Jinsong Hao
Schering-Plough
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Publication
Featured researches published by Jinsong Hao.
ACS Medicinal Chemistry Letters | 2016
Wen-Lian Wu; Jinsong Hao; Martin Domalski; Duane A. Burnett; Dmitri A. Pissarnitski; Zhiqiang Zhao; Andrew Stamford; Giovanna Scapin; Ying-Duo Gao; Aileen Soriano; Terri M. Kelly; Zuliang Yao; Mary Ann Powles; Shiying Chen; Hong Mei; Joyce Hwa
In our efforts to develop second generation DPP-4 inhibitors, we endeavored to identify distinct structures with long-acting (once weekly) potential. Taking advantage of X-ray cocrystal structures of sitagliptin and other DPP-4 inhibitors, such as alogliptin and linagliptin bound to DPP-4, and aided by molecular modeling, we designed several series of heterocyclic compounds as initial targets. During their synthesis, an unexpected chemical transformation provided a novel tricyclic scaffold that was beyond our original design. Capitalizing on this serendipitous discovery, we have elaborated this scaffold into a very potent and selective DPP-4 inhibitor lead series, as highlighted by compound 17c.
Bioorganic & Medicinal Chemistry Letters | 2007
Bernard R. Neustadt; Jinsong Hao; Neil Lindo; William J. Greenlee; Andrew Stamford; Deen Tulshian; Ennio Ongini; John C. Hunter; Angela Monopoli; Rosalia Bertorelli; Carolyn Foster; Leyla Arik; Jean E. Lachowicz; Kwokei Ng; Kung-I Feng
Archive | 2009
Santhosh Francis Neelamkavil; Craig D. Boyle; Joel M. Harris; Andrew Stamford; Jinsong Hao; Bernardt R. Neustadt; Samuel Chackalamannil; Yan Xia; William J. Greenlee
Bioorganic & Medicinal Chemistry Letters | 2005
Julius J. Matasi; John P. Caldwell; Jinsong Hao; Bernard R. Neustadt; Leyla Arik; Carolyn Foster; Jean E. Lachowicz; Deen Tulshian
Archive | 2004
Bernard R. Neustadt; Jinsong Hao; Hong Liu; Craig D. Boyle; Samuel Chackalamannil; Unmesh G. Shah; Andrew Stamford
Archive | 2005
Bernard R. Neustadt; Jinsong Hao; Hong Liu; Craig D. Boyle; Samuel Chackalamannil; Unmesh G. Shah; Andrew Stamford; Joel M. Harris
Archive | 2010
Santhosh Francis Neelamkavil; Bernard R. Neustadt; Andrew Stamford; Yan Xia; Joel M. Harris; Craig D. Boyle; Samuel Chackalamannil; Dipshikha Biswas; Hong Liu; Jinsong Hao; Claire M. Lankin; Unmesh G. Shah
Archive | 2009
Bernard R. Neustadt; Andrew Stamford; Jinsong Hao; Charles Lee Jayne; Yan Xia
Archive | 2009
Joel M. Harris; Bernard R. Neustadt; Jinsong Hao; Andrew Stamford
Archive | 2009
Bernard R. Neustadt; Andrew Stamford; Jinsong Hao; Charles Lee Jayne; Yan Xia