Jill Mauldin

Antenatal factors associated with significant birth weight discordancy in twin gestations.

OBJECTIVE The purpose of this study was to evaluate factors that are associated with significant birth weight discordancy. STUDY DESIGN As a part of an ongoing collaborative study of twins, maternal and fetal data were obtained from the medical records of twin gestations at eight medical centers. The study population was divided into groups by difference in birth weight discordancy (>or=20%, >or=25%, and >or=30%) RESULTS Severe birth weight discordancy was associated with fetal growth deceleration by 20 to 28 weeks (adjusted odds ratio, 4.90; 95% CI, 3.15-7.64) and between 28 weeks to birth (adjusted odds ratio, 3.48; 95% CI, 1.72-7.06). Antenatal bleeding (adjusted odds ratio, 1.86; 95% CI, 1.08-3.21), preeclampsia (adjusted odds ratio, 1.70, 95% CI, 1.21-2.41), and monochorionicity (adjusted odds ratio, 2.35, 95% CI, 11.71-3.23) were also associated with birth weight discordancy. CONCLUSION These data demonstrate the importance of the early diagnosis of placental chorionicity, because monochorionicity is associated with a 2-fold increase in birth weight discordancy in twin gestations.

Determining the clinical efficacy and cost savings of successful external cephalic version.

OBJECTIVE The aim of this study was to determine predictors of successful external cephalic version and to calculate the associated cost savings achieved with success. STUDY DESIGN A retrospective study of 203 women with singleton gestations who underwent external cephalic version was performed. Descriptive, univariate, and multivariate analyses were performed on patient-specific risk data to predict successful version. National claims data were used for the cost simulation. RESULTS Higher parity (p = 0.02), transverse-oblique presentation (p = 0.001), posterior placenta (p = 0.001), and a longer duration of pregnancy (p = 0.001) significantly increased the likelihood of a successful version. Heavier maternal weight was negatively associated with successful version (p = 0.05). The cost simulation revealed an average savings of

Sonographic prediction of twin birth weight discordance

2462 for each successful version. CONCLUSION This study identifies clinical variables associated with an increased external cephalic version success rate. If, in fact, successful external cephalic version reduces both maternal and fetal morbidity associated with cesarean delivery and, as demonstrated in this analysis, the costs associated with the delivery, then greater effort should be made to maximize the success rate of external cephalic version.

Cost-effective delivery management of the vertex and nonvertex twin gestation

Objective To assess the accuracy of sonographic prediction of clinically significant twin birth weight discordance (25% or greater) and to determine whether this accuracy is affected by defined fetal and maternal variables. Methods Using an established database, we reviewed 338 twin gestations delivered over 10 years as a retrospective cohort. Estimation of fetal weight was calculated by applying the Hadlock formula using composite fetal biometry. Intertwin weight discordance was calculated as the difference in the estimated or actual twin weights (A–B) divided by the weight of the larger twin and was expressed as a percentage. Statistical evaluation included validity (sensitivity, specificity, and predictive values) and reliability assessment of ultrasonographic measurements (intraclass correlation coefficients). Multivariable analysis was performed. Results Of 338 twin gestations, 192 (57%) twin pairs met inclusion criteria. Sonographic prediction of actual intertwin birth weight discordance of 25% or greater had a sensitivity of 55%, specificity of 97%, positive predictive value of 82%, and negative predictive value of 91%. The reliability of estimating intertwin birth weight discordance by ultrasonography was moderately high (intraclass correlation coefficient = .700; 95% confidence interval [CI] .620, .765). Multivariable analysis revealed no significant effects of individual maternal or fetal factors on the accuracy of ultrasonographic prediction of intertwin birth weight discordance. Conclusion Sonographic prediction of actual intertwin birth weight discordance of 25% or greater within 16 days of delivery appears to be a valid and reliable method for clinical use. Predictive accuracy is independent of other identifiable maternal or fetal variables.

Quantifying the Impact of Gestational Diabetes Mellitus, Maternal Weight and Race on Birthweight via Quantile Regression

OBJECTIVE The aim of the study was to determine the most cost-effective delivery management of vertex and nonvertex twin pair gestations. STUDY DESIGN Two hundred sixty-six consecutive twin gestations were followed up prospectively in a special antepartum Twins Clinic directed by the Maternal-Fetal Medicine Division. Maternal demographic, obstetric, and neonatal data were compiled prospectively. Information regarding 84 vertex and nonvertex twin pair gestations was extracted for review. Comparison groups included 41 twin pairs managed by spontaneous vaginal delivery and breech extraction (group A), 19 twin pairs managed by spontaneous vaginal delivery and external cephalic version (group B), and 24 twin pairs managed by primary cesarean delivery (group C). In-hospital financial data were retrieved and adjusted for inflation to 1996 constant dollars (data from a single institution allow comparison of charges). The Kruskal-Wallis chi2 test, the Fisher exact test, and analysis of variance were used for statistical analysis. RESULTS The 3 groups did not differ with respect to maternal demographics, medical complications, gestational age, birth weight, fetal sex, or intrauterine growth restriction. Maternal and neonatal hospital charges were both significantly lower (P = .01 and P = .0001, respectively) in the breech extraction group A (

Determining cost savings from attempted cephalic version in an inner city delivering population

5890 +/-

Risk factors for neonatal death in twin gestations in the state of South Carolina

2304 and

Prior cesarean: a contraindication to labor induction?

3526 +/-

Domperidone for Treatment of Low Milk Supply in Breast Pump-Dependent Mothers of Hospitalized Premature Infants: A Clinical Protocol.

5017, respectively) than in either group B (

Predictors of Emergent Outcome in Preterm Premature Rupture of Membranes

8638 +/-