Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Jinghua Xu is active.

Publication


Featured researches published by Jinghua Xu.


Journal of Chromatography A | 2009

Mechanistic studies on the chiral recognition of polysaccharide-based chiral stationary phases using liquid chromatography and vibrational circular dichroism Reversal of elution order of N-substituted alpha-methyl phenylalanine esters

Shengli Ma; Sherry Shen; Heewon Lee; Magnus Eriksson; Xingzhong Zeng; Jinghua Xu; Keith R. Fandrick; Nathan K. Yee; Chris H. Senanayake; Nelu Grinberg

Enantiomeric separation of two aromatic alpha-substituted alanine esters was achieved on two commercially available polysaccharide-based chiral stationary phases (CSPs): amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) and cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC). The interactions between enantiomeric analytes and the CSPs were investigated using chromatographic methods and vibration circular dichroism (VCD). The two analytes differ on the aromatic portion of the molecules where one analyte has a pi-acceptor aromatic ring (1) while the other has a pi-donor aromatic ring (2). When an ADMPC CSP was employed, an increase in the polarity of the mobile phase leads to a reversal of the elution order for the two enantiomers of 1. The elution order of compound 2 was not affected by the polarity of the mobile phase. In order to gain an understanding of these phenomena, the enantiomeric separation of 1 and 2 was also performed on the CDMPC CSP. Interestingly, no reversal of elution order was observed upon the chromatographic separation of both pairs of enantiomers of compounds 1 and 2 upon increasing the solvent polarity when a CDMPC CSP was utilized. To understand the underlying mechanism governing these chiral separations, VCD was applied to study the structure of the ADMPC and CDMPC polymers and their conformational behaviors under chromatographic conditions. For the first time the conformations of the side chains of both polymers were revealed based on the VCD spectra along with DFT calculations. Furthermore, the interactions between the two analytes and the two CSPs were directly probed by VCD. By comparing the spectral differences of the two CSPs in the presence of the two analytes, the detailed interactions involving different functional groups associated with the chiral recognition were elucidated and thus explained the unusual reversal of elution order associated with increasing solvent polarity.


Journal of Organic Chemistry | 2006

Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

Nathan K. Yee; Vittorio Farina; Ioannis N. Houpis; Nizar Haddad; Rogelio P. Frutos; Fabrice Gallou; Xiao-Jun Wang; Xudong Wei; Robert D. Simpson; XuWu Feng; Victor Fuchs; Yibo Xu; Jonathan Tan; Li Zhang; Jinghua Xu; Lana L. Smith-Keenan; Jana Vitous; Michael D. Ridges; and Earl M. Spinelli; Michael E. Johnson; Kai Donsbach; Thomas Nicola; Michael Brenner; Eric Winter; and Paul Kreye; Wendelin Samstag


Archive | 2006

Process for preparing macrocyclic compounds

Carl A. Busacca; Vittorio Farina; Fabrice Gallou; Nizar Haddad; Xiao-Jun Wang; Xudong Wei; Jinghua Xu; Yibo Xu; Nathan K. Yee; Li Zhang


Journal of Organometallic Chemistry | 2006

Olefin ring-closing metathesis as a powerful tool in drug discovery and development – potent macrocyclic inhibitors of the hepatitis C virus NS3 protease

Youla S. Tsantrizos; Jean-Marie Ferland; Andrew McClory; Martin Poirier; Vittorio Farina; Nathan K. Yee; Xiao-Jun Wang; Nizar Haddad; Xudong Wei; Jinghua Xu; Li Zhang


Organic Letters | 2004

Synthesis of 5-Bromopyridyl-2-magnesium Chloride and Its Application in the Synthesis of Functionalized Pyridines

Jinhua J. Song; Nathan K. Yee; Zhulin Tan; Jinghua Xu; and Suresh R. Kapadia; Chris H. Senanayake


Journal of Organic Chemistry | 2007

Practical stereoselective synthesis of an α -trifluoromethyl -α -alkyl epoxide via a diastereoselective trifluoromethylation reaction

Jinhua J. Song; Zhulin Tan; Jinghua Xu; Jonathan T. Reeves; Nathan K. Yee; Ranjit Ramdas; Fabrice Gallou; Katie Kuzmich; Lisa Delattre; Heewon Lee; XuWu Feng; Chris H. Senanayake


Archive | 2005

Process for preparing macrocyclic dipeptides which are suitable for the treatment of hepatitis c viral infections

Carl A. Busacca; Vittorio Farina; Fabrice Gallou; Nizar Haddad; Xiao-Jun Wang; Xudong Wei; Jinghua Xu; Yibo Xu; Nathan K. Yee; Li Zhang


Journal of Organic Chemistry | 2005

A Novel One-Step Synthesis of 2-Substituted 6-Azaindoles from 3-Amino-4-picoline and Carboxylic Esters

Jinhua J. Song; Zhulin Tan; Fabrice Gallou; Jinghua Xu; Nathan K. Yee; Chris H. Senanayake


Archive | 2005

Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

Jinhua J. Song; Zhulin Tan; Jinghua Xu; Nathan K. Yee; Chris H. Senanayake


Organic Process Research & Development | 2007

Development of an Asymmetric Acetate Aldol Reaction with a Trifluoromethyl Ketone

Jinhua J. Song; Jinghua Xu; Zhulin Tan; Jonathan T. Reeves; Nelu Grinberg; Heewon Lee; Katie Kuzmich; XuWu Feng; Nathan K. Yee; Chris H. Senanayake

Collaboration


Dive into the Jinghua Xu's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Li Zhang

Boehringer Ingelheim

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Yibo Xu

Boehringer Ingelheim

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge