Jia Ming Qian

Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.

OBJECTIVE:  Colon cancer is more common in the USA and Europe than that in China, for reasons that are unclear. The aim of this study was to investigate the differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.

Vitamin D levels and bone metabolism in Chinese adult patients with inflammatory bowel disease

We aimed to investigate the serum 25‐hydroxyvitamin D3 (25[OH]D3) levels and bone metabolism in adult Chinese patients with inflammatory bowel disease (IBD) and to evaluate the correlation between vitamin D levels and the disease activity as well as the potential risk factors.

Discriminating Potential of Extraintestinal Systemic Manifestations and Colonoscopic Features in Chinese Patients with Intestinal Behçet's Disease and Crohn's Disease

Background: The distinction between intestinal Behçets disease (BD) and Crohns disease (CD) is always challenging due to many overlapping clinical features. We conducted a retrospective study to reveal valuable strategies for the differential diagnosis between intestinal BD and CD in Chinese patients based on their clinical and colonoscopic features. Methods: Thirty-five intestinal BD patients and 106 CD patients hospitalized from January 1983 to January 2010, who had ulcerative lesions in the terminal ileum or colon under colonoscopy and no history of gastrointestinal operation except appendectomy before admission, were enrolled. Univariate and multivariate logistic regression analyses were conducted to find discriminating predictors among demographic data, clinical manifestations, and colonoscopic findings. Results: Based on univariate analysis, massive gastrointestinal hemorrhage, fever, and extraintestinal systemic manifestations were more common in intestinal BD patients (P = 0.022, 0.048 and 0.001, respectively), while diarrhea, intestinal obstruction, and perianal lesions were more common in CD patients (P = 0.002, 0.010, and 0.027 respectively). Based on colonoscopy, focal involvement, ileocecal valve deformity, solitary ulcers, large ulcers (ulcer size > 2 cm), and circumferential ulcers were more common in intestinal BD patients (P = 0.003, 0.003, 0.014, 0,013, and 0.003, respectively), while segmental involvement, longitudinal ulcers, a cobblestone or nodular appearance, and pseudo-polyps were more common in CD patients (P = 0.003, 0.008, 0.023, and 0.002, respectively). Based on multivariate logistic regression analysis, diarrhea, extraintestinal manifestations, ulcer distribution, size, and type, and pseudo-polyps were independent discriminating predictors between the two groups (P = 0.048, 0.008, 0.006, 0.021, 0.002, and 0.041, respectively). The discriminating algorithm composed of the above independent predictors had the highest area under the curve of 0.987 for distinguishing between the two diseases. Conclusions: Extraintestinal systemic manifestations and the characteristic colonoscopic features, such as ulcer distribution, size and type, helped to distinguish intestinal BD from CD.

Risk factors of acute pancreatitis in the elderly Chinese population: A population‐based cross‐sectional study

Lifestyle changes have led to an increasing incidence of acute pancreatitis (AP) in China. The aims of this study were to evaluate the association between lifestyle as well as medical history and AP in the elderly population and to provide evidence towards the prevention against AP.

Recurrence of Helicobacter pylori infection and the affecting factors: a follow-up study.

Recurrence of Helicobacter pylori (H. pylori) infection weakens the protective effect and long‐term prognosis of eradication. With the widespread therapies, decreasing prevalence of H. pylori infection and improvement in living conditions, the recurrence of H. pylori infection may present with new features. We conducted this prospective, large‐scale, multicenter follow‐up study to determine the recurrence rate of H. pylori infection and its affecting factors.

IgG4‐related sclerosing cholangitis with autoimmune pancreatitis and periaortitis: Case report and review of the literature

Immunoglobulin G4 (IgG4)-related systematic disease (IgG4-RSD) is a systemic fibroinflammatory condition characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs including pancreas, bile duct, gallbladder, salivary glands, kidney, lung, prostate, retroperitoneum and even the thyroid gland. It may affect one or two and sometimes more than three organs. Early diagnosis and treatment could not prevent sclerosis and permanent damage of the affected organ but also avoid other organ involvement. Here we present a rare case of IgG4-RSD affecting pancreas, biliary duct system and abdominal aorta. A review of the literature was also made mainly concerning IgG4-related sclerosing cholangitis (IgG4-SC) and periaortitis.

Treatment efficacy and safety of low-dose azathioprine in chronic active ulcerative colitis patients: A meta-analysis and systemic review.

To evaluate the efficacy and safety of low‐dose azathioprine (AZA) in treating patients with chronic active ulcerative colitis (UC).

Clinicopathological features of primary gastric neuroendocrine neoplasms: a single‐center analysis

To assess the clinical characteristics, diagnosis and therapeutic modalities for gastric neuroendocrine neoplasms (GNENs) among the Chinese population in a single institution.

Standard dose versus low dose of azathioprine in the treatment of Crohn's Disease: a prospective randomized study.

Azathioprine (AZA) is widely used to treat Crohns disease (CD) with a recommended dose of 2–2.5 mg/kg per day for Westerners. Asian patients are suggested to take a lower dose. However, many clinicians reported poor efficacy with a reduced dose. This study aimed to explore a efficient and safe dose of AZA providing the best efficacy for Chinese CD patients.

Treatment of vitamin D deficiency in Chinese inflammatory bowel disease patients: A prospective, randomized, open-label, pilot study: Vitamin D supplementation in IBD

To assess the necessity and efficacy of vitamin D (VitD) supplementation in Chinese ulcerative colitis (UC) and Crohn’s disease (CD) patients with vitamin D insufficiency/deficiency.