Jing-Fu Liu

Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7− (Cp=η5-C5H5)

A novel polyoxotungstate [CoW(11)O(39)(CpTi)](7-) (Cp=eta(5)-C(5)H(5)) has been prepared. This complex exhibits the highest antitumor activity in vitro among the cyclopentadienyltitanium substituted polyoxometalates investigated and has a remarkable inhibitory action on three types of human cancer cells, SSMC-7721, HL-60 and HLC, in vivo.

Two new coordination polymers of Co(II) with 1,1'-(1,4-butanediyl)bis(benzimidazole)

Two new compounds, [CoL2(H2O)2](NO3)2·8H2O (1) and [CoL(H2O)2(CH3CO2)2]·H2O (2), were obtained from self-assembly of the corresponding metal salts with 1,1′-(1,4-butanediyl)bis(benzimidazole) (L). In 1, each cobalt ion is coordinated to four nitrogen atoms from four molecules of L, and to two water molecules. Metal ions are bridged by L ligands to form infinite (4, 4) networks that contain 44-membered rings. The (4, 4) networks of 1 stack in a parallel fashion, resulting in the formation of large channels in the material. In 2, each cobalt ion is coordinated to two N atoms from two L molecules, two water molecules and two carboxylate O atoms from two acetate anions. Each L molecule is coordinated to two cobalt ions, acting as a bridging ligand as in 1. The bridged cobalt ions form an infinite zigzag chain structure.

Synthesis, characterization and in vitro antitumor activity of diorganometallo complexes γ-Keggin anions

Abstract Diorganometallo-substituted γ-Keggin heteropolytungstates γ-[(RSn)2SiW10O38]6−[R=MeOCOCH2CH2, MeOCOCH(Me)CH2,NCCH2CH2], γ-[(CpTi)2SiW10O38]6− and γ-[(CpZr)2SiW10O38]6− have been prepared from the divacant polyanion γ-SiW10O368− and their structures have been determined by NMR spectroscopy. The 183 W NMR spectra of complexes show three peaks, indicating that these anions have the anticipated γ-Keggin structure with C2V symmetry. The title complexes exhibit antitumor activity in vitro.

Networks with hexagonal circuits in co-ordination polymers of metal ions (ZnII, CdII) with 1,1′-(1,4-butanediyl)bis(imidazole)

Three new compounds, [ZnL1.5(H2O)(SO4)]·6H2O 1, [ZnL1.5(H2O)2][NO3]2·2H2O 2 and [CdL1.5(H2O)2(SO4)]·4H2O 3 were obtained from self-assembly of the corresponding metal salts with 1,1′-(1,4-butanediyl)bis(imidazole) (L). In both 1 and 2 zinc ion is five-co-ordinated, showing a less-common trigonal bipyramidal co-ordination polyhedron, while cadmium ion of 3 is six-co-ordinated with a common octahedral arrangement. The sulfate ions of 1 and 3 are co-ordinated, however the nitrate ions of 2 are not. Each of the three compounds is composed of a (6, 3) network with the hexagonal smallest circuit containing six metal ions and six L; each L is co-ordinated to two metal ions, acting as a bridging ligand. In 1 the 2-D sheet of (6, 3) networks is interpenetrated in an inclined mode by symmetry related, identical sheets to give an interlocked 3-D structure, while the (6, 3) networks of both 2 and 3 stack in a parallel fashion to construct frameworks having channels.

Synthesis and characterization of novel heteropoly-tungstoarsenates containing lanthanides [LnAs4W40O140]25− and their biological activity

Abstract A series of lanthanide polyoxoanions [LnAs4W40O140]25− (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy or Yb) have been prepared from the cryptate anion [NaAs4W40O140]27− and lanthanides and characterized by elemental analysis, 183W NMR, emission spectra. A number of evidences indicate that the lanthanides occupy the central site in the complexes. The title complexes display anti-tumor activity in vitro and in vivo.

