Jing Ru

Triorganotin(IV) complexes with substituted benzeneseleninic acids: syntheses, characterization, crystal structures, and antitumor activity

Nine new organotin(IV) selenites have been prepared by the reaction of 2-methylbenzeneseleninic acid, 2-methoxybenzeneseleninic acid, 4-isopropylbenzeneseleninic acid, and the corresponding triorganotin(IV) chloride with sodium ethoxide in methanol. The complexes have been characterized by elemental analysis, FT-IR, (1H, 13C, and 119Sn) NMR spectroscopy, and thermogravimetric analysis. Except for 3, 6, and 9, all of the complexes were also characterized by X-ray crystallography diffraction analyses. The structural analyses reveal that 1, 2, 4, 5, 7, and 8 exhibit 1-D infinite chain structures which are generated by bidentate oxygen atoms and five-coordinated tin. Complex 5 forms a 2-D organotin framework linked by intermolecular C–H ··· O interactions. Additionally, 1 and 2 were tested for antitumor activity in vitro.

Syntheses, Characterization and Crystal Structures of Diorganotin(IV) Selenites: 1D Helical Double-Chain Containing Eight-Membered Sn2O4Se2 Inorganic Ring

Three new diorganotin(IV) selenites, [Bu2Sn(O2SeC6H5OMe)2]n (1), [Me2Sn(O2SeC6H4CHMe2)2]n (2), [Me2Sn(O2SeC6H4Et)2]n (3) have been synthesized and structurally characterized by elemental analysis, FT-IR, NMR (1H, 13C and 119Sn) spectra, TGA, and X-ray crystallography. The X-ray reveals that complexes 1–3 are 1D infinite double-chain polymers. The molecular of complex 1 is further linked by intermolecular C–H···O interactions to form a 2D network polymer. Complex 3 is linked by C–H···O interactions to form a 3D organotin framework.

catena-Poly[[trimethyl-tin(IV)]-μ-phenyl-seleninato-κO:O'].

In the title polymeric coordination compound, [Sn(CH3)3(C6H5O2Se)]n, the SnIV atom has a distorted trigonal–bipyramidal geometry, with two O atoms of two symmetry-related bridging phenylseleninate anions in axial positions and three methyl groups in equatorial positions. In the crystal, the complex exhibits a chain structure parallel to the b axis.

Synthesis, structures and magnetic properties of heterobimetallic RuIII–3d (3d = Mn, Ni) compounds based on the chiral RuIII building block

Two pairs of chiral cyano-bridged heterobimetallic compounds, [Mn(salen)Ru((R,R)-(5-Br-salcy))(CN)2]n (1), [Mn(salen)Ru((S,S)-(5-Br-salcy))(CN)2]n (2), [Ni(tren)][Ru((R,R)-(5-Cl-salcy))(CN)2]2 (3), and [Ni(tren)][Ru((S,S)-(5-Cl-salcy))(CN)2]2 (4) [salcy2− = N,N′-(1,2-cyclohexanediylethylene) bis(salicylideneiminato) dianion, tren = tri(2-aminoethyl)amine], have been synthesized and characterized by elemental analysis, IR spectroscopy, X-ray diffraction analyses, and circular dichroism (CD) and vibrational circular dichroism (VCD) spectra. Single X-ray diffraction analysis reveals that complexes 1 and 2 possess a chiral 1D zigzag chain structure that consists of alternating (R,R/S,S)-trans-[Ru(5-Br-salcy)(CN)2]− and [MnIII(salen)]+ units. Complexes 3 and 4 are trinuclear complexes in which the central Ni(II) ion is coordinated with two terminal (R,R/S,S)-trans-[Ru(5-Cl-salcy)(CN)2]− units through cyanide bridges. Investigation of magnetic susceptibilities indicates that antiferromagnetic coupling exists between the cyano-bridged RuIII and MnIII ions for complexes 1 and 2. An estimation of the barrier size (Ea) for 1 reveals a value of 19.1 K, with a characteristic time (τ0) of 1.95 × 10−8. Moreover, complexes 3 and 4 exhibit ferromagnetic coupling between RuIII and NiII through the cyanide bridges with J = 2.73 cm−1.

Syntheses, structures and anti-tumor activity of four organotin(IV) dicarboxylates based on (1,3,4-thiadiazole-2,5-diyldithio)diacetic acid

Four novel organotin complexes, [(Me3Sn)2(O2CCH2S)2C2N2S]n (1), [(Me2Sn)2(O2CCH2S)2C2N2S(μ3-O)]n (2), [(n-Bu3Sn)2(O2CCH2S)2C2N2S]n (3) and [(n-Bu2Sn)(O2CCH2S)2C2N2S]n (4), derived from flexible (1,3,4-thiadiazole-2,5-diyldithio)diacetic acid (H2tzda), have been synthesized and characterized by elemental analysis, FT-IR, NMR and X-ray crystallography. The structural analysis reveals that complexes 1 and 2 display a 1D pipeline-like and 1D ladder chain structure, respectively. Complex 1 contains interconnected 26-membered macrocycles, while complex 2 is made up of the typical ladder tetraorganodistannoxane unit containing 26-membered macrocycles. In addition, the molecules of complexes 1 and 2 are further linked through intermolecular C–H⋯O interactions into a 3D and 2D infinite supramolecular structure, respectively. Complex 3 shows a 2D corrugated polymeric structure constructed by 34-membered macrocycles. Complex 4 adopts a 1D infinite chain structure. Furthermore, in vitro cytotoxicity investigations of complexes 1, 3 and 4 were conducted. Importantly, further cytotoxic assessments of complex 3 against human hepatocellular carcinoma cells (HepG-2) demonstrate that complex 3 could induce an apoptotic retardation effect on proliferation via possible mitochondrial-dependent cross-talk between various signaling proteins and the intracellular p53-Bax-caspases approach should be the major pathway of apoptosis.

CCDC 753487: Experimental Crystal Structure Determination

Related Article: Chunlin Ma, Mengjie Guo, Jing Ru, Rufen Zhang, Qingfeng Wang|2011|Inorg.Chim.Acta|378|213|doi:10.1016/j.ica.2011.08.068