Jiang Hualiang
Chinese Academy of Sciences
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Publication
Featured researches published by Jiang Hualiang.
Bioorganic & Medicinal Chemistry Letters | 1998
Zeng Fanxing; Jiang Hualiang; Tang Xican; Chen Kaixian; Ji Ruyun
Abstract The synthesis of (±)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (−)-huperzine A.
Science China-chemistry | 2012
Lin Daizong; Qian WangKe; Hilgenfeld Rolf; Jiang Hualiang; Chen Kaixian; Liu Hong
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
Chinese Science Bulletin | 2017
Zheng Mingyue; Liu Gang; Tang Wei; Zuo Jianping; Zhang Ao; Jiang Hualiang
Artemisinin is a sesquiterpene lactone compound containing a peroxy bridge structure, extracted from Compositae Artemisia annua L. in 1971. Discovered by Chinese researchers, artemisinin and its derivatives are currently the most effective drugs in the world for the treatment of chloroquine-resistant Plasmodium falciparumstrains and cerebral malaria. As first-line antimalarial medicines, artemisinin and its derivatives have saved millions of lives, and artemisinin has been reputed as “the best hope for malaria treatment” by World Health Organization. At Nobel Prize Award Ceremony in 2015, Tu Youyou, a natural product medicinal chemist at the China Academy of Chinese Medical Sciences who made significant contribution to the discovery of artemisinin as an antimalarial drug, delivered a speech entitled “Artemisinin—A gift from traditional Chinese medicine to the world”. Tu said: “From research experience gained from artemisinin discovery, we learnt strengths of both Chinese and Western medicines. There is great potential and future advances if these strengths can be fully integrated. We have a substantial amount of natural resource from which our fellow medical researchers can develop novel medicines”. Doubtless the discovery of artemisinin represents a banner in the history of Chinese pharmaceutical industry, which is of immense significance both to enlighten the currently much modernized drug discovery world and to encourage young generations of scientists working with the traditional Chinese medicines. In order to understand the antimalarial mechanism of artemisinin analogues, we firstly discussed on quantitative structure- activity relationship, structure-based physico-chemical properties, and molecular docking generated putative “bioactive” conformations of artemisinin analogues. In addition to the outstanding antimalarial activity, artemisinin and its derivatives also show significant immunosuppressive effects both in vitro and in vivo . We then summarized some typical artemisinin analogues that exhibit promising therapeutic effects on multiple autoimmune diseases, by suppressing the differentiation and expansion of pathologic T helper cells and accumulation of plasma cells, etc. The unusual endoperoxide and multiple cyclic structure of artemisinin has also been extensively explored to develop analogues with cytotoxic anticancer effects. Unfortunately, most of these artemisinin analogues failed to show tumor growth inhibition in vivo . To overcome this limitation, we finally reviewed some recent progresses to develop molecularly targeted anticancer therapies derived from artemisinin, by combining the typical skeleton of artemisinin or its fragmented intermediates with a molecularly targeted drug bullet. Among several tried approaches, the incorporation of a Smo antagonistic structural motif into the structure of artemisinin led to highly potent Smo-targeting antagonists. The recognition by the Nobel Prize does not mean that the study of artemisinin is over; instead, this great honor will inspire scientists around the world to move on to discover more therapeutic effects of artemisinin compounds, and to explore other potential gifts from Traditional Chinese Medicine.
Archive | 2005
Shen Jianhua; Shen Xu; Jiang Hualiang
Archive | 2005
Jiang Hualiang; Shen Xu; Zuo Jianping
Archive | 2014
Liu Hong; Wang Hui; Jiang Hualiang; Ye Deju; Hao Miao; Chen Tao; Wang Hengshuai; Wang Jinfang; Chen Kaixian
Archive | 2014
Liu Hong; Xie Xin; Guo Diliang; Li Jing; Zhang Yi; Chen Ying; Sun Haifeng; Li Zeng; Jiang Hualiang; Chen Kaixian
Archive | 2014
He Chuan; Wang Jing; Jiang Hualiang; Luo Cheng; Liu Hong; Lu Junyan
Archive | 2012
Liu Hong; Xie Xin; Zhen Xuechu; Sun Haifeng; Li Jing; Zhu Liyuan; Li Zeng; Chen Ying; Jiang Hualiang; Chen Kaixian
Archive | 2017
Jiang Hualiang; Wang Zhen; Li Jianfeng; Zhang Rongxia; He Yang; Liu Yongjian; Bi Minghao; Liu Zheng; Tian Guanghui; Chen Weiming; Yang Feipu; Wu Chunhui; Wang Yu; Jiang Xiangrui; Yin Jingjing; Wang Guan; Shen Jingshan