João F. Guassi Moreira

Changes in family cohesion and links to depression during the college transition

Parent relationships remain an important component in the lives of adolescents, with particular respect to their well-being. In the current study, we sought to understand how changes in family cohesion across the high school-college transition may be related to changes in depressive symptoms. Three hundred and thirty-eight college freshman completed self-report measures prior to attending college and again two months into their first semester. Although depressive symptoms significantly increased, adolescents who reported increases in family cohesion reported declines in depressive symptoms during the college transition. Furthermore, this effect was mediated by changes in self-esteem and optimism. Finally, we show unique associations for male and female adolescents, such that changes in family cohesion were only related to changes in depression for girls. Results suggest that parent relationships may buffer against increased depressive symptoms during this important transition period.

Mother still knows best: Maternal influence uniquely modulates adolescent reward sensitivity during risk taking

Adolescent decision-making is highly sensitive to input from the social environment. In particular, adult and maternal presence influence adolescents to make safer decisions when encountered with risky scenarios. However, it is currently unknown whether maternal presence confers a greater advantage than mere adult presence in buffering adolescent risk taking. In the current study, 23 adolescents completed a risk-taking task during an fMRI scan in the presence of their mother and an unknown adult. Results reveal that maternal presence elicits greater activation in reward-related neural circuits when making safe decisions but decreased activation following risky choices. Moreover, adolescents evidenced a more immature neural phenotype when making risky choices in the presence of an adult compared to mother, as evidenced by positive functional coupling between the ventral striatum and medial prefrontal cortex. Our results underscore the importance of maternal stimuli in bolstering adolescent decision-making in risky scenarios.

The Neural Development of Us and Them

Social groups aid human beings in several ways, ranging from the fulfillment of complex social and personal needs to the promotion of survival. Despite the importance of group affiliation to humans, there remains considerable variation in group preferences across development. In the current study, children and adolescents completed an explicit evaluation task of in-group and out-group members during functional neuroimaging. We found that developmental increases in bilateral amygdala, fusiform gryus, and orbitofrontal cortex activation predicted greater propensity for in-group favoritism. Additionally, brain regions implicated in social cognition, such as the dorsomedial prefrontal cortex, showed heighted activation when viewing in-group compared to out-group peers. Our findings suggest that the motivational significance and processing of group membership undergoes important changes across development, with peaks in neural sensitivity to in-group members during adolescence, a period when young people are especially concerned with their social identity.

But is helping you worth the risk? Defining Prosocial Risk Taking in adolescence

Highlights • Changes in the adolescent brain contribute to both risk taking and prosocial behaviors.• Interactions between risk taking, prosociality, and social context remain unstudied.• We propose a new area of study, Prosocial Risk Taking (PSRT).• Prosocial Risk Taking involves helping another individual at a risk to oneself.• Social risks may be more salient than other risk types for PSRT behaviors.

Longitudinal Increases in Parent–Child Relationship Quality and Sensation Seeking Interact to Increase Risk-Taking During the College Transition

We tested two competing predictions of whether changes in parent–child relationship quality buffer or exacerbate the association between sensation-seeking and risk-taking behaviors as individuals gain more independence during the high school–college transition. In the current longitudinal study, 287 participants completed self-report measures of sensation seeking, risk-taking, and parent–child relationship quality with their parents prior to starting college and again during their first semester. Overall, students displayed increases in risky behaviors, which were predicted by sensation seeking. Changes in relationship quality moderated the association between sensation seeking and risk-taking, such that sensation seeking predicted higher risk-taking behaviors during the first semester of college, but only for those who reported increases in relationship quality across the college transition. These results suggest that increased relationship quality may have an inadvertent spillover effect by interacting with sensation seeking to increase risky behaviors.