The first ladder structure containing three different squares: the structure of barium 3-carboxy-4-hydroxybenzenesulfonate

Abstract Barium sulfonate [Ba2L4(H2O)10] (HL=3-carboxy-4-hydroxybenzenesulfonic acid) was obtained by the reaction of BaCl2·2H2O with NaL in water. X-ray structural analysis reveals that the compound has an undulating ladder structure which is the first ladder structure containing three different kinds of squares.

Synthesis of isomers of organotin substituted polyoxotungstates and comparison of the antitumor activity of isomers

A comparison of the antitumor activity against two human tumor cell lines for the isomers of organometallo-substituted polyoxometalates is reported. The polyoxometalate skeletal isomers affect the antitumor activity. It is observed that the order of the antitumor activity of complexes is consistent with the order of the oxidation ability of polyanions among a couple of isomers possessing the same polyanion and organometallic group whether in the series of monosubstituted complexes or trisubstituted complexes as well in the sandwich compounds.

Syntheses, crystal structures and characterization of divalent transition metal sulfonate complexes with o-phenanthroline

Abstract Three new complexes, namely [Cu(phen)(L)(H2O)2]L·H2O 1, [M(phen)2(H2O)2]2L·6H2O [M=Co(2), Ni(3)], where, HL=4-methylbenzenesulfonic acid and phen=o-phenanthroline, have been synthesized. The crystal structures were determined by X-ray diffraction method and refined by full-matrix least-squares methods to R=0.0535 and wR=0.1492 using 3567 reflections with I>2σ(I) for 1; R=0.0388 and wR=0.1223 using 3844 reflections with I>2σ(I) for 2; and R=0.0401 and wR=0.1222 using 3425 reflections with I>2σ(I) for 3. 1 Consists of cationic species [Cu(phen)(L)(H2O)2]+, in which Cu(II) ion is five-coordinated by two nitrogen atoms of o-phenanthroline, two water molecules and one sulfonate oxygen atom. The cations and the non-coordinating sulfonate anions are linked by hydrogen bonds to form infinite chains. Complexes 2 and 3 are isostructral compounds. Each of them consists of cationic species [M(phen)2(H2O)2]2+, in which metal ion is six-coordinated by four nitrogen atoms from two o-phenanthroline molecules and two water oxygen atoms. The sulfonate ions do not coordinate to metal ion. The cations, non-coordinating sulfonate ions and lattice water molecules are linked by hydrogen bonds to form infinite zigzag chains. CV, FT-IR, UV–Vis and TGA were also used to characterize these compounds.

Synthesis and spectroscopic characterization of organophosphoryl polyoxotungstates [C6H11P(O)]2Xn+W11O39(8−n)− (Xn+=P5+, Si4+, B3+, Ga3+)

Abstract In the presence of NBu 4 Br acting as a phase-transfer reagent, the monovalent polyoxotungstates α-X n + W 11 O 39 (12− n )− (X=P, Si, B, Ga) react with electrophilic cyclohexane phosphonyl chloride to give hybrid organophosphoryl polyoxotungstates [(C 6 H 11 P(O)] 2 XW 11 O 39 (8− n )− , which have been characterized by elemental analysis and IR, 31 P and 183 W NMR spectroscopy. The six-line 183 W spectra indicate that the hybrid anions possess C s symmetry in solution. According to spectroscopic observations and chemical analyses, the hybrid anion consists of an α-[XW 11 O 39 ] framework on which are grafted two equivalent C 6 H 5 P(O) groups through P–O–W bridges.

Synthesis and characterization of organophosphorylpolyoxotungstate [α2-R2P2W17O61]6−(R=C6H11P(O), C6H5P(O), C6H11P(S), C6H5P(S))

Abstract In the presence of Bu n 4 NBr acting as a phase-transfer reagent, organophosphoryl derivatives of tungstophosphate of formula [ α 2 -R 2 P 2 W 17 O 61 ] 6− (R=C 6 H 11 P(O) ( 1 ); C 6 H 5 P(O) ( 2 ); C 6 H 11 P(S) ( 3 ); C 6 H 5 P(S) ( 4 )) have been prepared and characterized by elemental analysis, IR, 31 P and 183 W NMR spectroscopy. The nine-line 183 W spectrum indicates the hybrid anion possesses C s symmetry in CH 3 CN–CD 3 CN.