João Torres

MP45-09 EFFECTS OF CASTRATION AND TESTOSTERONE REPLACEMENT OVER SEROTONIN (PROSTATIC AND PLASMATIC): A MICE IN VIVO STUDY.

Here, we hypothesized that modulating the plasmatic levels of 5-HT through a tryptophan-rich diet we could inhibit prostatic growth. METHODS: C57BL6 adult male mice were divided in 2 groups, Group 1: fed with a normal diet and Group 2: fed with, for a 3-month period. After the sacrifice of the mice, the prostate was dissected and weighted. By ELISA, prostatic 5-HT concentration was determined and by Western Blot, AR expression was evaluated in both groups. RESULTS: We observed that mice fed with a tryptophan-rich diet for 3 months present a significant reduction in the prostatic weight comparatively to mice fed with normal diet (fig1). Intra-prostatic 5-HT concentration was significantly increased in mice fed with a tryptophanrich diet (fig2). Furthermore, we demonstrated that the expression of AR in prostatic tissue from mice who underwent tryptophan supplementation was inferior to the AR expression in the normal diet group (fig3). CONCLUSIONS: Modulating diet through tryptophan enrichment, with the consequent increase in prostatic serotonin, decreases prostate size and down-regulates AR. These results suggests that a tryptophan rich diet could be potential used to prevent or treat BPH.

Abscess originating from osteomyelitis as a cause of lower urinary tract symptoms (LUTS) and acute urinary retention

Lower urinary tract symptoms (LUTS) are a common complaint in the general population with great impact on the quality of life. Besides the classical pathologies, there are less common causes that must be considered in the treatment approach for patients with LUTS. We present the case of a 30-year-old patient with multiple emergency department episodes with dysuria, urinary frequency, suprapubic pain and an episode of acute urinary retention. The blood and urine tests only revealed increased systemic inflammatory parameters. The ultrasound examination showed thickening of the bladder wall, and the CT scan revealed a retropubic abscess originating from a pubic symphysis osteomyelitis. A percutaneous drainage was performed and, after empirical antibiotic therapy, there was complete resolution of the clinical picture.

V5-10 EXTRAPERITEONAL SIMPLE PROSTATECTOMY: A SURGERY FOR BEGINNERS?

RESULTS: After initial inspection of the bladder demonstrated asymptomatic ureteroceles, an incision was made at the bladder neck and carried to the depth of the surgical capsule distally to the verumontanum. The lateral dissection expresses purulence almost immediately and a large abscess pocket is encountered during the anterior dissection. The remainder of the enucleation is performed without complication. The patient was spontaneously voiding by POD 2 and discharged with IV antibiotics for 6 weeks to treat his osteomyelitis. CONCLUSIONS: Holmium laser enucleation of a prostatic abscess can be performed safely and effectively to both maximally reduce the abscess cavity and risk of excessive thermal injury when treating an apically located abscess.