Joerg Neymeyer

Native tissue repair for central compartment prolapse: a narrative review.

Central descent due to a level 1 defect is a main component in pelvic organ prolapse (POP) reconstructive surgery, whether for symptomatic apical prolapse or for the prolapse repair of other compartments. A recent growth in the rate of native tissue repair procedures for POP, following the US Food and Drug Administration (FDA) warnings regarding the safety and efficacy of synthetic meshes, requires a re-evaluation of these procedures. The safety, efficacy, and determination of the optimal surgical approach should be the center of attention. Functional outcome measures and patient-centered results have lately gained importance and received focus. A comprehensive literature review was performed to evaluate objective and subjective outcomes of apical prolapse native tissue repair, with a special focus on studies reporting impact on patients’ functional outcomes, quality of life, and satisfaction. We performed a MEDLINE search for articles in the English language by using the following key words: apical prolapse, sacrospinous ligament fixation, uterosacral ligament suspension, sacral colpopexy, McCall culdoplasty, iliococcygeus vaginal fixation, and functional outcomes. We reviewed references as well. Despite a prominent shortage of studies reporting standardized prospective outcomes for native tissue repair interventions, we noted a high rate of safety and efficacy, with a low complication rate for most procedures and low recurrence or re-treatment rates. The objective and subjective results of different procedures are reviewed. Functional outcomes of native tissue repair procedures have not been studied sufficiently, though existing data present those procedures as favorable and not categorically inferior to sacrocolpopexy. Apical compartment prolapse repair using native tissue is not a compromise. Functional outcomes of native tissue repair procedures are favorable, have a high rate of success, improve women’s quality of life (QoL), and result in high rates of patient satisfaction. This subject requires further long-term, standardized prospective studies following the International Continence Society/International Urogynecologists Association guidelines for surgical outcomes report, with the focus on patient-centered functional outcomes.

Complications, functional and quality of life outcomes following primary and secondary implantation of penile prosthesis at a tertiary referral center

The implantation of a penile prosthesis (PP) may be recommended in patients with severe erectile dysfunction (ED) who do not respond to conservative treatments. The aim of this study was to evaluate complications, as well as functional and quality of life outcomes following primary and secondary implantation of PP at a tertiary referral center. In this retrospective study, a total of 51 patients (41 patients with primary (PPP) and 10 with secondary PP (SPP)) were included. Patients and operative characteristics were recorded and complications were analyzed using the Clavien-Dindo classification. To evaluate satisfaction of patients and their partners, as well as PP long-term function, follow-up data were collected by using questionnaires (Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) and QLQC30). Fifty-one patients with a median age of 61 years (IQR 52–68) received PP implantation (44 AMS 700, 7 Coloplast Titan). Main causes of ED were after radical prostatectomy (27.5%), diabetes (21,6%), and other unknown reasons (43.1%). Median time of intervention was 94.5 min (IQR 80.8–110.3) with no significant difference between PPP and SPP. Only one patient undergoing PPP surgery had grade 3 complication. Follow-up data from a total of 43 patients (84.3%) with a median follow-up of 26 months (IQR 17–41 mo) was recorded. At the time of follow-up, 88.4% of the PPs were still functional (PPP n = 34 (94.4%), SPP n = 4 (57.1%), p = 0.024). Overall estimated mean PP survival was 63.0 mo ((95% CI) 56.2–70.8 mo) with no significant difference between PPP and SPP. Overall satisfaction (EDITS und QLQC30) was high in both groups with no significant difference. PP implantation shows to be a safe treatment option in the management of severe ED.

Long‐term functional outcomes following mesh‐augmented posterior vaginal prolapse repair

To assess long‐term patient‐centered functional outcomes following posterior vaginal wall repair using mesh implants.