João Paulo M. Santos

Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals

Osteoarthritis (OA) is the most prevalent disease of the musculoskeletal system and it has an important genetic component. Despite several reports have shown the involvement of pro-inflammatory cytokine such as interleukin-1β and TNF-α, the role of interleukin-6 (IL-6) in osteoarthritis is still unclear. Thus, this study aimed to analyze the relationship between the single nucleotide polymorphism in the portion -572 of the promoter region of the IL6 gene (SNP -572G/C) with hip and knee OA in the elderly. In this case-control study, 257 physically independent elderly were recruited (case group: 92 individuals with osteoarthritis and control group: 165 individuals with no osteoarthritis). Blood samples were collected from patients for the DNA fragments extraction and amplification by real-time polymerase chain reaction (PCR) by TaqMan system for subsequent genotyping of IL6 gene. The degree of joint damage was assessed by radiographic classification based on the criteria of Kellgren and Lawrence. The functional status was evaluated by Lequesne and WOMAC questionnaires. It was observed that individuals carrying the C allele have lower susceptibility to osteoarthritis (OR=0.51, 95% CI: 0.32-0.80, p=0.004) and less radiological impairment for both hip (Fisher-Freeman-Halton test=4.2 and p=0.04) and knee joints (Fisher-Freeman-Halton test=4.7 and p=0.03). Regarding functional status, individuals carrying the C allele has a lower degree of functional impairment assessed by WOMAC (Mann-Whitney test, p=0.04), although no difference was observed in the Lequesne questionnaire (p>0.05). Additionally, it was observed a marked reduction in IL-6 serum levels in individuals with GC and CC genotypes when compared to individuals harboring GG genotype. In conclusion, the polymorphism -572G/C IL6 is a protective factor for the presence and severity of hip and knee osteoarthritis in the elderly. Further prospective studies with large sample size and methods (e.g. effect of this polymorphism on gene expression, haplotype analysis for IL-6 promoter polymorphism) are needed to validate this study findings.

Análise da influência da farmacoterapia sobre a qualidade de vida em idosos com osteoartrite

AIMS This study aimed to assess the influence of pharmacotherapy on health-related quality of life of elderly with ostheoartritis. METHODS Longitudinal study involving 91 older adults from both genders (Age: 70.36±5.57 years) from EELO project with self-reported knee or hip ostheoartritis, confirmed by radiographic analysis. Data regarding pharmacotherapy was assessed by a structured questionnaire and the quality of life was analyzed by SF-36 questionnaire at the initial moment and two years thereafter. All domains from quality of life were grouped in physical and mental components for further data analysis. RESULTS A statistically significant decline in health-related quality of life was observed (Wilcoxon test, p<0.05). However, it was observed a slighted decline in physical components in group treated with chondroitin/glucosamine when compared to other groups, according to Kruskal-Wallis test (p=0.007). On the other hand, it was not observed any influence of pharmacological treatment on mental components of health-related quality of life (p>0.05). CONCLUSIONS Treatment with condroitin/glucosamin contributes to a lower decline in physical component while it had no influence on mental component of health-related quality of life in older adults with ostheoartritis.

Uso do questionário Lower Extremity Functional Scale (LEFS‐Brasil) em comparação com o Índice Algofuncional de Lequesne para definição de gravidade na osteoartrite de joelho e quadril

Osteoarthritis (OA) is a chronic joint disease with a high prevalence in the elderly.1 OA affects more often the hip and knee, compromising important aspects in activities of daily living such as walking, transposition of obstacles, home care and work activities.2 Several questionnaires have emerged to evaluate the functional capacity of patients with OA, which stand out by their simplicity and the ability to evaluate the perception of the

Relation of plantar pressure and range of movement of the lower limbs with the risk of falls in older women

Objetivou-se verificar a influencia das variaveis de pressao plantar e amplitude de movimento (ADM) de quadril, joelho e tornozelo sobre o risco de quedas em idosas. Participaram 39 idosas, avaliando-se a Pressao Maxima e Media sobre a plataforma de baropodometria. Em seguida, realizou-se o teste Timed Up and Go (TUG) e posteriormente a avaliacao da ADM de flexao de quadril e joelho e flexao plantar e dorsal de tornozelo por meio de um goniometro. As variaveis baropodometricas (Pressao Maxima e Pressao Media) tenderam a influenciar os valores do TUG conforme valor do teste de hipotese (p=0,051), demonstrando correlacao moderada (r=0,487), com destaque para a Pressao Maxima, que apresentou correlacao significativa com o TUG (p<0,005). Entretanto, a ADM articular de quadril, joelho e tornozelo nao apresentaram correlacoes significativas entre as variaveis baropodometricas e risco de quedas. Sobre a analise da associacao entre o TUG, categorizado em baixo e medio risco de quedas, e as quedas, nao foram observadas diferencas (p=0,475). O aumento da pressao maxima apresentou relacao com o risco de quedas, mas a ADM de quadril, joelho e tornozelo nao apresentaram relacao sobre o risco de quedas e as variaveis baropodometricas na populacao investigada.172 Relation of plantar pressure and range of movement of the lower limbs with the risk of falls in older women Relação da pressão plantar e amplitude de movimento de membros inferiores com o risco de quedas em idosas Relación entre la presión plantar y la amplitud de los movimientos de los miembros inferiores y el riesgo de caídas en adultos mayores Mayara Luca Vareschi Lopes1, João Paulo Manfre dos Santos2, Karen Barros Parron Fernandes3, Fernando Raphael Pinto Guedes Rogério1, Rosemari Queiroz de Freitas4, Deise Aparecida de Almeida Pires-Oliveira3

