Jinesh Patel
Cleveland Clinic
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Publication
Featured researches published by Jinesh Patel.
Surgery | 2016
Altay Aliyev; Jinesh Patel; Jennifer Brainard; Manjula K. Gupta; Christian Nasr; Betul Hatipoglu; Allan Siperstein; Eren Berber
BACKGROUND The aim of this study was to analyze the usefulness of thyrotropin receptor messenger RNA (TSHR-mRNA) combined with neck ultrasonography (US) in the management of thyroid nodules with Bethesda III-V cytology. METHODS Cytology slides of patients with a preoperative fine needle aspiration (FNA) and TSHR-mRNA who underwent thyroidectomy between 2002 and 2011 were recategorized based on the Bethesda classification. Results of thyroid FNA, TSHR-mRNA, and US were compared with the final pathology. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. RESULTS There were 12 patients with Bethesda III, 112 with Bethesda IV, and 58 with Bethesda V cytology. The sensitivity of TSHR-mRNA in predicting cancer was 33%, 65%, and 79 %, and specificity was 67%, 66%, and 71%, for Bethesda III, IV, and V categories, respectively. For the same categories, the PPV of TSHR-mRNA was 25%, 33%, and 79%, respectively; whereas the NPV was 75%, 88%, and 71%, respectively. The addition of neck US to TSHR-mRNA increased the NPV to 100% for Bethesda III, and 86%, for Bethesda IV, and 82% for Bethesda V disease. CONCLUSION This study documents the potential usefulness of TSHR-mRNA for thyroid nodules with Bethesda III-V FNA categories. TSHR-mRNA may be used to exclude Bethesda IV disease. A large sample analysis is needed to determine its accuracy for Bethesda category III nodules.
Cancer Cytopathology | 2016
Abha Goyal; Fadi W. Abdul-Karim; Bin Yang; Jinesh Patel; Jennifer Brainard
The accurate cytologic grading of epithelial atypia in fine‐needle aspirates of pancreatic mucinous cysts has important implications for clinical management. The Papanicolaou Society of Cytopathology has recommended a 2‐tiered system of low‐grade (LG) and high‐grade (HG) for grading this atypia. Using this approach, this study examined the interobserver agreement within a group of cytopathologists at the Cleveland Clinic.
Annals of the American Thoracic Society | 2016
Haala K. Rokadia; Atul C. Mehta; Daniel A. Culver; Jinesh Patel; Michael Machuzak; Francisco Almeida; Thomas R. Gildea; Sonali Sethi; Katrina Zell; Joseph Cicenia
RATIONALE Rapid On-Site Evaluation (ROSE) of specimens collected by endobronchial ultrasound (EBUS)-guided-transbronchial needle aspiration (TBNA) ensures sample adequacy and triages subsequent biopsy procedures. EBUS-TBNA allows sampling of lymph nodes in granulomatous diseases; however, the ability of ROSE to predict the final diagnosis in this setting has not been well characterized. OBJECTIVES We performed a retrospective evaluation to study the utility of ROSE in the diagnosis of granulomatous diseases as well as to establish the procedure characteristics that would optimize the concordance between ROSE and final diagnosis. METHODS Charts of patients with a cytological diagnosis of granuloma by EBUS-TBNA between June 2008 and May 2013 were reviewed. Preliminary ROSE findings and final cytological diagnosis were compared. Patient demographics and procedure variables were assessed using mean (±SD). The variables collected were considered in a logistic regression analysis using concordance as the outcome. MEASUREMENTS AND MAIN RESULTS In our study, 255 procedures were performed to sample 625 lymph nodes that contained granulomas. An average of 2.4 (±1.2) lymph nodes were biopsied per procedure, with a mean size of 14.4 (±7.9) mm. The concordance between ROSE and the final diagnosis was 81.6%. The concordance rate was not impacted by needle size, lymph nodes size or station, number of stations biopsied, or passes per lymph node. The concordance did improve with the experience of the bronchoscopist (P < 0001). CONCLUSIONS In this single-center study, there was a high concordance between ROSE and the final cytological diagnosis for mediastinal lymph nodes containing granulomas that were sampled by EBUS-TBNA. ROSE may serve to reduce procedure time, enhance sample triaging, and obviate the need for further invasive testing. The only variable associated with increased concordance was the experience of the operator.
Journal of Clinical Oncology | 2016
Gauri Bhuchar; Soamsiri Niwattisaiwong; Rushad Patell; Jinesh Patel; Eren Berber; Michael Tabet; T. Nwizu; Christian Nasr
Journal of the American Society of Cytopathology | 2016
Jinesh Patel; Juan Xing; David Deeds; G. Thomas Budd; Christine N. Booth; Fadi W. Abdul-Karim
Annals of the American Thoracic Society | 2016
Haala Rokadia; Atul C. Mehta; Daniel A. Culver; Jinesh Patel; Michael Machuzak; Francisco Almeida; Thomas R. Gildea; Sonali Sethi; Katrina Zell; Joseph Cicenia
Chest | 2014
Wissam Jaber; Danai Khemasuwan; Jinesh Patel; Abdul Hamid Alraiyes; Joseph Cicenia; Thomas R. Gildea; Abha Goyal; Micheal Machuzak; Atul C. Mehta; Sonali Sethi; Francisco Almeida
Journal of the American Society of Cytopathology | 2013
Jinesh Patel; Dawn Underwood; Julie Shorie; Jennifer Brainard
Chest | 2013
Sonali Sethi; Michael Machuzak; Francisco Almeida; Thomas R. Gildea; Peter J. Mazzone; Atul C. Mehta; Jinesh Patel; Joseph Cicenia
Journal of the American Society of Cytopathology | 2012
Jinesh Patel; Abha Goyal