Jin-Tian Ma
Central China Normal University
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Publication
Featured researches published by Jin-Tian Ma.
Journal of Organic Chemistry | 2016
Qun Cai; Deng-Kui Li; Rong-Rong Zhou; Shiyi Zhuang; Jin-Tian Ma; Yan-Dong Wu; An-Xin Wu
An acid-catalyzed multicomponent tandem double cyclization protocol has been developed for the synthesis of polyfunctional 4,9-dihydropyrrolo[2,1-b]quinazolines from simple and readily available arylglyoxal monohydrates, 2-aminobenzylamine, and trans-β-nitrostyrenes. This practical and metal-free reaction proceeds through an imine formation/cyclization/Michael addition/Henry cyclization protocol, resulting in the construction of four new bonds and two ring moieties directly in one pot.
Organic Letters | 2017
Jia-Chen Xiang; Yan Cheng; Zi-Xuan Wang; Jin-Tian Ma; Miao Wang; Bo-Cheng Tang; Yan-Dong Wu; An-Xin Wu
An oxidative trimerization of three amino acids has been realized to furnish 2,3,5-trisubstuitued pyridines in both cross- and homo-trimerization types. This method is capable of converting simple linear biomass material to heterocycles, which features in the assembly of three amino acid branched chains into one aromatic ring. Molecular iodine triggers the sequential decarboxylation and deamination of amino acids and then promotes the selective formation of new C-N and C-C bonds.
Journal of Organic Chemistry | 2018
Miao Wang; Bo-Cheng Tang; Jia-Chen Xiang; Yan Cheng; Zi-Xuan Wang; Jin-Tian Ma; Yan-Dong Wu; An-Xin Wu
An efficient base-promoted C(sp3)-H bond functionalization strategy for the synthesis of multisubstituted chromans from the formal [3+3] cycloaddition of benzo[ c]oxepines and electron-rich phenols has been developed. The corresponding 4 H-chromenes can be easily obtained in excellent yields by simple filtration from chromans. Preliminary mechanistic studies indicate that the C-O bond cleavage is the key step for the C(sp3)-H bond functionalization and that this reaction could have occurred through tandem C-O bond cleavage/Michael addition/annulation reactions.
Journal of Organic Chemistry | 2017
Jia-Chen Xiang; Zi-Xuan Wang; Yan Cheng; Jin-Tian Ma; Miao Wang; Bo-Cheng Tang; Yan-Dong Wu; An-Xin Wu
An expeditious one-step synthesis of the imidazopyridoindole scaffold was achieved through the C-H oxidation/two-fold cyclization reaction of methyl ketone and tryptamine derivatives. Mild oxidizing conditions were employed to realize the efficient oxidation of C(sp3)-H bonds, while suppressing overoxidation of the intermediate and ensuring the cross-trapping of two in situ generated acylimine intermediates.
Organic Letters | 2018
Zi-Xuan Wang; Jia-Chen Xiang; Miao Wang; Jin-Tian Ma; Yan-Dong Wu; An-Xin Wu
The one-pot total synthesis of evodiamine and its analogues is achieved using a three-component reaction. Through continuous biscyclization, various readily available substrates with good functional group tolerance were easily incorporated into biologically active quinazolinocarboline backbones. The use of triethoxymethane as a cosolvent was crucial for this quick and straightforward transformation.
Journal of Organic Chemistry | 2018
Zi-Xuan Wang; Jia-Chen Xiang; Yan Cheng; Jin-Tian Ma; Yan-Dong Wu; An-Xin Wu
The increasing importance of enzyme mimics in organic synthesis inspired us to design a novel biomimetic synthesis of β-carboline alkaloids directly from tryptophan and a second amino acid. This novel one-pot protocol utilizes abundant and readily available starting materials and thus presents a green and user-friendly alternative to conventional methods that rely on stepwise synthesis. Driven by molecular iodine and TFA, decarboxylation, deamination, Pictet-Spengler reaction, and oxidation reactions proceeded sequentially, transforming biomass amino acids into value-added alkaloid motifs.
Archive | 2017
Jia-Chen Xiang; Yan Cheng; Zi-Xuan Wang; Jin-Tian Ma; Miao Wang; Bo-Cheng Tang; Yan-Dong Wu; An-Xin Wu
Related Article: Jia-Chen Xiang, Yan Cheng, Zi-Xuan Wang, Jin-Tian Ma, Miao Wang, Bo-Cheng Tang, Yan-Dong Wu, and An-Xin Wu|2017|Org.Lett.|19|2997|doi:10.1021/acs.orglett.7b01232
Archive | 2017
Jia-Chen Xiang; Yan Cheng; Zi-Xuan Wang; Jin-Tian Ma; Miao Wang; Bo-Cheng Tang; Yan-Dong Wu; An-Xin Wu
Related Article: Jia-Chen Xiang, Yan Cheng, Zi-Xuan Wang, Jin-Tian Ma, Miao Wang, Bo-Cheng Tang, Yan-Dong Wu, and An-Xin Wu|2017|Org.Lett.|19|2997|doi:10.1021/acs.orglett.7b01232
Advanced Synthesis & Catalysis | 2018
Yan Cheng; Jia-Chen Xiang; Zi-Xuan Wang; Jin-Tian Ma; Miao Wang; Bo-Cheng Tang; Yan-Dong Wu; Yan-Ping Zhu; An-Xin Wu
Advanced Synthesis & Catalysis | 2018
Bo-Cheng Tang; Miao Wang; Jin-Tian Ma; Zi-Xuan Wang; Yan-Dong Wu; An-Xin Wu