Relación entre la presión plantar y la amplitud de los movimientos de los miembros inferiores y el riesgo de caídas en adultos mayores

Objetivou-se verificar a influencia das variaveis de pressao plantar e amplitude de movimento (ADM) de quadril, joelho e tornozelo sobre o risco de quedas em idosas. Participaram 39 idosas, avaliando-se a Pressao Maxima e Media sobre a plataforma de baropodometria. Em seguida, realizou-se o teste Timed Up and Go (TUG) e posteriormente a avaliacao da ADM de flexao de quadril e joelho e flexao plantar e dorsal de tornozelo por meio de um goniometro. As variaveis baropodometricas (Pressao Maxima e Pressao Media) tenderam a influenciar os valores do TUG conforme valor do teste de hipotese (p=0,051), demonstrando correlacao moderada (r=0,487), com destaque para a Pressao Maxima, que apresentou correlacao significativa com o TUG (p<0,005). Entretanto, a ADM articular de quadril, joelho e tornozelo nao apresentaram correlacoes significativas entre as variaveis baropodometricas e risco de quedas. Sobre a analise da associacao entre o TUG, categorizado em baixo e medio risco de quedas, e as quedas, nao foram observadas diferencas (p=0,475). O aumento da pressao maxima apresentou relacao com o risco de quedas, mas a ADM de quadril, joelho e tornozelo nao apresentaram relacao sobre o risco de quedas e as variaveis baropodometricas na populacao investigada.172 Relation of plantar pressure and range of movement of the lower limbs with the risk of falls in older women Relação da pressão plantar e amplitude de movimento de membros inferiores com o risco de quedas em idosas Relación entre la presión plantar y la amplitud de los movimientos de los miembros inferiores y el riesgo de caídas en adultos mayores Mayara Luca Vareschi Lopes1, João Paulo Manfre dos Santos2, Karen Barros Parron Fernandes3, Fernando Raphael Pinto Guedes Rogério1, Rosemari Queiroz de Freitas4, Deise Aparecida de Almeida Pires-Oliveira3

Relação da pressão plantar e amplitude de movimento de membros inferiores com o risco de quedas em idosas

Objetivou-se verificar a influencia das variaveis de pressao plantar e amplitude de movimento (ADM) de quadril, joelho e tornozelo sobre o risco de quedas em idosas. Participaram 39 idosas, avaliando-se a Pressao Maxima e Media sobre a plataforma de baropodometria. Em seguida, realizou-se o teste Timed Up and Go (TUG) e posteriormente a avaliacao da ADM de flexao de quadril e joelho e flexao plantar e dorsal de tornozelo por meio de um goniometro. As variaveis baropodometricas (Pressao Maxima e Pressao Media) tenderam a influenciar os valores do TUG conforme valor do teste de hipotese (p=0,051), demonstrando correlacao moderada (r=0,487), com destaque para a Pressao Maxima, que apresentou correlacao significativa com o TUG (p<0,005). Entretanto, a ADM articular de quadril, joelho e tornozelo nao apresentaram correlacoes significativas entre as variaveis baropodometricas e risco de quedas. Sobre a analise da associacao entre o TUG, categorizado em baixo e medio risco de quedas, e as quedas, nao foram observadas diferencas (p=0,475). O aumento da pressao maxima apresentou relacao com o risco de quedas, mas a ADM de quadril, joelho e tornozelo nao apresentaram relacao sobre o risco de quedas e as variaveis baropodometricas na populacao investigada.172 Relation of plantar pressure and range of movement of the lower limbs with the risk of falls in older women Relação da pressão plantar e amplitude de movimento de membros inferiores com o risco de quedas em idosas Relación entre la presión plantar y la amplitud de los movimientos de los miembros inferiores y el riesgo de caídas en adultos mayores Mayara Luca Vareschi Lopes1, João Paulo Manfre dos Santos2, Karen Barros Parron Fernandes3, Fernando Raphael Pinto Guedes Rogério1, Rosemari Queiroz de Freitas4, Deise Aparecida de Almeida Pires-Oliveira3