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Publication
Featured researches published by Jiri Jilek.
European Journal of Pharmacology | 1979
Philip Seeman; Karen Westman; Miroslav Protiva; Jiri Jilek; Padam C. Jain; Anil K. Saxena; Nitya Anand; Leslie G. Humber; Adolf H. Philipp
In order to identify a pair of neuroleptic enantiomers with the highest stereoselective interaction with neuroleptic/dopamine receptors, the effects of eight pairs of neuroleptic enantiomers were tested on the specific binding of 3H-spiperone to crude homogenates of calf caudate nucleus. The ratios of the Ki values were: (+)-butaclamol/(-)-butaclamol = 3000; dexclamol/(-)-analogue = 151; (+)-isobutaclamol/(-)-isobutaclamol = 146; (-)-CTC/(+)-CTC= 109; (-)-centbutindole/(+)-centbutindole = 20; S(+)-octoclothepin/R(-)-octoclothepin = 11. Thus, the neuroleptic receptor is highly stereoselective for the rigid butaclamol derivatives, but much less so for the flexible neuroleptics. The 3H-apomorphine binding site, however, had a stereoselectivity ratio of only 7 for isobutaclamol, further suggesting that the high affinity sites (i.e. nM) for 3H-neuroleptic binding and for 3H-apomorphine binding are different.
Archive | 1974
Miroslav Protiva; Jiri Jilek; Karel Sindelar; Jirina Metysova
Archive | 1990
Miroslav Rotiva; Jiri Jilek; Martin Valchar; Antonín Dlabač; Karel Sindelar; Jirina Metysova; Josef Pomykáček; Natasa Dlohonozkova
Archive | 1967
Miroslav Protiva; Jiri Jilek; Jirina Metysova; Ivan Ernest; Karel Pelz; Edita Adlerova
Archive | 1978
Miroslav Protiva; M. Rajšner; Karel Sindelar; Jiri Jilek; Václav Bártl; Jirina Metysova; Antonín Dlabač; Leon Langsadl; Josef Pomykáček; Frantisek Miksik
Archive | 1978
Miroslav Protiva; Miloslav Dipl Ing Rajsner; Karel Sindelar; Jiri Jilek; Václav Bártl; Jirina Metysova; Antonín Dlabač; Leon Langsadl; Josef Pomykáček; Frantisek Miksik
Archive | 1989
Miroslav Protiva; Jiri Jilek; Martin Valchar; Josef Pomykáček; Natasa Dlohozkova
Archive | 1987
Miroslav Protiva; Jiri Jilek
Archive | 1986
Miroslav Protiva; Jiri Jilek; Irena Červená; Antonín Dlabač; Martin Valchar; Josef Pomykáček
Archive | 1978
M. Rajšner; Miroslav Protiva; Frantisek Miksik; Karel Sindelar; Jirina Metysova; Antonín Dlabač; Václav Bártl; Jiri Jilek; Leon Langsadl; Josef Pomykáček