Jingya Yang

Hydrocyanation of sulfonylimines using potassium hexacyanoferrate(II) as an eco-friendly cyanide source

An efficient and eco-friendly method for hydrocyanation of sulfonylimines via one-pot two-step procedure using potassium hexacyanoferrate(II) as a cyanide source, benzoyl chloride as a promoter, and potassium carbonate as a base is described. This protocol has the features of using nontoxic, nonvolatile and inexpensive cyanide source, high yield, and simple work-up procedure.

Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

Visible light, in combination with the molecular iodine catalyst-mediated α-hydroxylation of α-methylene ketones, has been developed. The reaction proceeds smoothly in methanol at room temperature under aerobic conditions and shows exclusive selectivity toward methylene ketones. Mechanistic studies have revealed that the reaction proceeds by a radical pathway. Renewable energy, metal-free catalyst and abundant oxygen source alongside a wide scope and novel selectivity are features that make this strategy practical and eco-friendly.

Selective Monohydrocyanation of Diimine using Potassium Hexacyanoferrate(II)-Benzoyl Chloride Reagent System as a Cyanide Source

AbstractThe selective monohydrocyanation of diimines using potassium hexacyanoferrate(II)-benzoyl chloride reagent system as a cyanide source under catalyst-free condition is described. The advantages of this protocol are the non-toxic, non-volatile and inexpensive cyanide source, high yield, and simple work-up procedure. Graphical AbstractThe selective monohydrocyanation of diimines using potassium hexacyanoferrate(II)-benzoyl chloride reagent system as cyanide source under catalyst-free condition is described.

Copper-catalyzed synthesis of 1,3,5-triarylpentane-1,5-diones from α,β-unsaturated ketones

An efficient method for copper catalyzed synthesis of 1,3,5-triarylpentane-1,5-diones using α,β-unsaturated ketones as unique starting materials is described. The protocol offers several advantages such as simple, inexpensive reagents, mild reaction conditions and simple work-up procedure.

A concise synthetic method for 1,3,5-triazinane-2,4-dithiones

1,3,5-Triazinane-2,4-dithiones were efficiently synthesized via condensation of 2 equiv. of 1-arylthioureas with 1 equiv. of aliphatic carboxylic acids using ferric chloride hexahydrate as a catalyst. This protocol has the advantages of high yield, mild condition and simple procedure.

Synthesis of 4-arylethyl-6-arylpyrimidine-2-thiols through aza-Michael addition/nucleophilic addition/aromatization tandem reactions

Abstract An efficient method for the synthesis of the title compounds by reactions of divinyl ketones with thiourea is described. This protocol has the advantages of high yields, mild reaction conditions and simple work-up procedure.

Hydrocyanation of 2-arylmethyleneindan-1,3-diones using potassium hexacyanoferrate(II) as a nontoxic cyanating agent

Abstract The hydrocyanation of 2-arylmethyleneindan-1,3-diones with potassium hexacyanoferrate(II) as a nontoxic cyanating agent to synthesize 2-(1,3-dioxoindan-2-yl)-2-arylacetonitriles in the presence of benzoyl chloride as a promoter and potassium carbonate as a base by a one-pot procedure is described. The use of nontoxic and inexpensive cyanide source, high yield and simple workup procedures are the advantages of this protocol.

Catalyst-free sulfa-Michael addition of pyrimidine-2-thiol to nitroolefins

ABSTRACT Catalyst-free sulfa-Michael addition of pyrimidine-2-thiol to nitroolefins is described. A series of 2-((2-nitro-1-arylethyl)thio)pyrimidines were efficiently synthesized. The protocol has advantages of wide range of substituents tolerance, no catalyst, additives and bases, mild condition, and high yield. The method can also extend to gram scale. GRAPHICAL ABSTRACT

Regioselective 1,4-conjugate aza-Michael addition of dienones with benzotriazole

Abstract The regioselective 1,4-conjugate aza-Michael addition of dienones with benzotriazole catalyzed by potassium acetate is described. A series of 3-(benzotriazol-1-yl)-1,5-diarylpent-4-en-1-ones were efficiently synthesized under mild conditions. This protocol has advantages of transition-metal free catalyst, high yield and high regioselectivity.

Aerobic oxidative synthesis of 3,5-disubstituted isoxazoles directly from α,β-unsaturated ketones

Using an efficient aerobic oxidative method, the synthesis of ten 3,5-disubstituted isoxazoles by treatment of α,β-unsaturated ketones with hydroxylamine and NaOH at room temperature has been achieved.