Jing-Ping Liu

Schinalactone A, a New Cytotoxic Triterpenoid from Schisandra sphenanthera

A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.

Propinic lactones A and B, two new triterpenoids from Schisandra propinqua var. propinqua and the significance in biosythesis pathway.

Abstract Aim To study the chemical constituents of the aerial parts of Schisandra propinqua var. propinqua . Method Silica gel, C 18 reversed phase silica gel and HPLC were used. The structures were elucidated by extensive spectroscopic methods. Result Two new triterpenoids, propinic lactone A ( 1 ) with 3, 4- seco -cycloartane skeleton, and propinic lactone B ( 2 ) possessing 3, 4:9, 10- seco -cycloartane skeleton, together with a known typical cycloartane triterpenoid, schizandronic acid ( 3 ), have been isolated and identified. Conclusion These two new triterpenoids serve as two important bridge intermediates from cycloartane triterpenoids to Schisandra nortriterpenoids biogenetically.

Five New Diarylpropan-1-ols from Combretum yunnanense

Five new 1,3-diarylpropan-1-ols, combretol A-E (1- 5), together with one known coumarin (6) and ten known triterpenes (7-16), were isolated from Combretum yunnanense. Their structures were determined by spectroscopic investigation, including ¹H and ¹³C NMR, NOESY, HSQC, HMBC, and HRESIMS analyses. This is the first report on the occurrence of 1,3-diarylpropan-1-ols and coumarin in the Combretum genus including C. yunnanense. Also, to the best of our knowledge, 1,3-diarylpropan-1-ols are rare in nature.