Jiao Wu

A new cytotoxic homoisoflavonoid from Dracaena cambodiana

A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3′-dihydroxy-4′-methoxy-8-methylflavane (2) and (2R)-7,4′-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9 μg/ml, respectively.

A new cytotoxic 19-nor-cardenolide from the latex of Antiaris toxicaria.

A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.

Two new cytotoxic cardenolides from the latex of Antiaris toxicaria

Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method.

Two new biflavonoids from the stem of Dracaena cambodiana

Phytochemical studies on the stem of Dracaena cambodiana led to the discovery of two new biflavonoids, 8-methylsocotrin-3′-methoxy-4′-ol (1) and 8-methylsocotrin-4′-methoxy-3′-ol (2), together with a known biflavonoid, 8-methylsocotrin-4′-ol (3). Their structures were identified by means of HR-ESI-MS and detailed spectral analysis (UV, IR, and 1D and 2D NMR).

Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis.

Three new C-methylated acetogenins, (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene (1), (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene (2), and (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene (3), together with two known compounds, p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (IR, UV, 1D, and 2D NMR). Compound 5 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.

Flavonoids from Dracaena cambodiana

0009-3130/11/4704-0624 2011 Springer Science+Business Media, Inc. Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, P. R. China, fax: 86 898 66988061, e-mail: hfdai2001@yahoo.com.cn; meiwenli@yahoo.com.cn. Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 551–552, July–August, 2011. Original article submitted April 22, 2010. Chemistry of Natural Compounds, Vol. 47, No. 4, September, 2011 [Russian original No. 4, July–August, 2011]

Flavanes from Dracaena cambodiana

Two new flavanes, (2S)-4′ ,7-dihydroxy-6,8-dimethylflavane (1), and (2S)-5,7-dihydroxy-4′-methoxy- 8-methylflavane (2), together with five known flavanes, (2S)-3′ ,7-dihydroxy-4′-methoxy-8- methylflavane (3), (2R)-4′,7-dihydroxy-8-methylflavane (4), (±)-3′,7-dihydroxy-4′-methoxyflavane (5), (±)-4′,7-dihydroxy-3′-methoxyflavane (6), and (2S)-4′,7-dihydroxyflavane (7), were isolated from the stem of Dracaena cambodiana. Their structures were determined by spectroscopic techniques (UV, IR, 1D and 2D NMR). Their antimicrobial activities were preliminarily examined by the filter paper disc agar diffusion method.

High-level 1,8-cineole in the Alpinia officinarum essential oil from Hainan Island of China

0009-3130/12/4802-0325 2012 Springer Science+Business Media, Inc. Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropic Bioscience and Biotechnology, Chinese Academy of Tropic Agricultural Sciences, Haikou 571101, P. R. China, fax: +86 10 66890978, e-mail: mmpeng_2000@yahoo.com; hfdai2001@yahoo.com.cn. Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2012, pp. 291–292. Original article submitted December 29, 2010. Chemistry of Natural Compounds, Vol. 48, No. 2, May, 2012 [Russian original No. 2, March–April, 2012]