Jihoon Kweon

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

Since the first observation of a helical flow pattern in aortic blood flow, the existence of helical blood flow has been found to be associated with various pathological conditions such as bicuspid aortic valve, aortic stenosis, and aortic dilatation. However, an understanding of the development of helical blood flow and its clinical implications are still lacking. In our present study, we hypothesized that the direction and angle of aortic inflow can influence helical flow patterns and related hemodynamic features in the thoracic aorta. Therefore, we investigated the hemodynamic features in the thoracic aorta and various aortic inflow angles using patient-specific vascular phantoms that were generated using a 3D printer and time-resolved, 3D, phase-contrast magnetic resonance imaging (PC-MRI). The results show that the rotational direction and strength of helical blood flow in the thoracic aorta largely vary according to the inflow direction of the aorta, and a higher helical velocity results in higher wall shear stress distributions. In addition, right-handed rotational flow conditions with higher rotational velocities imply a larger total kinetic energy than left-handed rotational flow conditions with lower rotational velocities.

Illustration of Wing Deformation Effects in Three-Dimensional Flapping Flight

This study numerically investigates the aerodynamic effects of deformation on three-dimensional low aspect ratio wings engaged in hover kinematics. The immersed-boundary finite-volume method is used to solve the Navier–Stokes equations. Deformations are actively prescribed and are represented as deflections about axes that transect the rectangular planform. Two distinct deformation modes associated with tip and root deflection are explored, in addition to a rigid wing counterpart. Variation of the phase between deflection and flapping enables mimicry of a range of wing behavior observed in nature. It is found the introduction of root or tip deflection can increase efficiency by as much as 19.5% or 19.0% respectively. The development of vortical structures about the wing is investigated. It is shown that while the rotational axis of the leading-edge vortex is insensitive to deformation, the shape and orientation of cores of the vortex is modified.

Effect of pannus formation on the prosthetic heart valve: In vitro demonstration using particle image velocimetry

Although hemodynamic influence of the subprosthetic tissue, termed as pannus, may contribute to prosthetic aortic valve dysfunction, the relationship between pannus extent and hemodynamics in the prosthetic valve has rarely been reported. We investigated the fluid dynamics of pannus formation using in vitro experiments with particle image velocimetry. Subvalvular pannus formation caused substantial changes in prosthetic valve transvalvular peak velocity, transvalvular pressure gradient (TPG) and opening angle. Maximum flow velocity and corresponding TPG were mostly affected by pannus width. When the pannus width was 25% of the valve diameter, pannus formation elevated TPG to >2.5 times higher than that without pannus formation. Opening dysfunction was observed only for a pannus involvement angle of 360°. Although circumferential pannus with an involvement angle of 360° decreased the opening angle of the valve from approximately 82° to 58°, eccentric pannus with an involvement angle of 180° did not induce valve opening dysfunction. The pannus involvement angle largely influenced the velocity flow field at the aortic sinus and corresponding hemodynamic indices, including wall shear stress, principal shear stress and viscous energy loss distributions. Substantial discrepancy between the velocity-based TPG estimation and direct pressure measurements was observed for prosthetic valve flow with pannus formation.