Jin-soo Seo

Solid phase synthesis of biphenyltetrazole derivatives

Abstract A dihydropyran carboxylic acid type linker is suitable for the solid phase Suzuki type aryl-aryl coupling reaction for the preparation of various biphenyltetrazole derivatives.

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-zeta inhibitors.

A new vinyl ether type linker for solid-phase synthesis

Abstract A new vinyl ether type of linker based on 4-hydroxy phenethyl alcohol is developed for the solid-phase synthesis as demonstrated in the Suzuki type of aryl–aryl coupling reaction for the preparation of various biphenyl tetrazole derivatives.