Society | 2010
Ji-Wook Yang; Young-Chun Lee
Journal of The Korean Ophthalmological Society | 2008
Ji-Wook Yang; Seung-Jin Lee; Seungbum Kang; Young-Hoon Park
Journal of The Korean Ophthalmological Society | 2009
Ji-Wook Yang; Wung-Jae Kim; Young-Hoon Park
Journal of The Korean Ophthalmological Society | 2008
Ji-Wook Yang; Young-Hoon Park
Journal of The Korean Ophthalmological Society | 2002
Ji-Wook Yang; Hyun-Seung Kim; Young-Chun Lee
Investigative Ophthalmology & Visual Science | 2013
Young-Hoon Park; Soyoon Kim; Ji-Wook Yang