Jingliang Dong

Fluid-structure interaction analysis of the left coronary artery with variable angulation

The aim of this study is to elucidate the correlation between coronary artery branch angulation, local mechanical and haemodynamic forces at the vicinity of bifurcation. Using a coupled fluid–structure interaction (FSI) modelling approach, five idealized left coronary artery models with various angles ranging from 70° to 110° were developed to investigate the influence of branch angulations. In addition, one CT image-based model was reconstructed to further demonstrate the medical application potential of the proposed FSI coupling method. The results show that the angulation strongly alters its mechanical stress distribution, and the instantaneous wall shear stress distributions are substantially moderated by the arterial wall compliance. As high tensile stress is hypothesized to cause stenosis, the left circumflex side bifurcation shoulder is indicated to induce atherosclerotic changes with a high tendency for wide-angled models.

Comparative numerical modeling of inhaled micron-sized particle deposition in human and rat nasal cavities

Abstract Micron-sized particle deposition in anatomically realistic models of a rat and human nasal cavity was numerically investigated. A steady laminar inhalation flow rate was applied and particles were released from the outside air. Particles showing equivalent total particle deposition fractions were classified into low, medium and high inertial particle. Typical particle sizes are 2.5, 9 and 20 μm for the human model and 1, 2 and 3 μm for the rat model, respectively. Using a surface-mapping technique the 3D nasal cavity surface was “unwrapped” into a 2D domain and the particle deposition locations were plotted for complete visual coverage of the domain surface. The total surface area comparison showed that the surface area of the human nasal model was about ten times the size of the rat model. In contrast, the regional surface area percentage analysis revealed the olfactory region of the rat model was significantly larger than all other regions making up ∼55.6% of the total surface area, while that of the human nasal model only occupying 10.5%. Flow pattern comparisons showed rapid airflow acceleration was found at the nasopharynx region and the nostril region for the human and rat model, respectively. For the human model, the main passage is the major deposition region for micro-particles. While for the rat model, it is the vestibule. Through comparing the regional deposition flux between human and rat models, this study can contribute towards better extrapolation approach of inhalation exposure data between inter-subject species.

From the Cover: Comparative Numerical Modeling of Inhaled Nanoparticle Deposition in Human and Rat Nasal Cavities

To gain a better understanding of nanoparticle exposure in human nasal cavities, laboratory animals (e.g. rat) are used for in vivo studies. However, due to anatomical differences between human and rodent nasal cavities, direct particle deposition comparisons between species are difficult. This paper presents a comparative nanoparticle (1 nm, 10 nm, and 100 nm) deposition study using anatomically realistic models of a human and rat nasal cavity. The particle deposition fraction was highest consistently in the main nasal passage, for all nanoparticles tested, in the human model; whereas this was only the case for 10 nm, and 100 nm particles for the rodent model, where greater deposition was found in the anterior nose for 1 nm particles. A deposition intensity (DI) term was introduced to represent the accumulated deposition fraction on cross-sectional slices. A common and preferential deposition site in the human model was found for all nanoparticles occurring at a distance of 3.5 cm inside the nasal passage. For the rodent model maximum DI occurred in the vestibule region at a distance of 0.3 cm, indicating that the rodent vestibule produces exceptionally high particle filtration capability. We also introduced a deposition flux which was a ratio of the regional deposition fraction relative to the regions surface area fraction. This value allowed direct comparison of deposition flux between species, and a regional extrapolation scaling factor was found (e.g. 1/10 scale for vestibule region for rat to human comparison). This study bridges the in vitro exposure experiments and in vivo nanomaterials toxicity studies, and can contribute towards improving inter-species exposure extrapolation studies in the future.

Image-based computational hemodynamics evaluation of atherosclerotic carotid bifurcation models

Widely accepted treatment for carotid artery stenosis includes stenting as well as carotid endoarterectomy (CEA), despite complications associated with distal embolism. Therefore pre-screening for evaluating the extent of a stenosis is critically important before undertaking surgical procedures. This study presents and evaluates the feasibility of implementing a virtual computational hemodynamics platform for clinical use to determine the severity of a stenosis and give guidance for surgical decision making. The virtual platform incorporates high-resolution three-dimensional angiography results with Computational Fluid Dynamics modeling to determine clinically related indicators. This includes wall shear stress (WSS), the spatial and temporal hemodynamic changes of blood flow within patient-specific carotid bifurcations, pressure drop coefficient, and severity stratification. The turn-around time for each computational modeling stage was examined which showed that the total time cost is practical and the proposed hemodynamics evaluation platform is reasonably efficient for clinical diagnosis. Furthermore the virtual platform may be used to detect the hemodynamic consequence of atherogenesis, which can then be addressed and quantified based on the distribution of WSS related flow indicators on the abnormal luminal fractions. Additional functional evidence and data can be used by the overseeing physician to enrich and complement the anatomical information for more in-depth evaluation of stenosis in a reasonable time duration.

Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity

In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10µm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery.

