Jin-Ting Liu

Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives.

A series of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives was synthesized and characterized by 1H NMR, 13C NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest.

Novel pyrazoline-based selective fluorescent probe for the detection of hydrazine

A novel pyrazoline-based fluorescent probe, 2-[4-(3,5-diphenyl-4,5-dihydro-pyrazol-1-yl)-benzylidene]-malononitrile, with a simple structure and low detection limit (6.16×10(-6)M) for the detection of hydrazine is designed and synthesized. The probe responds selectively to hydrazine over other molecules with marked fluorescence enhancement. The probe can detect hydrazine effectively at pH 5.0-9.0 with a special emission wavelength at 520nm. Moreover, the probe can be used to detect hydrazine from variety of natural source water.

A new Schiff base fluorescent probe for imaging Cu2+ in living cells

A novel probe based on ferrocenyl-1,3,4-thiadiazol-containing Schiff base was synthesized by the reaction of 5-ferrocenyl-1,3,4-thiadiazol-2-amine and 4-(diethylamino)salicylaldehyde, and characterized by IR, NMR, HRMS and X-ray analysis. UV-vis spectral and fluorescence property of the probe were investigated. The probe can be used to colorimetric sensitive and selective fluorescent recognition of Cu(2+) in buffer solution. Moreover, the probe can detect Cu(2+) by electrochemical method. Additionally, the Schiff base was successfully used as a selective and sensitive fluorescent probe for monitoring Cu(2+) ions in living cells.

A dansyl based fluorescence chemosensor for Hg2+ and its application in the complicated environment samples

We have developed a novel fluorescent chemosensor (DAM) based on dansyl and morpholine units for the detection of mercury ion with excellent selectivity and sensitivity. In the presence of Hg(2+) in a mixture solution of HEPES buffer (pH 7.5, 20 mM) and MeCN (2/8, v/v) at room temperature, the fluorescence of DAM was almost completely quenched from green to colorless with fast response time. Moreover, DAM also showed its excellent anti-interference capability even in the presence of large amount of interfering ions. It is worth noting that DAM could be used to detect Hg(2+) specifically in the Yellow River samples, which significantly implied the potential applications of DAM in the complicated environment samples.

Synthesis, X-ray crystal structure and optical properties of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole.

A series of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole derivatives has been synthesized from 6-methoxy-3-methylbenzofuran-2-carboxylic acid and ethyl 3-aryl-1H-pyrazole-5-carboxylate. The structures of compounds obtained were determined by IR, (1)H NMR and HRMS spectra. Typically, the spatial structure of compound 7e was determined by using X-ray diffraction analysis. UV-vis absorption and fluorescence spectral characteristics of the compounds in dichloromethane and acetonitrile were investigated. The results showed that the absorption maxima of the compounds vary from 321 to 339 nm depending on the substituents in N-1 position of pyrazole moiety and para position of benzene moiety. The maximum emission spectra of compounds in two different solvents were mainly dependent on groups in N-1 position of pyrazole moiety. The intensity of absorption and fluorescence was also correlated with substituents on the aryl ring bonded to pyrazole moiety. In addition, the absorption and emission spectra of these compounds change with increasing solvent polarity.

Synthesis of novel boron chelate complexes and proposed mechanism of new rearrangement.

We synthesized novel boron chelate complexes by the reaction of pyrazoline derivatives and boron trifluoride diethyl etherate followed by a new rearrangement. The structures of the compounds were characterized by IR, NMR and HRMS, especially, a typical compound 3c was confirmed by X-ray single crystal analysis. We proposed a mechanism of the rearrangement. Moreover, the absorption and fluorescence spectroscopy of these compounds were measured.

Synthesis, Structure Characterization, and X-ray Crystallography of Novel 1-Benzyl-3-phenyl-1H-pyrazole-5-carboxylate Derivatives with a Carbohydrate Moiety

A series of novel (2S,3R,4S,5R)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-yl 1-benzyl-3-phenyl-1H-pyrazole-5-carboxylate derivatives (3) were synthesized by the reaction of 2,3,4-tri-O-acetyl-α-D-xylopyranosyl bromide (2) and 1-benzyl-3-phenyl-1H-pyrazole-5-carboxylic acid (1) in the presence of sodium bicarbonate and tetrabutylammonium bromide in dichloromethane at reflux temperature. The structures of new compounds were determined by IR and 1H NMR spectroscopy and HR mass spectrometry (HRMS), and the configuration of the newly generated chiral carbon (C-1) in the xylose ring was tentatively assigned based on the X-ray crystallographic structure of 3d and 3g.

Energy-efficient cooperative routing algorithm with truncated automatic repeat request over Nakagami-m fading channels

Based on the selection decode-and-forward cooperative protocol, a novel distributed quality of service (QoS) aware routing algorithm is proposed to minimise the total energy consumption of the wireless links from the cross-layer design perspective. For the non-cooperative and cooperative truncated automatic repeat request schemes, performance of packet error rate with M-PSK and M-QAM symbols over Nakagami-m fading channels is first analysed, and then system throughput is derived. Subsequently, transmission power is optimally allocated while satisfying the end-to-end throughput requirement. With polynomial complexity, using the traditional distributed shortest path algorithm, the route that includes a cascade of non-cooperative and cooperative building blocks and has the minimal total link cost (defined as the average total consumed power) is constructed to bear the information flow. In contrast to the previous non-cooperative routing schemes, this cooperative routing algorithm can significantly reduce the total energy consumption.