Family conflict is associated with longitudinal changes in insular-striatal functional connectivity during adolescent risk taking under maternal influence

Maternal presence has marked effects on adolescent neurocognition during risk taking, influencing teenagers to make safer decisions. However, it is currently unknown whether maternal buffering changes over the course of adolescence itself, and whether its effects are robust to individual differences in family relationship quality. In the current longitudinal study, 23 adolescents completed a risk-taking task under maternal presence during an fMRI scan before and after the transition to high school. Behavioral results reveal that adolescent risk taking increased under maternal presence across a one-year period. At the neural level, we found that adolescents reporting higher family conflict showed longitudinal increases in functional coupling between the anterior insula (AI) and ventral striatum (VS) when making safe decisions in the presence of their mother, which was associated with increased real-world risk taking. These findings show that individual differences in family relationship quality undermine effective development of AI-VS connectivity resulting in increased risk taking.

Spatial and Temporal Cortical Variability Track with Age and Affective Experience During Emotion Regulation in Youth

Variability is a fundamental feature of human brain activity that is particularly pronounced during development. However, developmental neuroimaging research has only recently begun to move beyond characterizing brain function exclusively in terms of magnitude of neural activation to incorporate estimates of variability. No prior neuroimaging study has done so in the domain of emotion regulation. We investigated how age and affective experiences relate to spatial and temporal variability in neural activity during emotion regulation. In the current study, 70 typically developing youth aged 8-17 years completed a cognitive reappraisal task of emotion regulation while undergoing functional magnetic resonance imaging. Estimates of spatial and temporal variability during regulation were calculated across a network of brain regions, defined a priori, and were then related to age and affective experiences. Results showed that increasing age was associated with reduced spatial and temporal variability in a set of frontoparietal regions (e.g., dorsomedial prefrontal cortex, superior parietal lobule) known to be involved in effortful emotion regulation. In addition, youth who reported less negative affect during regulation had less spatial variability in the ventrolateral prefrontal cortex, which has previously been linked to cognitive reappraisal. We interpret age-related reductions in spatial and temporal variability as implying neural specialization. These results suggest that the development of emotion regulation is undergirded by a process of neural specialization and open up a host of possibilities for incorporating neural variability into the study of emotion regulation development.

Parents versus peers: Assessing the impact of social agents on decision making in young adulthood

Young adulthood is a developmental phase when individuals must navigate a changing social milieu that involves considering how their decisions affect close others such as parents and peers. To date, no empirical work has directly evaluated how young adults weigh these relationships against one another. We conducted a preregistered experiment in which we pitted outcomes for parents against outcomes for friends. Participants (N = 174, ages 18–30 years) played two runs of the Columbia Card Task—one in which gains benefited a parent and losses were incurred by a friend and another in which the opposite was true. We also tested whether age, relationship quality, and reward type earned for parents and friends (simulated vs. real) acted as moderating influences on parent–friend prioritization. Results showed that individuals were more likely to make decisions that benefited a parent at the expense of a friend. Relationship quality and reward type moderated this effect, whereas age did not.

Capacity and tendency: A neuroscientific framework for the study of emotion regulation

It is widely accepted that the ability to effectively regulate ones emotions is a cornerstone of physical and mental health. As such, it should come as no surprise that the number of neuroimaging studies focused on emotion regulation and associated processes has increased exponentially in the past decade. To date, neuroimaging research on this topic has examined two distinct but complementary features of emotion regulation - the capacity to effectively utilize a strategy to regulate emotion and to a lesser extent, the tendency to choose to regulate. However, theoretical accounts of emotion regulation have only recently begun to distinguish capacity from tendency. In the present review, we provide a novel framework for conceptualizing these two intertwined, yet distinct, facets of emotion regulation. First we characterize brain regions that support emotion generation and are thus targeted by emotion regulation. Next, we synthesize findings from the dozens of neuroimaging studies that have examined emotion regulation capacity, focusing in particular on the most commonly studied emotion regulation strategy - reappraisal. Finally, we discuss emerging neuroimaging research examining state and trait regulatory tendencies. We conclude by integrating findings from neuroimaging research on emotion regulation capacity and tendency and suggest ways that this integrated model can inform basic and translational neuroscientific research on emotion regulation.