Detailed deposition analysis of inertial and diffusive particles in a rat nasal passage

Abstract Rats have been widely used as surrogates for evaluating the health effects of inhaled airborne particulate matter. To provide a thorough understanding of particle transport and deposition mechanisms in the rat nasal airway, this article presents a computational fluid dynamics (CFD) study of particle exposure in a realistic rat nasal passage under a resting flow condition. Particles covering a diameter range from 1 nm to 4 µm were passively released in front of the rat’s breathing zone, and the Lagrangian particle tracking approach was used to calculate individual particle trajectories. Detailed particle deposition analysis shows the deposition of inertial particles >2 µm is high in the rat nasal vestibule and more than 70% of all inhaled inertial particles were trapped in this region. While for diffusive nanoparticles, the vestibule filtration effect is reduced, only less than 60% of inhaled nanoparticles were blocked by the anterior nasal structures. The particle exposure in the olfactory region only shows notable deposition for diffusive nanoparticles, which peaks at 9.4% for 5 nm particles. Despite the olfactory deposition remains at a low level, the ratio between the olfactory and the main passage is kept around 30–40% for 10–800 nm particles, which indicates a particle-size-independent distribution pattern in the main nasal passage and olfactory. This study provides a deep understanding of particles deposition features in a rat nasal passage, and the research findings can aid toxicologist in inter-species exposure-response extrapolation study.

Geometry and airflow dynamics analysis in the nasal cavity during inhalation

BACKGROUND A major issue among computational respiratory studies is the wide variety of nasal morphologies being studied, caused by both inter-population and inter-subject variations. METHOD Six nasal cavity geometries exhibiting diverse geometry variations were subjected to steady inhalation flow rate of 15L/min. to determine if any consistent flow behaviour could be found. FINDINGS Despite vastly different geometries we were able to identify consistent flow patterns including relatively high velocity in the nasal valve region, followed by flow continuing predominantly in the inferior half of the airway. We also found conformity among models where the inhaled air reached a near-conditioned state by the middle of the nasal cavity. Air from the front of the face reached the olfactory regions while air from the lateral sides of the face moved through the inferior half of the nasal cavity. INTERPRETATION The ability to predict gross flow features provides a baseline flow field to compare against. This contributes towards establishing well defined flow predictions and be used as a comparison for future larger studies.

Air conditioning analysis among human nasal passages with anterior anatomical variations

A major functional role of the nasal cavity is air conditioning of the inspired environmental air to near alveolar conditions. It is well known that the anatomical disparities among nasal passages can change airflow patterns to a great extent. However, its effect on nasal air conditioning performance remains largely unexplored. This research investigated the nasal air conditioning performance among nasal models with distinct vestibule phenotypes, including subjects with and without vestibule notches. For the mass transfer, we used a two-film theory model to determine the species transport. Airflow patterns, heat and mass transfer between the inhaled airflow and the nasal mucosa were analysed and compared. Results showed that the nasal air conditioning performance is closely related to nasal passage structures. The anatomical variations, especially the geometry changes in the anterior vestibule region, can increase both heat and mass transfer rate between nasal mucous and respiratory air at the vicinity of the notched regions, while for other regions such as the anterior superior nasal cavity, the heat transfer is greatly reduced to even zero heat flux due to lack of active airflow passing.

Partitioning of dispersed nanoparticles in a realistic nasal passage for targeted drug delivery

&NA; The complex nasal structure poses obstacles for efficient nasal drug administration beyond the nasal valve, especially when targeting the olfactory region. This study numerically detailed the naturally inhaled nanoparticle transport process from the initial releasing locations to the final deposited sites using a realistic human nasal passage. Dispersed nanoparticles at different coronal cross‐sections were partitioned into multiple groups according to their final deposited locations. Results showed inhaled nanoparticles are more likely to move along the septum. Olfactory deposited particles entered the nose through the inner superior corner of the nostril; the middle meatus deposited particles entered the nose through the top third of the nostril; the inferior deposited particles entered via the bottom floor regions of the nostril. Therefore, targeted nasal inhalation therapies that intentionally release therapeutic particles from these recognized regions at the nostril plane can considerably improve the resultant topical disposition doses. However, it remains challenging to completely prevent undesired particle depositions as particles coming from the same location may produce multiple‐sites depositions due to partition overlapping. Nevertheless, the fraction of undesired particle deposition is anticipated to be reduced at a great extent compared to unplanned releasing approaches. Graphical abstract Figure. No caption available.

Numerical air conditioning performance assessment of nasal models with morphologic variations

A major functional role of the nasal cavity is air conditioning of the inspired environmental air to nearly alveolar conditions in order to protect the moist and warm alveolar lining where gas exchange takes place. It is well known that the morphological disparities among nasal passages can change airflow patterns to a great extent. However, this morphological variation effect on air conditioning performance remains unclear. This research aims to investigate the nasal air conditioning performance among nasal models with distinct vestibule phenotypes across subjects with normal healthy nasal anatomy and with symptoms of nasal disease. Numerical simulations considering humidified air with room temperature condition was conducted. Airflow pattern, heat and mass transfer between the inhaled airflow and the nasal mucosa were analysed and compared among selected nasal models. Results showed that the nasal air conditioning performance is closely related to nasal structures, and its morphological variations, especially in the nasal vestibule region, can induce up to 25% relative humidity, 3 °C temperature changes in anterior nasal region.