Jianxiu Liu
Boehringer Ingelheim
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Publication
Featured researches published by Jianxiu Liu.
Organic Letters | 2013
Xudong Wei; Chutian Shu; Nizar Haddad; Xingzhong Zeng; Nitinchandra D. Patel; Zhulin Tan; Jianxiu Liu; Heewon Lee; Sherry Shen; Scot Campbell; Richard J. Varsolona; Carl A. Busacca; Azad Hossain; Nathan K. Yee; Chris H. Senanayake
A highly convergent large scale synthesis of a 15-membered macrocyclic hepatitis C virus (HCV) protease inhibitor BI 201302 was achieved, in which the key features are the practical macrocyclization by Ru-catalyzed ring-closing metathesis (0.1 mol % Grela catalyst, 0.1-0.2 M concentration) and the efficient sulfone-mediated SNAr reaction.
Organic Letters | 2014
Yongda Zhang; Bruce Z. Lu; Guisheng Li; Sonia Rodriguez; Jonathan Tan; Han-Xun Wei; Jianxiu Liu; Frank Roschangar; Fei Ding; Wenyi Zhao; Bo Qu; Diana C. Reeves; Nelu Grinberg; Heewon Lee; Golo Heckmann; Oliver Niemeier; Michael Brenner; Youla S. Tsantrizos; Pierre L. Beaulieu; Azad Hossain; Nathan K. Yee; Vittorio Farina; Chris H. Senanayake
A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127, 1) was achieved, featuring efficient Pd-catalyzed one-pot borylation-Suzuki coupling where TFP was identified as the unique ligand effective for these transformations.
Organic Letters | 2006
Jianxiu Liu; Ming Shen; Yongda Zhang; Guisheng Li; Khodabocus A; Sonia Rodriguez; Bo Qu; Farina; Chris H. Senanayake; Bruce Z. Lu
Tetrahedron Letters | 2008
Frank Roschangar; Jianxiu Liu; Emilie Estanove; Marine Dufour; Sonia Rodriguez; Vittorio Farina; Eugene R. Hickey; Azad Hossain; Paul-James Jones; Heewon Lee; Bruce Z. Lu; Richard J. Varsolona; Jürgen Schröder; Pierre L. Beaulieu; James Gillard; Chris H. Senanayake
Advanced Synthesis & Catalysis | 2010
Jianxiu Liu; Yongda Zhang; Guisheng Li; Frank Roschangar; Vittorio Farina; Chris H. Senanayake; Bruce Z. Lu
Archive | 2005
Guisheng Li; Jianxiu Liu; Zhi-Hui Lu; Frank Roschangar; Chris H. Senanayake; Ming Shen
Archive | 2006
Guisheng Li; Jianxiu Liu; Zhi-Hui Lu; Ming Shen; Sonia Rodriguez; Vittorio Farina
Archive | 2006
Fabrice Gallou; Carl A. Busacca; Nizar Haddad; Azad Hossain; Suresh R. Kapadia; Jianxiu Liu; Chris H. Senanayake; Xudong Wei; Nathan K. Yee
Archive | 2006
Guisheng Li; Jianxiu Liu; Zhi-Hui Lu; Frank Roschangar; Chris H. Senanayake; Ming Shen
Archive | 2006
Carl A. Busacca; Fabrice Gallou; Nizar Haddad; Azad Hossain; Suresh R. Kapadia; Jianxiu Liu; Chris H. Senanayake; Xudong Wei; Nathan K. Yee
