加藤 隆一

2.拘束ストレスによるラット視床下部におけるモノアミン代謝の亢進ならびに血漿ACTHの増加におけるインターロイキン-1の関与

We investigated whether pretreatment with an interleukin-1 receptor antagonist (IL-1RA) is capable of inhibiting immobilization stress (IS) -induced elevations of hypothalamic norepinephrine (NE) and the levels of their metabolites as well as the plasma adrenocorticotropic hormone (ACTH) . IL-1 RA was administered directly into the anterior hypothalamus, and monoamines were determined using a microdialysis technique and an HPLC system. IL-1 RA (2μg) significantly inhibited IS-induced increases in hypothalamic NE level. In addition, IL-1RA (2μg) also inhibited the IS-induced elevation of plasma ACTH levels. In summary, these results suggest that hypothalamic interleukin-1 (IL-1) plays a role in the regulation of IS-induced responses including elevated monoamine release in the hypothalamus and activation of the hypothalamo-pituitary-adrenal axis.