Joaquim Ferreira

EFNS/MDS‐ES recommendations for the diagnosis of Parkinson's disease

A Task Force was convened by the EFNS/MDS‐ES Scientist Panel on Parkinsons disease (PD) and other movement disorders to systemically review relevant publications on the diagnosis of PD.

An overview of electromagnetic inductance tomography: Description of three different systems

This paper presents a general overview of electromagnetic inductance tomography (EMT). A general introduction is given together with a description of the theoretical background of the technique. Three examples of different EMT systems are discussed and images produced using several different image reconstruction techniques are presented. A discussion of the main features of the techniques is included and some potential applications are suggested.

The FTT-CAN protocol for flexibility in safety-critical systems

A new communication protocol for distributed embedded systems attempts to find a compromise between the often-opposing goals of system flexibility and safety.

Combining operational flexibility and dependability in FTT-CAN

The traditional approaches to the design of distributed safety-critical systems, due to fault-tolerance reasons, have mostly considered static cyclic table-based traffic scheduling. However, there is a growing demand for operational flexibility and integration, mainly to improve efficiency in the use of system resources, with the network playing a central role to support such properties. This calls for dynamic online traffic scheduling techniques so that dynamic communication requirements are adequately supported. Nevertheless, using dynamic traffic management mechanisms raises additional problems, in terms of fault-tolerance, related with the weaker knowledge of the future system state caused by the higher level of operational flexibility. Such problems have been recently addressed in the scope of using flexible time-triggered CAN (FTT-CAN) in safety-critical applications in order to benefit from the high operational flexibility of this protocol. This paper gathers and reviews the main mechanisms that were developed to provide dependability to the protocol, namely, master replication and fail-silence enforcement.

A genome-wide association study in multiple system atrophy

Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed. Results: We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p < 1 × 10−6, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA. Conclusions: We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps.

Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients

Depigmentation of the substantia nigra (SN) and locus coeruleus (LC) is a conspicuous pathological feature of Parkinsons disease (PD) and is related to the loss of neuromelanin, whose paramagnetic properties result in high signal on specific T1‐weighted magnetic resonance imaging (MRI). Recent studies have suggested that neuromelanin decrease in the SN and LC of PD patients may emerge as a possible diagnostic biomarker. The SN neuromelanin signal in de novo and early stage PD patients was studied to assess its diagnostic accuracy. This is the first study based on a semi‐automated MRI analysis of the neuromelanin signal in de novo PD patients.

Introduction to Intelligent Transportation Systems

Transportation systems are very important in modern life; therefore, massive research efforts has been devoted to this field of study in the recent past. Effective vehicular connectivity techniques can significantly enhance efficiency of travel, reduce traffic incidents and improve safety, alleviate the impact of congestion; devising the so-called Intelligent Transportation Systems (ITS) experience. This chapter aims to provide basic concepts and background that is useful for the understanding of this book. An overview of intelligent transportation systems and their applications is presented, followed by a brief discussion of vehicular communications. The chapter also overviews the concepts related to dependability on distributed real-time systems in the scope if ITS.

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial

Importance Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of-dose motor fluctuations associated with levodopa therapy in patients with Parkinson disease (PD). Current COMT inhibitors carry a high risk for toxic effects to hepatic cells or show moderate improvement. Opicapone was designed to be effective without the adverse effects. Objective To evaluate the efficacy and safety of 25- and 50-mg/d dosages of opicapone compared with placebo as adjunct to levodopa therapy in patients with PD experiencing end-of-dose motor fluctuations. Design This phase 3 international, multicenter outpatient study evaluated a 25- and a 50-mg/d dosage of opicapone in a randomized, double-blind, 14- to 15-week, placebo-controlled clinical trial, followed by a 1-year open-label phase during which all patients received active treatment with opicapone. Patients with PD who experienced signs of end-of-dose deterioration and had a mean total awake off-time (state of akinesia or decreased mobility) of at least 1.5 hours, not including morning akinesia, were enrolled. Data were collected from March 18, 2011, through June 25, 2013. Data from the evaluable population were analyzed from July 31, 2013, to July 31, 2014. Main Outcomes and Measures The primary efficacy outcome of the double-blind phase was the change from baseline in absolute off-time vs placebo based on patient diaries. The open-label phase focused on maintenance of treatment effect in off-time. Results A total of 427 patients (258 men [60.4%] and 169 women [39.6%]; mean [SD] age, 63.1 [8.8] years) were randomized to a 25-mg/d (n = 129) or a 50-mg/d (n = 154) dosage of opicapone or to placebo (n = 144). Of these, 376 patients completed the double-blind phase and entered the open-label phase, of whom 286 completed 1 year of open-label treatment. At the end of the double-blind phase, the least squares mean change (SE) in off-time was −64.5 (14.4) minutes for the placebo group, −101.7 (14.9) minutes for the 25-mg/d opicapone group, and −118.8 (13.8) minutes for the 50-mg/d opicapone group. The adjusted treatment difference vs placebo was significant for the 50-mg/d opicapone group (treatment effect, −54.3 [95% CI, −96.2 to −12.4] minutes; P = .008), but not for the 25-mg/d opicapone group (treatment effect, −37.2 [95% CI, −80.8 to 6.4] minutes; P = .11). The off-time reduction was sustained throughout the open-label phase (−126.3 minutes at 1-year open-label end point). The most common adverse events in the opicapone vs placebo groups were dyskinesia, constipation, and dry mouth. Fifty-one patients (11.9%) discontinued from the study during the double-blind phase. Conclusions and Relevance Treatment with a 50-mg once-daily dose of opicapone was associated with a significant reduction in mean daily off-time in levodopa-treated patients with PD and motor fluctuations, and this effect is maintained for at least 1 year. Opicapone was safe and well tolerated. Trial Registration clinicaltrials.gov Identifier: NCT01227655

Scientific rigor and the art of motorcycle maintenance

The reliability of scientific research is under scrutiny. A recently convened working group proposes cultural adjustments to incentivize better research practices.

Implementing a distributed sensing and actuation system: The CAMBADA robots case study

The use of distributed computing architectures has become commonplace in complex embedded systems with potential advantages, for example, in terms of scalability, dependability and maintainability. One particular area in which that trend can be witnessed is mobile autonomous robotics in which several sensors and actuators are interconnected by means of a control network. In this paper we address one case study concerning the CAMBADA robots that were developed at the University of Aveiro for the Robocup Middle Size League. These robots have a distributed architecture with two layers, a coordination layer responsible for the global behaviors and a distributed sensing and actuating layer that conveys internal state information and executes coordination commands. This paper focuses on the latter layer, which is based on the FTT-CAN protocol, following a network-centric approach that provides an efficient framework for the synchronization of all systems activities. We describe the computing and communication requirements, the robot architecture, the system design and implementation, and finally we provide experimental results that show advantages with respect to a non-synchronized distributed approach