Joanna Matysiak

Synthesis and anticancer activity of new 2-aryl-4h-3,1-benzothiazines.

New compounds of 2‐aryl‐4H‐3,1‐benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl‐modified sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with 2‐aminobenzyl alcohols. The reaction proceeded through thiobenzanilide intermediates, which were converted to the 4H‐3,1‐benzothiazine fused ring by an endocyclization process. The structures of compounds were identified from elemental, IR, 1H‐NMR, 13C‐NMR, and MS spectra analyses. The cytotoxicity in vitro against four human cancer cell lines was determined. The antiproliferative properties of some compounds were more beneficial than cisplatin studied comparatively.

Synthesis and Antibacterial Activity of Novel Fused 1,3‐Thiazoles and 1,3‐Thiazines Incorporating a 2,4‐Dihydroxyphenyl Residue

In an attempt to find a new class of antimicrobial agents, a series of benzothiazoles, 1,3‐thiazolo[5,4‐b]pyridines, 4H‐3,1‐benzothiazines, naphtho[2,3‐d][1,3]thiazole‐4,9‐diones and other related compounds containing a 2,4‐dihydroxyphenyl moiety were prepared. They were obtained via the reaction of aryl‐modified sulfinyl[bis(2,4‐dihydroxyphenylmethanethione)]s with appropriate commercial chemical reagents in the endocyclization processes. The MIC values of the compounds towards eight reference bacterial strains were assessed by the two‐fold serial micro‐dilution broth method. They exhibited inhibitory effects against the Gram‐positive strains tested opposite to Gram‐negative ones. Some compounds were more effective than the reference drug. 4‐(6‐Chloro‐4H‐3,1‐benzothiazin‐2‐yl)‐6‐methylbenzene‐1,3‐diol (5b) due to its very good activity (MIC from 1.56 to 3.13u2009µg/mL) and low cytotoxicity (IC50u2009>u200950u2009µg/mL) may be regarded as a promising precursor for the development of novel antibacterial agents.

Synthesis of 2-(2,4-dihydroxyphenyl)thieno-1,3-thiazin-4-ones, their lipophilicity and anticancer activity in vitro

A new one-step synthesis of novel biologically active 2-substituted 2,4-dihydroxyphenyl-4

Synthesis and biological activity of novel 4- and 6-(1-alkyl/aryl-1H-benzimidazol-2-yl)benzene-1,3-diols

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QSAR models of antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazoles in various cancer cell lines

H-thieno[3,2-

Synthesis of 4-(4-methylidene-4H-3,1-benzothiazin-2-yl)benzene1,3-diols and their antiproliferative activity against human cancer cell lines

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