Joao Rui B. Alencar

Lapachol: segurança e eficácia na terapêutica

O Lapachol e uma naftoquinona isolada de varias especies de plantas da familia Bignoniaceas, encontrado facilmente nas regioes norte e nordeste do Brasil. Conhecido por suas propriedades anticancerigenas, possui ainda antiinflamatoria, analgesica, antibiotica, antimalaria antitripanossoma, e antiulcerogenica. O LAFEPE® em parceria com o Departamento de Antibioticos da Universidade Federal de Pernambuco - UFPE disponibiliza o Lapachol na forma de capsulas de 250 mg e pretende, com este trabalho, apresentar uma revisao bibliografica sobre a seguranca e eficacia do Lapachol na terapeutica de modo a proporcionar uma maior difusao de conhecimentos na sua prescricao e torna-lo medicamento de referencia dentro da politica de genericos do pais.

Validação de limpeza de zidovudina: estratégia aplicada ao processo de fabricação de medicamentos anti-retrovirais

The cleaning validation is integrant part of the laws of good manufacturing practices of medicines. Cleaning validation procedures are carried out in order to assure that residues are within acceptable limits after the cleaning process. Very little has been published regarding practices within the pharmaceutical industry. This work presents a strategy for cleaning validation of the process equipments of the medicine zidovudine produced by LAFEPE (Recife - PE, Brazil) utilized in AIDS treatment. An analytical method by spectrofotometry and samples surfaces by swab was utilized. The acceptance criteria from the cleaning utilized was 10 ppm of zidovudine in the subsequent product (stavudine). The residues of zidovudine found in the equipment after cleaning were lower that limits established as well as to the smaller level of concentration capable of producing pharmacological effects.