Jiwu Wen

Asymmetric Synthesis of β‐DDB Through Oxazoline‐Mediated Ullmann Coupling

Abstract Biphenyl lignan (β‐DDB) (2), an effective drug in the treatment of hepatitis, was for the first time asymmetrically synthesized via a chiral oxazoline mediated Ullmann coupling. The two enantiomers of β‐DDB have been obtained in this way by using the optically pure amino alcohols L‐valinol and D‐valinol, respectively. However, attempts to synthesize enantiopure α‐DDB (1) by the same method failed because of the racemization of 1 at room temperature in solution.

Novel Route for Preparation of 7‐Methyl‐camptothecin and Its Possible Mechanism

Abstract A novel route for preparation of 7‐methyl‐camptothecin is described. Its possible mechanism is discussed.

A Convenient Preparation of Enantiopure endo‐2‐Hydroxyepicamphor and endo‐3‐Hydroxycamphor from Camphoric Acid

Abstract From easily available camphoric acid, endo‐2‐hydroxyepicamphor 1 and endo‐3‐hydroxycamphor 2 have been prepared as a mixture which can be further separated to pure forms. This method offers a convenient synthesis of 1 and 2.