Jian-Siang Poh

A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions.

Abstract Coupling of readily available boronic acids and diazo compounds has emerged recently as a powerful metal‐free carbon–carbon bond forming method. However, the difficulty in forming the unstable diazo compound partner in a mild fashion has hitherto limited their general use and the scope of the transformation. Here, we report the application of oxadiazolines as precursors for the generation of an unstable family of diazo compounds using flow UV photolysis and their first use in divergent protodeboronative and oxidative C(sp2)−C(sp3) cross‐coupling processes, with excellent functional‐group tolerance.

Research data supporting "A multicomponent approach for the preparation of homoallylic alcohols"

This data contains a .zip file of the NMR spectra for the compounds (in .mnova format, to be opened in MestReNova) described in the Supporting Information. It also contains a .pdf copy of the Supporting Information, which contains the experimental details and full characterisation data (NMR, IR, HRMS) of all compounds produced in this publication.

Research data supporting “Rapid asymmetric disubstituted allene synthesis via coupling of flow-generated diazo compounds and propargylated amines”

This data contains a .zip file of the NMR spectra for the compounds (in .mnova format, to be opened in MestReNova) described in the Supporting Information. It also contains a .pdf copy of the Supporting Information, which contains the experimental details and full characterisation data (NMR, IR, HRMS) of all compounds produced in this publication.