Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Jiang Jiandong.
药学学报 2017, Vol. 12, Pages 1895-1902 | 2017
曾庆轩; Zeng Qing-xuan; 张娜; Zhang Na; 邓洪斌; Deng Hongbin; 宋丹青; Song Danqing; 蒋建东; Jiang Jiandong; 汪燕翔; Wang Yanxiang
白介素-6（IL-6）/转录激活因子（STAT）信号通路的活化与动脉粥样硬化（AS）的发生发展密切相关。本研究以我国天然产物单体盐酸小檗碱（BBR）为先导物，通过在其3-位或/和9-位引入不同类型的侧链基团，设计合成了一系列全新结构BBR衍生物，并对其抑制IL-6诱导的STAT1/3的磷酸化进行了评价。构效关系表明，3-位或9-位引入刚性结构有利于活性提高，其中，化合物2b和9显示出最优的抑制活性。进一步研究提示，化合物2b和9通过激活HUVEC细胞中AMPK活性，抑制IL-6诱导的STAT1和STAT3磷酸化。研究结果显示，BBR衍生物通过AMPK途径抑制IL-6/STAT信号通路介导的炎症反应，为此类化合物发展成为抗AS候选物提供了有益的科学数据。
Acta pharmaceutica Sinica | 2010
He WeiYing; Gao Rongmei; Li XingQiong; Jiang Jiandong; Li Yuhuan
Archive | 2015
Jiang Jiandong; Li Zhuorong; Li Yanping; Li Yuhuan; Peng Zonggen; Hao Lanhu; Zhong Zhaojin
Archive | 2013
Hao Xiaojiang; Chen Duozhi; Yin Junlin; Peng Zonggen; He Hongping; Jiang Jiandong; Di Yingtong; Zhang Yu; Li ShunLin
Archive | 2015
Jiang Jiandong; Song Danqing; Gao Limei; Li Yuhuan; Gao Rongmei; Wang Huiqiang; Du Nana
Archive | 2015
Song Danqing; Jiang Jiandong; Xiao Chunling; Liu Yanxin; Li Yinghong; Wang Yanxiang; Yang Yanhui
Archive | 2013
Wang Zhen; Wang Yiguang; Chen Jinjing; Kong Weijia; Jiang Jiandong; Si Shuyi; He Qiyang
Archive | 2017
Song Danqing; Jiang Jiandong; Tang Sheng; Kong Weijia; Wang Yanxiang; Wang Can; Li Yinghong; Li Yuhuan; Zhang Jing-Pu
Archive | 2017
Song Danqing; Jiang Jiandong; Peng Zonggen; Zhang Xin; Tang Sheng; Li Yinghong; Li Yuhuan
Archive | 2017
Rao Yu; Lou Zhiyong; Yang Yiqing; Cao Lin; Peng Zonggen; Jiang Jiandong
