Jian-Hai Ding

Twelve new compounds from the basidiomycete Boreostereum vibrans

Seven cadinane sesquiterpenoids, named boreovibrins A–G (1–7), three dihydrobenzofurans (8–10), and two lactones (11 and 12), together with one known compound (13), were isolated from cultures of the basidiomycete Boreostereum vibrans. The new structures were elucidated by means of spectroscopic methods. Compounds 5, 6, and 11 showed weak inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD).Graphical abstract

Three new compounds from the cultures of basidiomycete Boreostereum vibrans

Three new compounds, vibranether (1), myrrhlalkyldiol (2), vibralactone H (3), together with three known compounds, 2-methyl-6-p-tolylheptane-2,3-diol (4), 2-hydroxy-2-methyl-6-p-tolylheptan-3-one (5), and vibralactone (6), were isolated from the cultures of the basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic evidences (1D and 2D NMR, HRMS, UV, and IR data), chemical methods, and the literature data. The new compounds displayed no significant cytotoxicities against five human cancer cell lines (IC50>40 μM).

Chemical constituents from cultures of the basidiomycete Trichaptum pargamenum

Four cadinane-type sesquiterpenes and four 13-carbon γ-lactones, together with three known compounds, were isolated from cultures of the basidiomycete Trichaptum pargamenum. Their structures were elucidated on the basis of extensive spectroscopic methods. The absolute configurations of two of the cadinene type sesquiterpenes 1 and 3 were confirmed by single crystal X-ray diffractions.

Five new 5,6-seco-tremulane sesquiterpenoids from the basidiomycete Conocybe siliginea

Five new 5,6-seco-tremulane sesquiterpenoids (1–5), as well as three known analogues (6–8), were isolated from the basidiomycete Conocybe siliginea. The structures of new compounds were elucidated by extensive spectroscopic methods. The known compounds were identified by comparing their spectroscopic data with those reported in the literature.

Two new drimane sesquiterpenoids from cultures of the basidiomycete Trichaptum biforme

Two new drimane sesquiterpenoids (1 and 2), as well as five known compounds (3–7), were isolated from the basidiomycete Trichaptum biforme. The structures of new compounds were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparing their spectroscopic data with those reported in the literature. The cytotoxicities results against five human cancer cell lines of compounds 1 and 2 were negligible.

Two new sesquiterpenes from cultures of the basidiomycete Agaricus arvensis

Two new drimane sesquiterpenoids, 11,12-dihydroxy-15-drimeneoic acid (1) and 3α,11,15-trihydroxydrimene (2), were isolated from cultures of the basidiomycete Agaricus arvensis, together with one known compound 3β,11,12-trihydroxydrimene (3). Their structures were established by means of spectroscopic analysis.

Four new sesquiterpenoids from cultures of the fungus Funalia trogii

Four new drimane sesquiterpenoids, named as funatrols A–D (1–4), together with isodrimenediol (5), were isolated from cultures of the fungus Funalia trogii. The new structures were elucidated by means of spectroscopic methods. All compounds were tested for their cytotoxicities against five human cancer cell lines.

Two new rearranged abietane diterpenoids from tropical Isodon coetsa

Two new rearranged abietane diterpenoids, sincoetsin A (1) and sincoetsin B (2), were isolated from the aerial part of Isodon coetsa (Buth-Ham ex D.Don) Hara collected in Singapore, and their structures were determined by spectroscopic methods, especially 2D NMR techniques.

Three new phenyl-ethanediols from the fruiting bodies of the mushroom Fomes fomentarius

Three new phenyl-ethanediols, (1R)-(3-ethenylphenyl)-1,2-ethanediol (1), (1R)-(3-formylphenyl)-1,2-ethanediol (2), and (1R)-(3-acetophenyl)-1,2-ethanediol (3), were isolated from the fruiting bodies of the mushroom Fomes fomentarius, together with two related known compounds, (3-ethylphenyl)-1,2-ethanediol (4) and (4-acetophenyl)-1,2-ethanediol (5). Their structures were elucidated by spectroscopic methods including extensive 2D NMR techniques. Compounds 1–3 showed weak antimicrobial activity.