Jiri Kofranek

The Atlas of Physiology and Pathophysiology: Web-based multimedia enabled interactive simulations

The paper is a presentation of the current state of development for the Atlas of Physiology and Pathophysiology (Atlas). Our main aim is to provide a novel interactive multimedia application that can be used for biomedical education where (a) simulations are combined with tutorials and (b) the presentation layer is simplified while the underlying complexity of the model is retained. The development of the Atlas required the cooperation of many professionals including teachers, system analysts, artists, and programmers. During the design of the Atlas, tools were developed that allow for component-based creation of simulation models, creation of interactive multimedia and their final coordination into a compact unit based on the given design. The Atlas is a freely available online application, which can help to explain the function of individual physiological systems and the causes and symptoms of their disorders.

Parameter estimation of complex mathematical models of human physiology using remote simulation distributed in scientific cloud

A generic system for estimation of model parameters - calibrate models - is introduced. The proposed system architecture is built of several loosely coupled modules behaving as RESTful web services and allowing to integrate other parts of the system via HTTP protocol and data exchanged in JSON format. The system was designed in such a way that the most demanding computational part is computed in parallel and computation may be distributed to remote computational resources. A test deployment was done in scientific cloud provided by czech NGI CESNET. Parameter identification of complex models got significant speedup on cloud computing resources.

Evaluation of Cardiorespiratory Functions during Heart Catheterisation through Simulation Model Identification

The development of personal computers has made it possible for complex computations to be performed during clinical examination in catheterisation laboratories. For this purpose we have developed a mathematical model of blood gas transport, which takes as its input the data gained in the heart catheterisation presented in Table 1. The mathematical realisation of the physiological laws in the simulation model is presented in Appendix I, with the symbols used listed in Appendix II. Incorrect data are rejected and, if the measured data are consistent with physiological relationships, the clinically relevant data presented in Table 2 are calculated.